ACTN3

ACTN3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1TJT, 1WKU, 3LUE
Dynodwyr
Cyfenwau	ACTN3, actinin alpha 3 (gene/pseudogene), ACTN3D, actinin alpha 3
Dynodwyr allanol	OMIM: 102574 GeneCards: ACTN3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • protein homodimerization activity • transmembrane transporter binding • metal ion binding • integrin binding • GO:0001948, GO:0016582 protein binding • actin binding • structural constituent of muscle Cydrannau o'r gell • cytosol • pseudopodium • focal adhesion • intracellular anatomical structure • Microffilament • extracellular exosome Prosesau biolegol • regulation of apoptotic process • regulation of aerobic respiration • negative regulation of glycolytic process • negative regulation of calcineurin-NFAT signaling cascade • transition between fast and slow fiber • positive regulation of glucose catabolic process to lactate via pyruvate • focal adhesion assembly • muscle filament sliding • skeletal muscle atrophy • response to denervation involved in regulation of muscle adaptation • negative regulation of oxidative phosphorylation • positive regulation of skeletal muscle tissue growth • regulation of the force of skeletal muscle contraction • negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	89	n/a
Ensembl	ENSG00000248746	n/a
UniProt	Q08043	n/a
RefSeq (mRNA)	NM_001104 NM_001258371	n/a
RefSeq (protein)	NP_001095 NP_001245300	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ACTN3 yw ACTN3 a elwir hefyd yn Actinin alpha 3 (gene/pseudogene) (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ACTN3.

• ACTN3D

Llyfryddiaeth

• "Association between ACTN3 R577X Polymorphism and Trunk Flexibility in 2 Different Cohorts. ". Int J Sports Med. 2017. PMID 28303562.
• "The influence of α-actinin-3 deficiency on bone remodelling markers in young men. ". Bone. 2017. PMID 28254467.
• "ACTN3 genotype influences exercise-induced muscle damage during a marathon competition. ". Eur J Appl Physiol. 2017. PMID 28154975.
• "Genetic association between ACTN3 polymorphism and risk of non-acute ankle sprain. ". Genet Mol Res. 2016. PMID 27966742.
• "ACTN3 X-allele carriers had greater levels of muscle damage during a half-ironman.". Eur J Appl Physiol. 2017. PMID 27913923.