F8

F8
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1CFG, 1D7P, 1IQD, 2R7E, 3CDZ, 3HNB, 3HNY, 3HOB, 4BDV, 1FAC, 3J2Q, 3J2S, 4KI5, 4PT6, 4XZU
Dynodwyr
Cyfenwau	F8, AHF, DXS1253E, F8B, F8C, FVIII, HEMA, coagulation factor VIII, THPH13
Dynodwyr allanol	OMIM: 300841 HomoloGene: 49153 GeneCards: F8
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • GO:0001948, GO:0016582 protein binding • oxidoreductase activity • copper ion binding Cydrannau o'r gell • endoplasmic reticulum lumen • Cellbilen • extracellular region • COPII-coated ER to Golgi transport vesicle • endoplasmic reticulum-Golgi intermediate compartment membrane • platelet alpha granule lumen • Golgi membrane • extracellular space Prosesau biolegol • hemostasis • platelet degranulation • blood coagulation • endoplasmic reticulum to Golgi vesicle-mediated transport • COPII vesicle coating • acute-phase response • blood coagulation, intrinsic pathway • platelet activation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2157	n/a
Ensembl	ENSG00000185010	n/a
UniProt	P00451	n/a
RefSeq (mRNA)	NM_000132 NM_019863	n/a
RefSeq (protein)	NP_000123 NP_063916	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn F8 yw F8 a elwir hefyd yn Coagulation factor VIII (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom X dynol, band Xq28.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn F8.

• AHF
• F8B
• F8C
• HEMA
• FVIII
• DXS1253E

Llyfryddiaeth

• "[Genetic and prenatal diagnosis for a haemophilia A family with two novel mutations of F8 gene]. ". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017. PMID 28777843.
• "Cellular uptake of coagulation factor VIII: Elusive role of the membrane-binding spikes in the C1 domain. ". Int J Biochem Cell Biol. 2017. PMID 28558995.
• "Frequency and epitope specificity of anti-factor VIII C1 domain antibodies in acquired and congenital hemophilia A. ". Blood. 2017. PMID 28507083.
• "Biological considerations of plasma-derived and recombinant factor VIII immunogenicity. ". Blood. 2017. PMID 28432221.
• "[Genetic analysis for a family affected with hemophilia type A due to a large deletion of F8 gene].". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016. PMID 27984605.