Personalized medicine combines a patient’s genetic and genomic information with their family history, lifestyle, and environmental factors to make better predictions about their risk for disease or response to prescription drugs and to tailor treatments for their improved health. To explore the use of genomic information in clinical decision-making, the Coriell Personalized Medicine Collaborative® (CPMC®) was initiated in 2007. This research study is a multi-party endeavor of volunteer study participants, physicians, scientists, ethicists, genetic counselors, pharmacists, information technologists, and hospital and academic partners. Thousands of CPMC study participants have viewed their genetic and non-genetic risks for disease and drug response. How their lifestyle behaviors change – and whether they choose to share their results and with whom – is revealing the utility of genetic information in clinical care.