Abstract
Even though different computer-aided detection (CAD) systems for computed tomographic colonography (CTC) have similar overall detection accuracies, they are known to detect different types of lesions and false positives. We implemented an ensemble CAD scheme for merging the detection results of different CAD systems in CTC. After normalizing of the lesion-likelihood data between different systems, a Bayesian classifier was used for determining the final detections. For evaluation, we collected 218 abnormal patients with 263 lesions ≥6 mm. The detection accuracies of three CAD systems were compared with that of their ensemble CAD scheme by use of independent training and testing. The preliminary results indicate that the ensemble CAD scheme can yield a higher overall detection accuracy than can individual CAD systems. In particular, the ensemble scheme was able to detect flat lesions at high sensitivity without compromising a high polyp detection accuracy.
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References
Winawer, S.J., Fletcher, R.H., Miller, L., et al.: Colorectal Cancer Screening: Clinical Guidelines and Rationale. Gastroenterology 112, 594–642 (1997)
Levin, B., Lieberman, D.A., McFarland, B., et al.: Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: a Joint Guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer and the American College of Radiology. CA Cancer J. Clin. 58, 130–160 (2008)
Johnson, C.D., Chen, M.H., Toledano, A.Y., et al.: Accuracy of CT Colonography for Detection of Large Adenomas and Cancers. N. Engl. J. Med. 359, 1207–1217 (2008)
Pickhardt, P.J.: Differential Diagnosis of Polypoid Lesions seen at CT Colonography (Virtual Colonoscopy). Radiographics 24, 1535–1556 (2004)
Dachman, A.H., Obuschowski, N.A., Hoffmeister, J.W., et al.: Effect of Computer-Aided Detection for CT Colonography in a Multireader, Multicase Trial. Radiology 256, 827–835 (2010)
Lawrence, E.M., Pickhardt, P.J., Kim, D.H., Robbins, J.B.: Colorectal Polyps: Stand-Alone Performance of Computer-Aided Detection in a Large Asymptomatic Screening Population. Radiology 256, 791–798 (2010)
Yoshida, H., Näppi, J.: CAD in CT Colonography without and with Oral Contrast Agents: Progress and Challenges. Comput. Med. Imaging Graph 31, 267–284 (2007)
Hein, P.A., Krug, L.D., Romano, V.C., Kandel, S., Hamm, B., Rogalla, P.: Computer-Aided Detection in Computed Tomography Colonography with Full Fecal Tagging: Comparison of Standalone Performance of 3 Automated Polyp Detection Systems. Can Assoc. Radiol. J. 61, 102–108 (2010)
Park, H.S., Kim, S.H., Kim, J.H., et al.: Computer-Aided Polyp Detection on CT Colonography: Comparison of Three Systems in a High-Risk Human Population. Eur. J. Radiol. 75, 147–157 (2010)
Kuncheva, L.: Combining Pattern Classifiers: Methods and Algorithms. Wiley Interscience (2004)
Niemeijer, M., Loog, M., Abràmoff, M.D., Viergever, M.A., Prokop, M., van Ginneken, B.: On Combining Computer-Aided Detection Systems. IEEE Trans. Med. Imaging 30, 215–223 (2011)
van Ginneken, B., Armato III, S.G., de Hoop, B., et al.: Comparing and Combining Algorithms for Computer-Aided Detection of Pulmonary Nodules in Computed Tomography Scans: The ANODE09 Study. Med. Image Anal. 14, 707–722 (2010)
Näppi, J., Yoshida, H.: Fully Automated Three-Dimensional Detection of Polyps in Fecal-Tagging CT Colonography. Acad. Radiol. 14, 287–300 (2007)
Yoshida, H., Näppi, J.: Three-Dimensional Computer-Aided Diagnosis Scheme for Detection of Colonic Polyps. IEEE Trans. Med. Imaging 20, 1261–1274 (2001)
Näppi, J., Yoshida, H.: Feature-Guided Analysis for Reduction of False Positives in CAD of Polyps for Computed Tomographic Colonography. Med. Phys. 30, 1592–1601 (2003)
Näppi, J., Yoshida, H.: Automated Detection of Polyps with CT Colonography: Evaluation of Volumetric Features for Reduction of False-Positive Findings. Acad. Radiol. 9, 386–397 (2002)
Kupinski, M.A., Edwards, D.C., Giger, M.L., Metz, C.E.: Ideal Observer Approximation using Bayesian Classification Neural Networks. IEEE Trans. Med. Imaging 20, 886–899 (2001)
Breiman, L.: Random Forests. Machine Learning 45, 5–32 (2001)
Ambroise, C., McLachlan, J.H.: Selection Bias in Gene Extraction on the Basis of Microarray Gene-Expression Data. PNAS 99, 6562–6566 (2002)
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Näppi, J.J., Regge, D., Yoshida, H. (2012). Ensemble Detection of Colorectal Lesions for CT Colonography. In: Yoshida, H., Sakas, G., Linguraru, M.G. (eds) Abdominal Imaging. Computational and Clinical Applications. ABD-MICCAI 2011. Lecture Notes in Computer Science, vol 7029. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28557-8_8
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DOI: https://doi.org/10.1007/978-3-642-28557-8_8
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