Abstract
Emerging evidence proposes a link between immune changes and pain, which is consistent with the inflammation theory and the increased incidence of neurodegenerative diseases. Flavonoids have long been used because of their anti-inflammatory potential activity and they are considered a promising alternative to alleviate neuropathic pain. The aim of this study was to investigate the antihyperalgesic effect of hesperidin and the presence of pro-inflammatory cytokines evaluated at peripheral and central levels in the chronic constriction injury as model of neuropathic pain in rats. Mechanical and thermal hyperalgesia were assessed in the aesthesiometer and plantar tests, respectively, as related to the presence of cytokines concentrations (TNF-α, IL-1β and IL-6) in sciatic nerve and segments of the spinal cord after 15 days chronic constriction injury model in rats receiving vehicle or hesperidin. Antihyperalgesic response of hesperidin (100 mg/kg) was associated to the presence of cytokines mainly at several sections of the spinal cord suggesting not only peripheral but also its involvement in central sensitization in the experimental neuropathic pain.
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Acknowledgements
We thank Profr. Marisa González for proof-reading this manuscript and Mr. J. S. Ledesma Luna for technical assistance. This study was partially funded with CONACYT No. 226454 y 256448. Azucena Ibeth Carballo Villalobos is also grateful for having received CONACYT-232903 fellowship.
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This study was partially funded with CONACYT No. 226454 and 256448. Azucena Ibeth Carballo Villalobos thank fellowship by CONACYT-232903.
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Carballo-Villalobos, A.I., González-Trujano, M.E., Alvarado-Vázquez, N. et al. Pro-inflammatory cytokines involvement in the hesperidin antihyperalgesic effects at peripheral and central levels in a neuropathic pain model. Inflammopharmacol 25, 265–269 (2017). https://doi.org/10.1007/s10787-017-0326-3
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DOI: https://doi.org/10.1007/s10787-017-0326-3