CDK6

CDK6
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1BI7, 1BI8, 1BLX, 1G3N, 1JOW, 1XO2, 2EUF, 2F2C, 3NUP, 3NUX, 4AUA, 4EZ5, 4TTH
Dynodwyr
Cyfenwau	CDK6, MCPH12, PLSTIRE, cyclin-dependent kinase 6, cyclin dependent kinase 6
Dynodwyr allanol	OMIM: 603368 HomoloGene: 963 GeneCards: CDK6
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • protein kinase activity; • nucleotide binding; • cyclin-dependent protein serine/threonine kinase activity; • kinase activity; • protein serine/threonine kinase activity; • GO:0001948, GO:0016582 protein binding; • ATP binding; • cyclin binding; • FBXO family protein binding;
Cydrannau o'r gell	• cytoplasm; • centrosome; • cell projection; • cyclin-dependent protein kinase holoenzyme complex; • ruffle; • microtubule organizing center; • Cytosgerbwd; • cnewyllyn cell; • cytosol; • nucleoplasm; • cyclin D2-CDK6 complex;
Prosesau biolegol	• cell differentiation; • lateral ventricle development; • phosphorylation; • positive regulation of cell-matrix adhesion; • positive regulation of fibroblast proliferation; • dentate gyrus development; • regulation of erythrocyte differentiation; • astrocyte development; • negative regulation of cell differentiation; • response to virus; • negative regulation of cell cycle; • negative regulation of osteoblast differentiation; • generation of neurons; • Cellraniad; • regulation of cell motility; • protein phosphorylation; • negative regulation of epithelial cell proliferation; • regulation of gene expression; • cell cycle; • type B pancreatic cell development; • negative regulation of myeloid cell differentiation; • negative regulation of cellular senescence; • gliogenesis; • negative regulation of cell population proliferation; • negative regulation of monocyte differentiation; • GO:0072468 signal transduction; • regulation of G2/M transition of mitotic cell cycle; • regulation of cell population proliferation; • cell dedifferentiation; • G1/S transition of mitotic cell cycle; • GO:1901227 negative regulation of transcription by RNA polymerase II; • hematopoietic progenitor cell differentiation; • Notch signaling pathway; • GO:1901313 positive regulation of gene expression; • hemopoiesis; • T cell differentiation in thymus; • hematopoietic stem cell differentiation; • regulation of hematopoietic stem cell differentiation; • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologau
	1021
	n/a
	ENSG00000105810
	n/a
	Q00534
	n/a
	NM_001145306; NM_001259
	n/a
	NP_001138778; NP_001250
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDK6 yw CDK6 a elwir hefyd yn Cyclin dependent kinase 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q21.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDK6.

MCPH12
PLSTIRE

Llyfryddiaeth

"Palbociclib can overcome mutations in cyclin dependent kinase 6 that break hydrogen bonds between the drug and the protein. ". Protein Sci. 2017. PMID 28168755.
"CDK6 levels regulate quiescence exit in human hematopoietic stem cells. ". Cell Stem Cell. 2015. PMID 25704240.
"LINE-1 methylation level and patient prognosis in a database of 208 hepatocellular carcinomas. ". Ann Surg Oncol. 2015. PMID 25319577.
"Requirement for CDK6 in MLL-rearranged acute myeloid leukemia. ". Blood. 2014. PMID 24764564.
"MLL fusion-driven activation of CDK6 potentiates proliferation in MLL-rearranged infant ALL.". Cell Cycle. 2014. PMID 24736461.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CDK6 - Cronfa NCBI

[1]

[2]