LIMK2

LIMK2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1X6A, 4TPT
Dynodwyr
Cyfenwau	LIMK2, LIM domain kinase 2
Dynodwyr allanol	OMIM: 601988 HomoloGene: 55911 GeneCards: LIMK2
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein serine/threonine kinase activity; • ATP binding; • GO:0001948, GO:0016582 protein binding; • protein heterodimerization activity; • nucleotide binding; • kinase activity; • metal ion binding; • protein kinase activity; • transferase activity; • signal transducer activity;
Cydrannau o'r gell	• cnewyllyn cell; • cytoplasm; • cis-Golgi network;
Prosesau biolegol	• protein phosphorylation; • spermatogenesis; • phosphorylation; • GO:0007243 intracellular signal transduction; • head development; • cornea development in camera-type eye; • actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologau
	3985
	n/a
	ENSG00000182541
	n/a
	P53671
	n/a
	NM_016733; NM_001031801; NM_005569
	n/a
	NP_001026971; NP_005560; NP_057952
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LIMK2 yw LIMK2 a elwir hefyd yn LIM domain kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 22, band 22q12.2.^[2]

Llyfryddiaeth

"LIMK2 mediates resistance to chemotherapeutic drugs in neuroblastoma cells through regulation of drug-induced cell cycle arrest. ". PLoS One. 2013. PMID 23991158.
"Phosphorylation-dependent regulation of unique nuclear and nucleolar localization signals of LIM kinase 2 in endothelial cells. ". J Biol Chem. 2006. PMID 16820362.
"Cloning and characterization of the alternative promoter regions of the human LIMK2 gene responsible for alternative transcripts with tissue-specific expression. ". Gene. 1999. PMID 10452946.
"Subcellular localization and protein interaction of the human LIMK2 gene expressing alternative transcripts with tissue-specific regulation. ". Biochem Biophys Res Commun. 1996. PMID 8954941.
"Whole Exome Sequencing Identifies Rare Protein-Coding Variants in BehÃ§et's Disease.". Arthritis Rheumatol. 2016. PMID 26662719.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] LIMK2 - Cronfa NCBI

[1]

[2]