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Recovery of rhythmic activity in a central pattern generator: analysis of the role of neuromodulator and activity-dependent mechanisms

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Abstract

The pyloric network of decapods crustaceans can undergo dramatic rhythmic activity changes. Under normal conditions the network generates low frequency rhythmic activity that depends obligatorily on the presence of neuromodulatory input from the central nervous system. When this input is removed (decentralization) the rhythmic activity ceases. In the continued absence of this input, periodic activity resumes after a few hours in the form of episodic bursting across the entire network that later turns into stable rhythmic activity that is nearly indistinguishable from control (recovery). It has been proposed that an activity-dependent modification of ionic conductance levels in the pyloric pacemaker neuron drives the process of recovery of activity. Previous modeling attempts have captured some aspects of the temporal changes observed experimentally, but key features could not be reproduced. Here we examined a model in which slow activity-dependent regulation of ionic conductances and slower neuromodulator-dependent regulation of intracellular Ca2+ concentration reproduce all the temporal features of this recovery. Key aspects of these two regulatory mechanisms are their independence and their different kinetics. We also examined the role of variability (noise) in the activity-dependent regulation pathway and observe that it can help to reduce unrealistic constraints that were otherwise required on the neuromodulator-dependent pathway. We conclude that small variations in intracellular Ca2+ concentration, a Ca2+ uptake regulation mechanism that is directly targeted by neuromodulator-activated signaling pathways, and variability in the Ca2+ concentration sensing signaling pathway can account for the observed changes in neuronal activity. Our conclusions are all amenable to experimental analysis.

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Acknowledgements

This research was supported by NIH grant MH64711 (JG).

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Author notes

  1. Yili Zhang

    Present address: Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX, 77030, USA

Authors and Affiliations

  1. Federated Department of Biological Sciences, New Jersey Institute of Technology & Rutgers University, Newark, NJ, USA

    Yili Zhang & Jorge Golowasch

  2. Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, NJ, USA

    Jorge Golowasch

  3. Federated Dept Biological Sciences, New Jersey Institute of Technology, University Heights, 435 Colton Hall, Newark, NJ, USA

    Jorge Golowasch

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  1. Yili Zhang
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Correspondence to Jorge Golowasch.

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Zhang, Y., Golowasch, J. Recovery of rhythmic activity in a central pattern generator: analysis of the role of neuromodulator and activity-dependent mechanisms. J Comput Neurosci 31, 685–699 (2011). https://doi.org/10.1007/s10827-011-0338-8

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  • DOI: https://doi.org/10.1007/s10827-011-0338-8

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