Abstract
This paper introduces a system that processes clinical trials using a combination of natural language processing and database techniques. We process web-based clinical trial recruitment pages to extract semantic information reflecting eligibility criteria for potential participants. From this information we then formulate a query that can match criteria against medical data in patient records. The resulting system reflects a tight coupling of web-based information extraction, natural language processing, medical informatic approaches to clinical knowledge representation, and large-scale database technologies. We present an evaluation of the system and future directions for further system development.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
International Standard ISO/IEC 8824-1. Information technology—Abstract Syntax Notation One (ASN.1): Specification of basic notation. Technical report, International Telecommunications Union, ITU-T Recommendation X.680 (2002)
Hripcsak, G., Clayton, P.D., Pryor, T.A., Haug, P., Wigertz, O.B., Lei, J.v.d.: The Arden Syntax for Medical Logic Modules. In: Miller, R.A. (ed.) Proceedings of the Fourteenth Annual Symposium on Computer Applications in Medical Care, pp. 200–204. IEEE Computer Society Press, Washington (1990)
Huff, S.M., Rocha, R.A., Solbrig, H.R., Barnes, M.W., Schrank, S.P., Smith, M.: Linking a medical vocabulary to a clinical data model using Abstract Syntax Notation 1. Methods of Information in Medicine 37(4-5), 440–452 (1998)
Lindberg, C.: The Unified Medical Language System (UMLS) of the National Library of Medicine. Journal of the American Medical Reccord Association 61(5), 40–42 (1990)
McCray, A.T.: Better access to information about clinical trials. Annals of Internal Medicine 133(8), 609–614 (2000)
Newell, A.: Unified Theories of Cognition. Harvard University Press (1994)
Parker, C.G., Rocha, R.A., Campbell, J.R., Tu, S.W., Huff, S.M.: Detailed clinical models for sharable, executable guidelines. Medinfo 11(Pt 1), 145–148 (2004)
Parker C.: Generating medical logic modules for clinical trial eligibility. Master’s thesis, Brigham Young University (2005)
Rocha, R.A., Huff, S.M., Haug, P.J., Warner, H.R.: Designing a controlled medical vocabulary server: the VOSER project. Computers and Biomedical Research 27(6), 472–507 (1994)
Sleator D., Temperley D.: Parsing English with a link grammar. Technical Report CMU-CS-91-196, Carnegie Mellon University (October 1991)
Spackman, K.A., Campbell, K.E.: Compositional concept representation using SNOMED: Towards further convergence of clinical terminologies. In: Proceedings of the American Medical Informatics Association Annual Symposium, pp. 740–744 (1998)
Szolovits, P.: Adding a medical lexicon to an English parser. In: Proceedings of the American Medical Informatics Association Annual Symposium, pp. 639–643 (2003)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Lonsdale, D., Tustison, C., Parker, C., Embley, D.W. (2006). Formulating Queries for Assessing Clinical Trial Eligibility. In: Kop, C., Fliedl, G., Mayr, H.C., Métais, E. (eds) Natural Language Processing and Information Systems. NLDB 2006. Lecture Notes in Computer Science, vol 3999. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11765448_8
Download citation
DOI: https://doi.org/10.1007/11765448_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-34616-6
Online ISBN: 978-3-540-34617-3
eBook Packages: Computer ScienceComputer Science (R0)