Abstract
It is generally accepted that interorganellar contacts are central to the control of cellular physiology. Virtually, any intracellular organelle can come into proximity with each other and, by establishing physical protein-mediated contacts within a selected fraction of the membrane surface, novel specific functions are acquired. Endoplasmic reticulum (ER) contacts with mitochondria are among the best studied and have a major role in Ca2+ and lipid transfer, signaling, and membrane dynamics.
Their functional (and structural) diversity, their dynamic nature as well as the growing number of new players involved in the tethering concurred to make their monitoring difficult especially in living cells. This review focuses on the most established examples of tethers/modulators of the ER-mitochondria interface and on the roles of these contacts in health and disease by specifically dissecting how Ca2+ transfer occurs and how mishandling eventually leads to disease. Additional functions of the ER-mitochondria interface and an overview of the currently available methods to measure/quantify the ER-mitochondria interface will also be discussed.
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Acknowledgements
This work was supported by grants from the UniversitĂ degli Studi di Padova (Progetto di Ateneo 2015 n. CPDA 153402 to MB, Progetto Giovani 2012 n.GRIC128SP0 to TC and Progetto di Ateneo 2016 n. CALI_SID16_01 to TC) and from the Ministry of University and Research (Bando SIR 2014 n. RBSI14C65Z to TC).
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Vallese, F., Barazzuol, L., Maso, L., Brini, M., Calì, T. (2020). ER-Mitochondria Calcium Transfer, Organelle Contacts and Neurodegenerative Diseases. In: Islam, M. (eds) Calcium Signaling. Advances in Experimental Medicine and Biology, vol 1131. Springer, Cham. https://doi.org/10.1007/978-3-030-12457-1_29
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