GP1BA

GP1BA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GWB, 1M0Z, 1M10, 1OOK, 1P8V, 1P9A, 1QYY, 1SQ0, 1U0N, 2BP3, 3P72, 3PMH, 4C2A, 4C2B, 4CH2, 4CH8, 4MGX, 4YR6
Dynodwyr
Cyfenwau	GP1BA, BDPLT1, BDPLT3, BSS, CD42B, CD42b-alpha, DBPLT3, GP1B, GPIbA, VWDP, GPIbalpha, glycoprotein Ib platelet alpha subunit, glycoprotein Ib platelet subunit alpha
Dynodwyr allanol	OMIM: 606672 HomoloGene: 143 GeneCards: GP1BA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein kinase inhibitor activity • thrombin-activated receptor activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • integral component of membrane • bilen • Cellbilen • integral component of plasma membrane • cell surface • anchored component of external side of plasma membrane • extracellular exosome • extracellular space • GO:0005578 extracellular matrix Prosesau biolegol • blood coagulation, intrinsic pathway • hemostasis • fibrinolysis • negative regulation of protein kinase activity • cytokine-mediated signaling pathway • blood coagulation • platelet activation • cell surface receptor signaling pathway • cell adhesion • GO:0000767 cell morphogenesis • regulation of blood coagulation • negative regulation of receptor signaling pathway via JAK-STAT • thrombin-activated receptor signaling pathway • platelet aggregation • regulation of megakaryocyte differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2811	n/a
Ensembl	ENSG00000185245	n/a
UniProt	P07359	n/a
RefSeq (mRNA)	NM_000173	n/a
RefSeq (protein)	NP_000164	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GP1BA yw GP1BA a elwir hefyd yn Glycoprotein Ib platelet alpha subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17p13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GP1BA.

• BSS
• GP1B
• VWDP
• CD42B
• GPIbA
• BDPLT1
• BDPLT3
• DBPLT3
• GPIbalpha
• CD42b-alpha

Llyfryddiaeth

• "Inhibiting GPIbα Shedding Preserves Post-Transfusion Recovery and Hemostatic Function of Platelets After Prolonged Storage. ". Arterioscler Thromb Vasc Biol. 2016. PMID 27417583.
• "Dimerization of glycoprotein Ibα is not sufficient to induce platelet clearance. ". J Thromb Haemost. 2016. PMID 26662889.
• "[The molecular mechanisms of platelets activation in patients with cerebrovascular disease]. ". Biomed Khim. 2015. PMID 26539867.
• "Hemoglobin interaction with GP1bα induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis. ". Haematologica. 2015. PMID 26341739.
• "Association between polymorphisms of platelet membrane glycoprotein Ibα and risk of coronary heart disease in Han Chinese, Henan, China.". Int J Clin Exp Pathol. 2015. PMID 26191334.