Abstract
To screen large populations for colorectal cancer, it may be necessary to reduce the radiation dose of computed tomographic colonography (CTC) examinations. We compared the accuracy of computer-aided detection (CAD) in standard-dose (SD) CTC with that in ultra-low-dose (ULD) CTC. We also assessed the effect of linear and nonlinear denoising methods on CAD performance in ULD CTC. The CAD system was trained to detect polyps with 43 SD CTC studies. It was tested with 24 clinical studies, where the supine series were acquired with SD CTC and the prone series were acquired with ULD CTC. The polyp detection accuracy of CAD was significantly lower in ULD CTC than in SD CTC. Linear denoising of ULD CTC images improved the detection accuracy for large polyps, but it reduced sensitivity for small polyps. However, with nonlinear denoising, the detection accuracy of CAD in ULD CTC was not significantly different from that in SD CTC.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Brenner, D., Georgsson, M.: Mass screening with CT colonography: should the radiation exposure be of concern? Gastroenterology 129, 328–337 (2005)
Chakraborty, D., Berbaum, K.: Observer studies involving detection and localization: modeling, analysis, and validation. Med. Phys. 31, 2313–2330 (2004)
Fisichella, V., Båth, M., Allansdotter, J., Jäderling, F., Bergsten, T., Persson, U., Mellingen, K., Hellström, M.: Evaluation of image quality and lesion perception by human readers on 3D CT colonography: comparison of standard and low radiation dose. Eur. Radiol. 20, 630–639 (2010)
Berrington de González, A., Kim, K., Landsdorp-Vogelaar, I., Rutter, C., et al.: Radiation-related cancer risks from CT colonography screening: a risk-benefit analysis. Am. J. Roentgenol. 196, 816–823 (2011)
Johnson, C., Chen, M.H., Toleday, A., Heiken, J., Dachman, A., Kuo, M., et al.: Accuracy of CT colonography for detection of large adenomas and cancers. N. Engl. J. Med. 359, 1207–1217 (2008)
Johnson, C., Dachman, A.: CT colonography: the next colon screening examination? Radiology 216, 331–341 (2000)
Kalra, M., Woisetschläger, M., Dahlström, N., Singh, S., Linblom, M., et al.: Radiation dose reduction with sinogram affirmed iterative reconstruction technique for abdominal computed tomography. J. Comput. Assist. Tomogr. 36, 339–346 (2012)
Kim, D., Pickhardt, P., Taylor, A., Leung, W., Winter, T., Hinshaw, J., Gopal, D., Reichelderfer, M., Hsu, R., Pfau, P.: CT colonography versus colonoscopy for the detection of advanced neoplasia. N. Engl. J. Med. 357, 1403–1412 (2007)
Kim, S., Lee, J., Shin, C., Kim, H., Lee, J., et al.: Effects of spatial resolution and tube current on computer-aided detection of polyps on CT colonographic images: phantom study. Radiology 248, 492–503 (2008)
Kiss, G., Drisis, S., Bielen, D., Maes, F., Van Cleynenbreugel, J., et al.: Computer-aided detection of colonic polyps using low-dose CT acquisitions. Acad. Radiol. 13, 1062–1071 (2006)
Laghi, A., Iafrate, F., Rengo, M., Hassan, C.: Colorectal cancer screening: the role of CT colonogrpahy. World J. Gastroenterol. 16, 3987–3994 (2010)
Näppi, J., Frimmel, H., Dachman, A., Yoshida, H.: A new high-performance CAD scheme for the detection of polyps in CT colonography. In: Fitzpatrick, J., Sonka, M. (eds.) SPIE Medical Imaging 2004, vol. 5370, pp. 839–848 (2004)
Näppi, J., Yoshida, H.: Automated detection of polyps in CT colonography: evaluation of volumetric features for reduction of false positives. Acad. Radiol. 9, 386–397 (2002)
Näppi, J., Yoshida, H.: Fully automated three-dimensional detection of polyps in fecal-tagging CT colonography. Acad. Radiol. 25, 287–300 (2007)
Perona, P., Malik, J.: Scale-space and edge detection using anisotropic diffusion. IEEE T. Pattern Anal. 12, 629–639 (1990)
Pickhardt, P., Choi, J., Hwang, I., Butler, J., Puckett, M., Hildebrandt, H., Wong, R., Nugent, P., Mysliwiec, P., Schindler, W.: Computed tomographic virtual colonoscopy to screen for colorectal neoplasia in asymptomatic adults. N. Engl. J. Med. 349, 2191–2200 (2003)
Schoonenberg, G.A.F., Vries, A.H., de Grigorescu, S.E., Peters, J., Vilanova, A., Truyen, R., Stoker, J., Gerritsen, F.A.: Effects of filtering on colorectal polyp detection in ultra low dose CT. In: Manduca, A., Amini, A. (eds.) SPIE Medical Imaging: Physiology, Function, and Structure from Medical Images, vol. 6143, pp. 18–1–18–10. SPIE, San Diego (2006)
Thorne, M.: Background radiation: natural and man-made. Radiol. Prot. 23, 29–42 (2003)
Yoshida, H., Näppi, J.: Three-dimensional computer-aided diagnosis scheme for detection of colonic polyps. IEEE Trans. Med. Imaging 20, 1261–1274 (2001)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Näppi, J.J., Imuta, M., Yamashita, Y., Yoshida, H. (2012). Computer-Aided Detection for Ultra-Low-Dose CT Colonography. In: Yoshida, H., Hawkes, D., Vannier, M.W. (eds) Abdominal Imaging. Computational and Clinical Applications. ABD-MICCAI 2012. Lecture Notes in Computer Science, vol 7601. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-33612-6_5
Download citation
DOI: https://doi.org/10.1007/978-3-642-33612-6_5
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-33611-9
Online ISBN: 978-3-642-33612-6
eBook Packages: Computer ScienceComputer Science (R0)