Abstract
In this paper, a biological sensing model based on graphene oxide is proposed. A YES gate and a AND gate are constructed by using the ability of graphene oxide to adsorb single strand and quench fluorescence. The biosensor we designed can be used not only as a logical element, but also to detect a specific target DNA. Then, taking YES gate as an example, orthogonal experiments, condition optimization and target selective detection are carried out to demonstrate the practical significance of the sensing model designed. In subsequent experiments, we will design more complex logic components on this basis and try to apply them to practice.
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References
Wan, F., Dong, C., Yang, J., Dong, Y., et al.: The development and application of DNA computing technology. Bull. Chin. Acad. Sci. 1–7 (2014)
Li, C.H., Xiao, X., Tao, J., et al.: A graphene oxide-based strand displacement amplification platform for ricin detection using aptamer as recognition element. Biosens. Bioelectron. 91, 149–154 (2017)
Mao, Y., Chen, Y., Li, S., et al.: A graphene-based biosensing platform based on regulated release of an aptameric DNA biosensor. Sensors 15(11), 28244–28256 (2015)
Wang, L., Tian, J., Huang, Y., et al.: Homogenous fluorescence polarization assay for the DNA of HIV A T7 by exploiting exonuclease-assisted quadratic recycling amplification and the strong interaction between graphene oxide and ssDNA. Microchim. Acta 183(7), 2147–2153 (2016)
Luo, F., Xi, Q., Jiang, J.H., et al.: Graphene oxide based DNA nanoswitches as a programmable pH-responsive biosensor. Anal. Methods 8(38), 6982–6985 (2016)
Zhou, C., Liu, D., Wu, C., et al.: Integration of DNA and graphene oxide for the construction of various advanced logic circuits. Nanoscale 8(40), 17524–17531 (2016)
Ye, Y.D., Xia, L., Xu, D.D., et al.: DNA-stabilized silver nanoclusters and carbon nanoparticles oxide: a sensitive platform for label-free fluorescence turn-on detection of HIV-DNA sequences. Biosens. Bioelectron. 85, 837–843 (2016)
Chen, C., Li, N., Lan, J., et al.: A label-free colorimetric platform for DNA via target-catalyzed hairpin assembly and the peroxidase-like catalytic of graphene/Au-NPs hybrids. Anal. Chim. Acta 902, 154–159 (2016)
Zhu, J., Zhang, L., Dong, S., et al.: Four-way junction-driven DNA strand displacement and its application in building majority logic circuit. ACS Nano 7(11), 10211–10217 (2013)
Chen, L., Ji, X., He, Z.: Application of new fluorescence technology in virus detection. Chem. Sens. 32(4), 1–8 (2012)
Wu, C., Xu, F., et al.: Application of fluorescence labeling technology in biological and medical research. J. Chongqing Univ. Technol. 28(5), 55–62 (2014)
Xiong, Y., Wei, M., Wei, W., et al.: Detection of DNA damage based on metal-mediated molecular beacon and DNA strands displacement reaction. Spectrochim. Acta A Mol. Biomol. Spectrosc. 118(2), 806–810 (2014)
Zhang, L., Bluhm, A.M., Chen, K.J., et al.: Performance of nano-assembly logic gates with a DNA multi-hairpin motif. Nanoscale 9(4), 1709–1720 (2017)
Li, X., Guo, J., Zhai, Q., et al.: Ultrasensitive electrochemical biosensor for specific detection of DNA based on molecular beacon mediated circular strand displacement polymerization and hyperbranched rolling circle amplification. Anal. Chim. Acta 934, 52–58 (2016)
Adinolfi, B., Pellegrino, M., Giannetti, A., et al.: Molecular beacon-decorated polymethyl-methacrylate core-shell fluorescent nanoparticles for the detection of survivin mRNA in human cancer cells. Biosens. Bioelectron. 88, 15–24 (2016)
Desilva, A.P., Mcclenaghan, N.D.: Molecular-scale logic gates. Cheminform 10(3), 574–586 (2004)
Reif, J.H.: Successes and challenges. Science 296(5567), 478–479 (2002)
Patel, P.D.: (Bio) sensors for measurement of analytes implicated in food safety: a review. Trends Anal. Chem. 21(2), 96–115 (2002)
Bagni, G., Osella, D., Sturchio, E., et al.: Deoxyribonucleic acid (DNA) biosensors for environmental risk assessment and drug studies. Anal. Chim. Acta 573–574(1), 81 (2006)
Wang, J.: Electrochemical biosensors: towards point-of-care cancer diagnostics. Biosens. Bioelectron. 21(10), 1887–1892 (2006)
Bond, J.W.: Value of DNA evidence in detecting crime. J. Forensic Sci. 52(1), 128–136 (2007)
Cheng, N., Zhu, P., Xu, Y., et al.: High-sensitivity assay for Hg (II) and Ag (I) ion detection: a new class of droplet digital PCR logic gates for an intelligent DNA calculator. Biosens. Bioelectron. 84, 1–6 (2016)
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Wang, L., Zhang, Y., Wei, Y., Dong, Y. (2018). Multifunctional Biosensor Logic Gates Based on Graphene Oxide. In: Qiao, J., et al. Bio-inspired Computing: Theories and Applications. BIC-TA 2018. Communications in Computer and Information Science, vol 951. Springer, Singapore. https://doi.org/10.1007/978-981-13-2826-8_41
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DOI: https://doi.org/10.1007/978-981-13-2826-8_41
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