RHO

RHO
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4ZWJ, 5DGY
Dynodwyr
Cyfenwau	RHO, CSNBAD1, OPN2, RP4, rhodopsin, Rhodopsin, visual purple
Dynodwyr allanol	OMIM: 180380 HomoloGene: 68068 GeneCards: RHO
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• signal transducer activity; • metal ion binding; • photoreceptor activity; • GO:0001948, GO:0016582 protein binding; • G protein-coupled receptor activity; • 11-cis retinal binding; • G protein-coupled photoreceptor activity;
Cydrannau o'r gell	• Golgi-associated vesicle membrane; • Golgi apparatus; • Golgi membrane; • photoreceptor outer segment; • cell-cell junction; • integral component of plasma membrane; • bilen; • photoreceptor inner segment; • ciliary membrane; • Cellbilen; • photoreceptor inner segment membrane; • photoreceptor outer segment membrane; • integral component of membrane; • photoreceptor disc membrane; • cell projection;
Prosesau biolegol	• retina development in camera-type eye; • sensory perception of light stimulus; • GO:0072468 signal transduction; • response to stimulus; • detection of light stimulus; • absorption of visible light; • cellular response to light stimulus; • protein phosphorylation; • response to light stimulus; • regulation of rhodopsin mediated signaling pathway; • retinoid metabolic process; • phototransduction; • phototransduction, visible light; • photoreceptor cell maintenance; • golwg; • G protein-coupled receptor signaling pathway; • rhodopsin mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	6010
	n/a
	ENSG00000163914
	n/a
	P08100
	n/a
	NM_000539
	n/a
	NP_000530
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RHO yw RHO a elwir hefyd yn Rhodopsin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3q22.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RHO.

RP4
OPN2
CSNBAD1

Llyfryddiaeth

"Effects of Pathogenic Variations in the Human Rhodopsin Gene (hRHO) on the Predicted Accessibility for a Lead Candidate Ribozyme. ". Invest Ophthalmol Vis Sci. 2017. PMID 28715844.
"Wild-type opsin does not aggregate with a misfolded opsin mutant. ". Biochim Biophys Acta. 2016. PMID 27117643.
"Genetic Analysis of the Rhodopsin Gene Identifies a Mosaic Dominant Retinitis Pigmentosa Mutation in a Healthy Individual. ". Invest Ophthalmol Vis Sci. 2016. PMID 26962691.
"Functional role of positively selected amino acid substitutions in mammalian rhodopsin evolution. ". Sci Rep. 2016. PMID 26865329.
"Identification of a rhodopsin gene mutation in a large family with autosomal dominant retinitis pigmentosa.". Sci Rep. 2016. PMID 26794436.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] RHO - Cronfa NCBI

[1]

[2]