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A Novel Evaluation Framework for Medical LLMs: Combining Fuzzy Logic and MCDM for Medical Relation and Clinical Concept Extraction

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Abstract

Artificial intelligence (AI) has become a crucial element of modern technology, especially in the healthcare sector, which is apparent given the continuous development of large language models (LLMs), which are utilized in various domains, including medical beings. However, when it comes to using these LLMs for the medical domain, there’s a need for an evaluation platform to determine their suitability and drive future development efforts. Towards that end, this study aims to address this concern by developing a comprehensive Multi-Criteria Decision Making (MCDM) approach that is specifically designed to evaluate medical LLMs. The success of AI, particularly LLMs, in the healthcare domain, depends on their efficacy, safety, and ethical compliance. Therefore, it is essential to have a robust evaluation framework for their integration into medical contexts. This study proposes using the Fuzzy-Weighted Zero-InConsistency (FWZIC) method extended to p, q-quasirung orthopair fuzzy set (p, q-QROFS) for weighing evaluation criteria. This extension enables the handling of uncertainties inherent in medical decision-making processes. The approach accommodates the imprecise and multifaceted nature of real-world medical data and criteria by incorporating fuzzy logic principles. The MultiAtributive Ideal-Real Comparative Analysis (MAIRCA) method is employed for the assessment of medical LLMs utilized in the case study of this research. The results of this research revealed that “Medical Relation Extraction” criteria with its sub-levels had more importance with (0.504) than “Clinical Concept Extraction” with (0.495). For the LLMs evaluated, out of 6 alternatives, (\(A4\)) “GatorTron S 10B” had the 1st rank as compared to (\(A1\)) “GatorTron 90B” had the 6th rank. The implications of this study extend beyond academic discourse, directly impacting healthcare practices and patient outcomes. The proposed framework can help healthcare professionals make more informed decisions regarding the adoption and utilization of LLMs in medical settings.

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Data Availability

No datasets were generated or analysed during the current study.

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Acknowledgements

This work was supported by Tenaga Nasional Berhad (TNB) and UNITEN through the BOLD Refresh Postdoctoral Fellowships under the project code of J510050002-IC-6 BOLDREFRESH2025-Centre of Excellence.

Author information

Authors and Affiliations

  1. Institute of Informatics and Computing in Energy, Universiti Tenaga Nasional, Kajang, Malaysia

    A. H. Alamoodi & Salman Yussof

  2. Applied Science Research Center, Applied Science Private University, Amman, Jordan

    A. H. Alamoodi

  3. MEU Research Unit, Middle East University, Amman, Jordan

    A. H. Alamoodi

  4. Information Systems and Computer Science Department, Ahmed bin Mohammed Military College, Al-Shahaniya, Qatar

    Omar Zughoul

  5. Faculty of Computing and Meta-Technology (FKMT), Universiti Pendidikan Sultan Idris (UPSI), Perak, Malaysia

    Dianese David & Salem Garfan

  6. Széchenyi István University, Győr, Hungary

    Dragan Pamucar

  7. Department of Industrial Engineering & Management, Yuan Ze University, Taoyuan, 320315, Taiwan

    Dragan Pamucar

  8. Department of Mechanics and Mathematics, Western Caspian University, Baku, Azerbaijan

    Dragan Pamucar

  9. Australian Technical and Management College, Melbourne, Australia

    O. S. Albahri

  10. Computer Techniques Engineering Department, Mazaya University College, Nasiriyah, Iraq

    O. S. Albahri

  11. Technical College, Imam Ja’afar Al-Sadiq University, Baghdad, Iraq

    A. S. Albahri

  12. Iraqi Commission for Computers and Informatics (ICCI), Baghdad, Iraq

    A. S. Albahri

  13. Department of Computing, College of Computing and Informatics, Universiti Tenaga Nasional, Kajang, Malaysia

    Salman Yussof

  14. Department of Basic Sciences, Higher Technological Institute, Tenth of Ramadan City, Egypt

    Iman Mohamad Sharaf

Authors
  1. A. H. Alamoodi
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  2. Omar Zughoul
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  3. Dianese David
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  4. Salem Garfan
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  5. Dragan Pamucar
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  6. O. S. Albahri
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  7. A. S. Albahri
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  8. Salman Yussof
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  9. Iman Mohamad Sharaf
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Contributions

A.H. Alamoodi, Omar Zughoul, and Dianese David: Writing- Original draft preparation, Salem Garfan, and O.S. Albahri: Conceptualization, Methodology, Dragan Pamucar: Conceptualization, A.S. Albahri: Project Administration, Salman Yussof: Manuscript Revision, Iman Mohamad Sharaf: Writing—Review & Editing.

Corresponding author

Correspondence to A. H. Alamoodi.

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Alamoodi, A.H., Zughoul, O., David, D. et al. A Novel Evaluation Framework for Medical LLMs: Combining Fuzzy Logic and MCDM for Medical Relation and Clinical Concept Extraction. J Med Syst 48, 81 (2024). https://doi.org/10.1007/s10916-024-02090-y

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  • DOI: https://doi.org/10.1007/s10916-024-02090-y

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