Abstract
A major problem with non-rigid image registration techniques in many applications is their tendency to reduce the volume of contrast-enhancing structures [10]. Contrast enhancement is an intensity inconsistency, which is precisely what intensity-based registration algorithms are designed to minimize. Therefore, contrast-enhanced structures typically shrink substantially during registration, which affects the use of the resulting transformation for volumetric analysis, image subtraction, and multispectral classification. A common approach to address this problem is to constrain the deformation. In this paper we present a novel incompressibility constraint approach that is based on the Jacobian determinant of the deformation and can be computed rapidly.We apply our intensity-based non-rigid registration algorithm with this incompressibility constraint to two clinical applications (MR mammography, CT-DSA) and demonstrate that it produces high-quality deformations (as judged by visual assessment) while preserving the volume of contrast-enhanced structures.
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© 2001 Springer-Verlag Berlin Heidelberg
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Rohlfing, T., Maurer, C.R. (2001). Intensity-Based Non-rigid Registration Using Adaptive Multilevel Free-Form Deformation with an Incompressibility Constraint. In: Niessen, W.J., Viergever, M.A. (eds) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2001. MICCAI 2001. Lecture Notes in Computer Science, vol 2208. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45468-3_14
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DOI: https://doi.org/10.1007/3-540-45468-3_14
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