KDR

KDR
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1VR2, 1Y6A, 1Y6B, 1YWN, 2M59, 2MET, 2MEU, 2OH4, 2P2H, 2P2I, 2QU5, 2QU6, 2RL5, 2X1W, 2X1X, 2XIR, 3B8Q, 3B8R, 3BE2, 3C7Q, 3CJF, 3CJG, 3CP9, 3CPB, 3CPC, 3DTW, 3EFL, 3EWH, 3KVQ, 3S35, 3S36, 3S37, 3U6J, 3VHE, 3VHK, 3VID, 3VNT, 3VO3, 3WZD, 3WZE, 4AG8, 4AGC, 4AGD, 4ASD, 4ASE, 5EW3
Dynodwyr
Cyfenwau	KDR, CD309, FLK1, VEGFR, VEGFR2, Kinase insert domain receptor
Dynodwyr allanol	OMIM: 191306 HomoloGene: 55639 GeneCards: KDR
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • Hsp90 protein binding • nucleotide binding • protein kinase activity • growth factor binding • vascular endothelial growth factor binding • kinase activity • integrin binding • GO:0001948, GO:0016582 protein binding • ATP binding • transmembrane receptor protein tyrosine kinase activity • vascular endothelial growth factor-activated receptor activity • protein tyrosine kinase activity • identical protein binding • receptor tyrosine kinase • transmembrane signaling receptor activity • cadherin binding Cydrannau o'r gell • cytoplasm • integral component of membrane • Golgi apparatus • bilen • integral component of plasma membrane • extracellular region • cell junction • early endosome • membrane raft • sorting endosome • GO:0016023 cytoplasmic vesicle • cnewyllyn cell • endosome • Cellbilen • Reticwlwm endoplasmig • receptor complex Prosesau biolegol • negative regulation of endothelial cell apoptotic process • cell differentiation • positive regulation of protein phosphorylation • positive regulation of mitochondrial fission • positive regulation of endothelial cell proliferation • phosphorylation • extracellular matrix organization • negative regulation of apoptotic process • positive regulation of nitric-oxide synthase biosynthetic process • cell migration involved in sprouting angiogenesis • positive regulation of angiogenesis • vasculogenesis • positive regulation of endothelial cell migration • multicellular organism development • protein phosphorylation • positive regulation of macroautophagy • positive regulation of mitochondrial depolarization • positive regulation of vasculogenesis • embryonic hemopoiesis • endothelium development • regulation of cell shape • positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway • positive regulation of ERK1 and ERK2 cascade • peptidyl-tyrosine autophosphorylation • protein autophosphorylation • positive regulation of focal adhesion assembly • positive regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • cellular response to vascular endothelial growth factor stimulus • GO:0022415 viral process • calcium-mediated signaling using intracellular calcium source • positive regulation of MAPK cascade • positive regulation of positive chemotaxis • transmembrane receptor protein tyrosine kinase signaling pathway • vascular endothelial growth factor receptor signaling pathway • positive regulation of cell population proliferation • angiogenesis • positive regulation of cell migration • protein kinase B signaling • ERK1 and ERK2 cascade • negative regulation of gene expression • positive regulation of blood vessel endothelial cell migration • cellular response to hydrogen sulfide • positive regulation of cell migration involved in sprouting angiogenesis • negative regulation of signal transduction • sprouting angiogenesis • cell migration • endothelial cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3791	n/a
Ensembl	ENSG00000128052	n/a
UniProt	P35968	n/a
RefSeq (mRNA)	NM_002253	n/a
RefSeq (protein)	NP_002244	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KDR yw KDR a elwir hefyd yn Kinase insert domain receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KDR.

• FLK1
• CD309
• VEGFR
• VEGFR2

Llyfryddiaeth

• "Determination of VEGFR-2 (KDR) 604A>G Polymorphism in Pancreatic Disorders. ". Int J Mol Sci. 2017. PMID 28218664.
• "Dysregulation of Vascular Endothelial Growth Factor Receptor-2 by Multiple miRNAs in Endothelial Colony-Forming Cells of Coronary Artery Disease. ". J Vasc Res. 2017. PMID 28122380.
• "Vascular Endothelial Growth Factor Receptor-2 Polymorphisms Have Protective Effect against the Development of Tendinopathy in Volleyball Athletes. ". PLoS One. 2016. PMID 27930691.
• "Mechanisms and regulation of endothelial VEGF receptor signalling. ". Nat Rev Mol Cell Biol. 2016. PMID 27461391.
• "Whole exome sequencing in families at high risk for Hodgkin lymphoma: identification of a predisposing mutation in the KDR gene.". Haematologica. 2016. PMID 27365461.