[go: up one dir, main page]
Skip to main content
SpringerLink
Log in

Interactions between a skin penetration enhancer and the main components of human stratum corneum lipids

Isothermal titration calorimetry study

  • Published:
Journal of Thermal Analysis and Calorimetry Aims and scope Submit manuscript

Abstract

The study employed isothermal titration calorimetry (ITC) technique to investigate the interactions between a skin penetration enhancer, laurocapram, and three representatives of the human stratum corneum (SC) intercellular lipids, i.e., ceramide-3, cholesterol and behenic acid. Experiments were performed using a TAM2277 (Thermometric AB, Sweden) calorimeter. Results showed that, firstly, two laurocapram molecules were bound to one ceramide-3 molecule in propylene glycol solution. The binding was enthalpy-driven and system entropy decreased after binding. Secondly, the binding ratio between cholesterol and laurocapram molecule was one to one. It was mainly an entropy-driven process, suggesting the ordered cholesterol molecules in SC lamella were disturbed by the introduction of laurocapram. Hydrogen bonding might be the main force of the binding. The three different interaction modes showed that the chemical enhancers selectively interacted with the components of SC lipids so that the SC can still retain its barrier function.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. BW Barry (2004) Nat. Biotechnol 22 165 Occurrence Handle10.1038/nbt0204-165 Occurrence Handle1:CAS:528:DC%2BD2cXnvFejsw%3D%3D

    Article  CAS  Google Scholar 

  2. JA Bouwstra PL Honeywell-Nguyen GS Gooris et al. (2003) Prog. Lipid Res. 42 1 Occurrence Handle1:CAS:528:DC%2BD38XptFGku7k%3D

    CAS  Google Scholar 

  3. J Hadgraft (2001) Int. J. Pharm. 224 1 Occurrence Handle10.1016/S0378-5173(01)00731-1 Occurrence Handle1:CAS:528:DC%2BD3MXmtVarur8%3D

    Article  CAS  Google Scholar 

  4. JA Neelissen C Arth M Wolff et al. (2000) Acta Derm. Venereol. Suppl. 208 36 Occurrence Handle1:STN:280:DC%2BD3M%2Fjt1Oqsw%3D%3D

    CAS  Google Scholar 

  5. ME Johnson D Blankschtein R Langer (1997) J. Pharm. Sci. 86 1162 Occurrence Handle1:CAS:528:DyaK2sXlvVygsLs%3D

    CAS  Google Scholar 

  6. LA Goldsmith (1991) Physiology, biochemistry, and molecular biology of the skin Oxford University Press Oxford

    Google Scholar 

  7. PW Wertz DC Swartzendruber KC Madison et al. (1987) J. Invest. Dermatol. 89 419 Occurrence Handle10.1111/1523-1747.ep12471781 Occurrence Handle1:CAS:528:DyaL1cXjvVah

    Article  CAS  Google Scholar 

  8. DT Downing (1992) J. Lipid Res. 33 301 Occurrence Handle1:CAS:528:DyaK38XhvFWntLo%3D

    CAS  Google Scholar 

  9. JA Bouwstra GS Gooris FER Dubbelaar M Ponec (2001) J. Lipid Res. 42 1759 Occurrence Handle1:CAS:528:DC%2BD3MXovVOku7c%3D

    CAS  Google Scholar 

  10. ME Stewart DT Downing (1999) J. Lipid Res. 40 1434 Occurrence Handle1:CAS:528:DyaK1MXlt1Clsbg%3D

    CAS  Google Scholar 

  11. TJ McIntosh ME Stewart DT Downing (1996) Biochemistry 35 3649 Occurrence Handle1:CAS:528:DyaK28XhtlygtLY%3D

    CAS  Google Scholar 

  12. S Raudenkolb W Hubner W Rettig et al. (2003) Chem. Phys. Lipids 123 9 Occurrence Handle1:CAS:528:DC%2BD3sXhvFWqt7o%3D

    CAS  Google Scholar 

  13. S Raudenkolb S Wartewig RH Neubert (2003) Chem. Phys. Lipids 124 89 Occurrence Handle1:CAS:528:DC%2BD3sXks1WltLc%3D

    CAS  Google Scholar 

  14. CA Phillips BB Michniak (1995) J. Pharm. Sci. 84 1427 Occurrence Handle1:CAS:528:DyaK2MXptFGisLc%3D

    CAS  Google Scholar 

  15. GSK Pilgram AM Engelsma-van Pelt HK Koerten JA Bouwstra (2000) Pharm. Res. 17 796 Occurrence Handle10.1023/A:1007547906856 Occurrence Handle1:CAS:528:DC%2BD3cXmsFGqt7c%3D

    Article  CAS  Google Scholar 

  16. JE Harrison AC Watkinson DM Green et al. (1996) Pharm. Res. 13 542 Occurrence Handle10.1023/A:1016037803128 Occurrence Handle1:CAS:528:DyaK28Xit12rurk%3D

    Article  CAS  Google Scholar 

  17. I Wadso RN Goldberg (2001) Pure Appl. Chem. 73 1625 Occurrence Handle1:CAS:528:DC%2BD38XjslWrug%3D%3D

    CAS  Google Scholar 

  18. I Jelesarov HR Bosshard (1999) J. Mol. Recognit. 12 3 Occurrence Handle10.1002/(SICI)1099-1352(199901/02)12:1<3::AID-JMR441>3.0.CO;2-6 Occurrence Handle1:CAS:528:DyaK1MXit1CjsrY%3D

    Article  CAS  Google Scholar 

  19. R Karlsson K Lennart (1976) Chemica Scripta 9 54 Occurrence Handle1:CAS:528:DyaE28XhslSmsbc%3D

    CAS  Google Scholar 

  20. D Hallen (1993) Pure Appl. Chem. 65 1527 Occurrence Handle1:CAS:528:DyaK3sXkvVWhurc%3D

    CAS  Google Scholar 

  21. GL Flynn Y Shah S Prakongpan et al. (1979) J. Pharm. Sci. 68 1090 Occurrence Handle1:CAS:528:DyaE1MXlvFyrt7o%3D

    CAS  Google Scholar 

  22. BW Barry (2001) Eur. J. Pharm. Sci. 14 101 Occurrence Handle1:CAS:528:DC%2BD3MXlslGnsLY%3D

    CAS  Google Scholar 

  23. MR Prausnitz S Mitragotri R Langer (2004) Nat. Rev. Drug. Discov. 3 115 Occurrence Handle10.1038/nrd1304 Occurrence Handle1:CAS:528:DC%2BD2cXhtlartbg%3D

    Article  CAS  Google Scholar 

  24. H Aki E Koizumi Y Okamoto M Yamamoto (2001) J. Therm. Anal. Cal. 64 293 Occurrence Handle1:CAS:528:DC%2BD3MXktFyjtr4%3D

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacy, National University of Singapor, Singapore, Republic of Singapore, 117543, Science Drive 4

    Kang L, Ho P C & Chan S Y

Authors
  1. Kang L
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ho P C
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chan S Y
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chan S Y.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kang, L., Ho, P.C. & Chan, S.Y. Interactions between a skin penetration enhancer and the main components of human stratum corneum lipids. J Therm Anal Calorim 83, 27–30 (2006). https://doi.org/10.1007/s10973-005-7050-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10973-005-7050-8

Keywords

Search

Navigation