Abstract
Normal vision overrides perturbed vestibular information for the optimization of performance during goal directed locomotion, suggesting down-regulation of vestibular gain. However, it is not known if the responses to vestibular perturbation are accentuated when vision is impaired. Furthermore, both visual and vestibular systems deteriorate with age. It is not clear, however, how age-related decline in these sensory systems influences visual–vestibular interaction. Therefore, the dual purpose of the present study was to investigate the effects of aging and blurring vision, that simulated the consequences of cataracts, on visual–vestibular interaction. Young and healthy elderly walked to a target located straight ahead with either normal or blurring vision. On randomly selected trials vestibular system perturbation was achieved by applying transmastoidal galvanic vestibular stimulation (GVS). Two different galvanic stimulation intensities were used to provide insight into scaling effect of vestibular perturbation on locomotor performance and how age and vision influences this scaling effect. Maximum path deviation, frontal trunk tilt and postural coordination in the mediolateral direction were evaluated. The magnitude of the path deviation and the trunk tilt response were scaled to the magnitude of the vestibular perturbation in older adults independent of the visual condition. Older participants demonstrated increased coupling of the head and trunk segments irrespective of visual and vestibular perturbations. The results suggest that when visual information was available, the vestibular input reweighting was less effective in older individuals, as shown by the scaled responses to the GVS intensities and the inability to converge efficiently towards the target.
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References
Ali AS, Rowen KA, Iles JF (2002) Vestibular actions on back and lower limb muscles during postural tasks. J Physiol 546:615–624
Assaiante C (1998) Development of locomotor balance control in healthy children. Neurosci Biobehav Rev 22(4):527–532
Bent LR, McFadyen BJ, Merkley VF, Kennedy PM, Inglis JT (2000) Magnitude effects of galvanic vestibular stimulation on the trajectory of human gait. Neurosci Lett 279:157–160
Bent LR, McFayden BJ, Inglis JT (2002) Visual–vestibular interactions in postural control during the execution of a dynamic task. Exp Brain Res 14:490–500
Bent LR, Inglis JT, McFadyen BJ (2004) When is vestibular information important during walking? J Neurophysiol 92(3):1269–1275
Bergstrom B (1973) Morphology of the vestibular nerve. Analysis of the calibers of the myelinated vestibular nerve fibers in man at various ages. Acta Otolaryngol 76(5):331–338
Cohen HS (2000) Vestibular disorders and impaired path integration along a linear trajectory. J Vestib Res 10(1):7–15
Day BL, Cole J (2002) Vestibular-evoked postural responses in the absence of somatosensory information. Brain 125:2081–2088
Day BL, Guerraz M, Cole J (2002) Sensory interactions for human balance control revealed by galvanic vestibular stimulation. Adv Exp Med Biol 508:129–137
Deshpande N, Patla AE (2005a) Postural responses and spatial orientation to neck proprioceptive and vestibular inputs during locomotion in young and older adults. Exp Brain Res 167(3):468–474
Deshpande N, Patla AE (2005b) Dynamic visual–vestibular integration during goal directed human locomotion. Exp Brain Res 166(2):237–247
Elliott DB, Sanderson K, Conkey A (1990) The reliability of the Pelli–Robson contrast sensitivity chart. Ophthalmic Physiol Opt 10(1):21–24
Fitzpatrick RC, Day BL (2004) Probing the human vestibular system with galvanic stimulation. J Appl Physiol 96(6):2301–2316
Fitzpatrick RC, Wardman DL, Taylor JL (1999) Effects of galvanic vestibular stimulation during human walking. J Physiol 517:931–939
Glasauer S, Amorim MA, Vitte E, Berthoz A (1994) Goal-directed linear locomotion in normal and labyrinthine-defective subjects. Exp Brain Res 98(2):323–325
Glasauer S, Amorim MA, Viaud-Delmon I, Berthoz A (2002) Differential effects of labyrinthine dysfunction on distance and direction during blindfolded walking of a triangular path. Exp Brain Res 145(4):489–497
Goldberg JM, Smith CE, Fernandez C (1984) Relation between discharge regularity and response to externally applied galvanic currents in vestibular nerve afferents of the squirrel monkey. J Neurophysiol 51:1236–1256
Harris JM, Bonas W (2002) Optic flow and scene structure do not always contribute to the control of human walking. Vision Res 42(13):1619–1626
Hay L, Bard C, Fleury M, Teasdale N (1996) Availability of visual and proprioceptive afferent messages and postural control in elderly adults. Exp Brain Res 108(1):129–139
Heasley K, Buckley JG, Scally A, Twigg P, Elliott DB (2004) Stepping up to a new level: effects of blurring vision in the elderly. Invest Ophthalmol Vis Sci 45(7):2122–2128
Horak FB, Hlavacka F (2001) Somatosensory loss increases vestibulospinal sensitivity. J Neurophysiol 86(2):575–585
Horak FB, Nashner LM, Diener HC (1990) Postural strategies associated with somatosensory and vestibular loss. Exp Brain Res 82(1):167–177
Huxham FE, Goldie PA, Patla AE (2001) Theoretical considerations in balance assessment. Aust J Physiother 47:89–100
Jahn K, Strupp M, Schneider E, Dieterich M, Brandt T (2000) Differential effects of vestibular stimulation on walking and running. Neuroreport 11(8):1745–1748
Jahn K, Naessl A, Schneider E, Strupp M, Brandt T, Dieterich M (2003) Inverse U-shaped curve for age dependency of torsional eye movement responses to galvanic vestibular stimulation. Brain 126(7):1579–1589
Kennedy PM, Carlsen AN, Inglis JT, Chow R, Franks IM, Chua R (2003) Relative contributions of visual and vestibular information on the trajectory of human gait. Exp Brain Res 153(1):113–117
Keppel G (1991) Design and analysis: a researcher’s handbook. 3rd edn Prentice Hall Inc, New Jersey, pp 62–91
Lopez I, Honrubia V, Baloh RW (1997) Aging and the human vestibular nucleus. J Vestib Res 7(1):77–85
Maki BE, McIlroy WE (1996) Postural control in the older adult. Clin Geriatr Med 12(4):635–658
Mulavara AP, Bloomberg JJ (2002–2003) Identifying head–trunk and lower limb contributions to gaze stabilization during locomotion. J Vestib Res 12(5–6):255–269
Owings TM, Grabiner MD (2004) Step width variability, but not step length variability or step time variability, discriminates gait of healthy young and older adults during treadmill locomotion. J Biomech 37(6):935–938
Patla AE (2004) Adaptive human locomotion: influence of neural, biological and mechanical factors on control mechanism. In: Bronstein AM, Brandt T, Woollacott MH, Nutt JG (eds) Clinical disorders of balance, posture and gait. Arnold Publishers, London, UK pp 20–38
Prokop T, Schubert M, Berger W (1997) Visual influence on human locomotion. Modulation to changes in optic flow. Exp Brain Res 114(1):63–70
Rossignol S (1996) Visuomotor regulation of locomotion. Can J Physiol Pharmacol 74(4):418–425
Warren WH Jr, Kay BA, Zosh WD, Duchon AP, Sahuc S (2001) Optic flow is used to control human walking. Nat Neurosci 4(2):213–216
Welgampola MS, Colebatch JG (2001) Vestibulospinal reflexes: quantitative effects of sensory feedback and postural task. Exp Brain Res 139(3):345–353
Welgampola MS, Colebatch JG (2002) Selective effects of ageing on vestibular-dependent lower limb responses following galvanic stimulation. Clin Neurophysiol 113(4):528–534
Acknowledgments
This work was supported by NSERC, Canada and the Ontario Neurotrauma Foundation, Canada. We thank Sebastian Tomescu and Alison Novak for their help in data collection.
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Deshpande, N., Patla, A.E. Visual–vestibular interaction during goal directed locomotion: effects of aging and blurring vision. Exp Brain Res 176, 43–53 (2007). https://doi.org/10.1007/s00221-006-0593-5
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DOI: https://doi.org/10.1007/s00221-006-0593-5