Abstract
Systemic lupus erythematosus (SLE) is a systemic inflammatory disease associated with genetic, environmental, hormonal, and immunological factors. One of these factors is vitamin D deficiency. Vitamin D plays many roles in the immune system. Several studies have suggested a potential role in the development of autoimmune diseases. SLE patients have low serum levels of vitamin D, which increase the possibility of an association between vitamin deficiency and disease onset and evolution. This review of the literature presents an analysis of the aspects related to the immunoregulatory effects of vitamin D and its importance for SLE, as well as the recommendations for vitamin D supplementation in these patients.
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Acknowledgments
This work was supported by grants from Fundo de Incentivo à Pesquisa e Eventos of the Hospital de Clínicas de Porto Alegre, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, and Conselho Nacional de Desenvolvimento Científico e Tecnológico.
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The authors have no disclosures to report relevant to this study.
Financial Support
Fund for Research and Event Promotion / Hospital de Clínicas de Porto Alegre (FIPE/HCPA).
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Schneider, L., dos Santos, A.S.P., Santos, M. et al. Vitamin D and systemic lupus erythematosus: state of the art. Clin Rheumatol 33, 1033–1038 (2014). https://doi.org/10.1007/s10067-014-2530-5
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DOI: https://doi.org/10.1007/s10067-014-2530-5