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Vitamin D and systemic lupus erythematosus: state of the art

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Abstract

Systemic lupus erythematosus (SLE) is a systemic inflammatory disease associated with genetic, environmental, hormonal, and immunological factors. One of these factors is vitamin D deficiency. Vitamin D plays many roles in the immune system. Several studies have suggested a potential role in the development of autoimmune diseases. SLE patients have low serum levels of vitamin D, which increase the possibility of an association between vitamin deficiency and disease onset and evolution. This review of the literature presents an analysis of the aspects related to the immunoregulatory effects of vitamin D and its importance for SLE, as well as the recommendations for vitamin D supplementation in these patients.

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References

  1. Holick MF (2004) Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 80:1678S–1688S

    CAS  PubMed  Google Scholar 

  2. vinh quốc Lu'o'ng K, Nguyễn LT (2013) The beneficial role of vitamin D in obesity: possible genetic and cell signaling mechanisms. Nutr J 12:89

    Article  PubMed  Google Scholar 

  3. Holick MF (2007) Vitamin D deficiency. N Engl J Med 357:266–281

    Article  CAS  PubMed  Google Scholar 

  4. Grant WB (2006) Epidemiology of disease risks in relation to vitamin D insufficiency. Prog Biophys Mol Biol 92:65–79

    Article  CAS  PubMed  Google Scholar 

  5. Holick MF, Chen TC (2008) Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 87:1080S–1086S

    CAS  PubMed  Google Scholar 

  6. Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A et al (2008) Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev 29:726–776

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Premaor MO, Furlanetto TW (2006) Vitamin D deficiency in adults: to better understand a new presentation of an old disease. Arq Bras Endocrinol Metab 50:25–37

    Article  Google Scholar 

  8. Holick MF (2008) Vitamin D: a D-Lightful health perspective. Nutr Rev 66:S182–S194

    Article  PubMed  Google Scholar 

  9. Takeyama K, Kitanaka S, Sato T, Kobori M, Yanagisawa J, Kato S (1997) 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis. Science 277:1827–1830

    Article  CAS  PubMed  Google Scholar 

  10. DeLuca HF (2004) Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 80:1689S–1696S

    CAS  PubMed  Google Scholar 

  11. Cross HS (2007) Extrarenal vitamin D hydroxylase expression and activity in normal and malignant cells: modification of expression by epigenetic mechanisms and dietary substances. Nutr Rev 65:S108–S112

    Article  PubMed  Google Scholar 

  12. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM et al (2011) The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 96:53–58

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. Cantorna MT, Mahon BD (2004) Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp Biol Med (Maywood) 229:1136–1142

    CAS  Google Scholar 

  14. McGrath JJ, Saha S, Burne TH, Eyles DW (2010) A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations. J Steroid Biochem Mol Biol 121:471–477

    Article  CAS  PubMed  Google Scholar 

  15. Hewison M (2012) An update on vitamin D and human immunity. Clin Endocrinol (Oxf) 76:315–325

    Article  CAS  Google Scholar 

  16. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA et al (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96:1911–1930

    Article  CAS  PubMed  Google Scholar 

  17. Vero V, Gasbarrini A (2012) The EFSA health claims 'learning experience'. Int J Food Sci Nutr 63(Suppl 1):14–16

    Article  PubMed  Google Scholar 

  18. Tripkovic L, Lambert H, Hart K, Smith CP, Bucca G et al (2012) Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr 95:1357–1364

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  19. Battault S, Whiting SJ, Peltier SL, Sadrin S, Gerber G, Maixent JM (2013) Vitamin D metabolism, functions and needs: from science to health claims. Eur J Nutr 52:429–441

    Article  CAS  PubMed  Google Scholar 

  20. Grad R (2004) Cod and the consumptive: a brief history of cod-liver oil in the treatment of pulmonary tuberculosis. Pharm Hist 46:106–120

    PubMed  Google Scholar 

  21. Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C (2010) Vitamin D: modulator of the immune system. Curr Opin Pharmacol 10:482–496

    Article  CAS  PubMed  Google Scholar 

  22. DeLuca HF (1992) New concepts of vitamin D functions. Ann N Y Acad Sci 669:59–68, discussion -9

    Article  CAS  PubMed  Google Scholar 

  23. Arnson Y, Amital H, Shoenfeld Y (2007) Vitamin D and autoimmunity: new aetiological and therapeutic considerations. Ann Rheum Dis 66:1137–1142

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  24. Adorini L, Penna G (2008) Control of autoimmune diseases by the vitamin D endocrine system. Nat Clin Pract Rheumatol 4:404–412

    Article  CAS  PubMed  Google Scholar 

  25. Alroy I, Towers TL, Freedman LP (1995) Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor. Mol Cell Biol 15:5789–5799

    CAS  PubMed Central  PubMed  Google Scholar 

  26. Lemire JM, Adams JS, Kermani-Arab V, Bakke AC, Sakai R, Jordan SC (1985) 1,25-Dihydroxyvitamin D3 suppresses human T helper/inducer lymphocyte activity in vitro. J Immunol 134:3032–3035

    CAS  PubMed  Google Scholar 

  27. Daniel C, Sartory NA, Zahn N, Radeke HH, Stein JM (2008) Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile. J Pharmacol Exp Ther 324:23–33

    Article  CAS  PubMed  Google Scholar 

  28. Lemire JM, Ince A, Takashima M (1992) 1,25-Dihydroxyvitamin D3 attenuates the expression of experimental murine lupus of MRL/l mice. Autoimmunity 12:143–148

    Article  CAS  PubMed  Google Scholar 

  29. Vaisberg MW, Kaneno R, Franco MF, Mendes NF (2000) Influence of cholecalciferol (vitamin D3) on the course of experimental systemic lupus erythematosus in F1 (NZBxW) mice. J Clin Lab Anal 14:91–96

    Article  CAS  PubMed  Google Scholar 

  30. Sakthiswary R, Raymond AA (2013) The clinical significance of vitamin D in systemic lupus erythematosus: a systematic review. PLoS One 8:e55275

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  31. Muñoz-Ortego J, Torrente-Segarra V, Prieto-Alhambra D, Salman-Monte TC, Carbonell-Abello J (2012) Prevalence and predictors of vitamin D deficiency in non-supplemented women with systemic lupus erythematosus in the Mediterranean region: a cohort study. Scand J Rheumatol 41:472–475

    Article  PubMed  Google Scholar 

  32. O'Regan S, Chesney RW, Hamstra A, Eisman JA, O'Gorman AM, Deluca HF (1979) Reduced serum 1,25-(OH)2 vitamin D3 levels in prednisone-treated adolescents with systemic lupus erythematosus. Acta Paediatr Scand 68:109–111

    Article  PubMed  Google Scholar 

  33. Monticielo OA, Teixeira TM, Chies JA, Brenol JC, Xavier RM (2012) Vitamin D and polymorphisms of VDR gene in patients with systemic lupus erythematosus. Clin Rheumatol 31:1411–1421

    Article  PubMed  Google Scholar 

  34. Kamen DL, Aranow C (2008) The link between vitamin D deficiency and systemic lupus erythematosus. Curr Rheumatol Rep 10:273–280

    Article  CAS  PubMed  Google Scholar 

  35. Costenbader KH, Feskanich D, Holmes M, Karlson EW, Benito-Garcia E (2008) Vitamin D intake and risks of systemic lupus erythematosus and rheumatoid arthritis in women. Ann Rheum Dis 67:530–535

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  36. Bonakdar ZS, Jahanshahifar L, Jahanshahifar F, Gholamrezaei A (2011) Vitamin D deficiency and its association with disease activity in new cases of systemic lupus erythematosus. Lupus 20:1155–1160

    Article  CAS  PubMed  Google Scholar 

  37. Hiraki LT, Munger KL, Costenbader KH, Karlson EW (2012) Dietary intake of vitamin D during adolescence and risk of adult-onset systemic lupus erythematosus and rheumatoid arthritis. Arthritis Care Res 64:1829–1836

    Article  CAS  Google Scholar 

  38. Ritterhouse LL, Crowe SR, Niewold TB, Kamen DL, Macwana SR et al (2011) Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus. Ann Rheum Dis 70:1569–1574

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  39. Ruiz-Irastorza G, Gordo S, Olivares N, Egurbide MV, Aguirre C (2010) Changes in vitamin D levels in patients with systemic lupus erythematosus: effects on fatigue, disease activity, and damage. Arthritis Care Res 62:1160–1165

    Article  CAS  Google Scholar 

  40. Petri M, Bello KJ, Fang H, Magder LS (2013) Vitamin D in systemic lupus erythematosus: modest association with disease activity and the urine protein-to-creatinine ratio. Arthritis Rheum 65:1865–1871

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  41. Abou-Raya A, Abou-Raya S, Helmii M (2013) The effect of vitamin D supplementation on inflammatory and hemostatic markers and disease activity in patients with systemic lupus erythematosus: a randomized placebo-controlled trial. J Rheumatol 40:265–272

    Article  CAS  PubMed  Google Scholar 

  42. Kiani AN, Fang H, Magder LS, Petri M (2013) Vitamin D deficiency does not predict progression of coronary artery calcium, carotid intima-media thickness or high-sensitivity C-reactive protein in systemic lupus erythematosus. Rheumatology (Oxford) 52:2071–2076

    Article  CAS  Google Scholar 

  43. Carolina MUoS (2007) Vitamin D therapy in patients with systemic lupus erythematosus (SLE). http://clinicaltrials.gov/ct2/show/study/NCT00418587?term=%22vitamin+D%22+AND+%22lupus%22&rank=3. Accessed July 2013

  44. (NIAID) NIoAaID (2008) Vitamin D3 in systemic lupus erythematosus. http://clinicaltrials.gov/ct2/show/NCT00710021?term=%22vitamin+D%22+AND+%22lupus%22&rank=2. Accessed July 2013

  45. Hollis BW (2004) Editorial: The determination of circulating 25-hydroxyvitamin D: no easy task. J Clin Endocrinol Metab 89:3149–3151

    Article  CAS  PubMed  Google Scholar 

  46. Pietras SM, Obayan BK, Cai MH, Holick MF (2009) Vitamin D2 treatment for vitamin D deficiency and insufficiency for up to 6 years. Arch Intern Med 169:1806–1808

    Article  PubMed  Google Scholar 

  47. Vieth R (2006) Critique of the considerations for establishing the tolerable upper intake level for vitamin D: critical need for revision upwards. J Nutr 136:1117–1122

    CAS  PubMed  Google Scholar 

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Acknowledgments

This work was supported by grants from Fundo de Incentivo à Pesquisa e Eventos of the Hospital de Clínicas de Porto Alegre, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, and Conselho Nacional de Desenvolvimento Científico e Tecnológico.

Conflict of interest

The authors have no disclosures to report relevant to this study.

Financial Support

Fund for Research and Event Promotion / Hospital de Clínicas de Porto Alegre (FIPE/HCPA).

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Authors and Affiliations

  1. Division of Rheumatology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, 645, Porto Alegre, 90035-003, Brazil

    Laiana Schneider, Amanda Senna Pereira dos Santos, Marcele Santos, Rafael Mendonça da Silva Chakr & Odirlei Andre Monticielo

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  1. Laiana Schneider
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  2. Amanda Senna Pereira dos Santos
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  3. Marcele Santos
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  4. Rafael Mendonça da Silva Chakr
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Correspondence to Odirlei Andre Monticielo.

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Schneider, L., dos Santos, A.S.P., Santos, M. et al. Vitamin D and systemic lupus erythematosus: state of the art. Clin Rheumatol 33, 1033–1038 (2014). https://doi.org/10.1007/s10067-014-2530-5

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  • DOI: https://doi.org/10.1007/s10067-014-2530-5

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