Abstract
Nanotechnology has made an extensive headway in medicinal field over recent times with its application in specific targeting of diseases and drug delivery. It furnishes all the possible path for current medical issues by employing smaller, faster, lighter, and better performing materials. Different types of complex nanocarriers used in drug delivery system have evolved immensely emphasizing on minimum toxicity and higher efficiency. This current review focuses on various organic and inorganic nanoparticle-based methodologies for targeted drug delivery along with a brief note on the evolving magnetic nanoparticles and drug delivery based on stimuli-responsive and biodegradable polymeric nanoparticles. The implementation of nano-based delivery system for the treatment of tumor, coronary artery disease, Alzheimer’s disease, and diabetes mellitus has also been discussed in the paper. Additionally, a crisp insight on some recent trends in nanocarrier discoveries for safe and personalized drug delivery system, drug resistance overcome by nanotechnology, and some possible way outs from the appeared shortcomings have been provided. The aim of this study majorly focuses on the large-scale importance of nanomedicines in improving the therapeutic outcome of numerous drugs with special reference to few pre-eminent disease therapies articulated in detail through this review which has been accompanied by discussions on how nanotechnology has evaded the problems associated with traditional drug delivery system by altering basic properties of drugs. On reaching the epilogue, we have a better understanding of the promising opportunities that nanotechnology bestows upon medical science and drug delivery for more specific and less toxic therapeutics.
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Acknowledgements
Authors are thankful to the Department of Chemistry, Amity Institute of Applied Sciences, Amity University Uttar Pradesh, for providing opportunity in the form of non-teaching credit course for completion of this work. Authors are also thankful to Amity University for providing necessary library facility for compilation of information.
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Deepshikha Gupta (DG): conceptualization, methodology, resources, original draft preparation, review, editing and supervision. Ankita Thakuria (AT) and Bharti Kataria (BK): data collection, visualization, resources and writing. All authors have read and agreed to the current version of the manuscript.
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Thakuria, A., Kataria, B. & Gupta, D. Nanoparticle-based methodologies for targeted drug delivery—an insight. J Nanopart Res 23, 87 (2021). https://doi.org/10.1007/s11051-021-05190-9
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DOI: https://doi.org/10.1007/s11051-021-05190-9