We report new experimental data on the mass loss kinetics and associated isotope fractionation of... more We report new experimental data on the mass loss kinetics and associated isotope fractionation of residues of molten Type B1 CAI samples evaporated at different temperatures, pressures, and gas compositions.
We have evaporated melts of CAI composition doped with trace elements in 0.0001 atm H2. The lack ... more We have evaporated melts of CAI composition doped with trace elements in 0.0001 atm H2. The lack of Ce anomalies in residues shows that CAIs with large negative Ce anomalies cannot have evaporated in the solar nebula.
Genetic interactions play a critical role in cancer development. Existing knowledge about cancer ... more Genetic interactions play a critical role in cancer development. Existing knowledge about cancer genetic interactions is incomplete, especially lacking evidences derived from large-scale cancer genomics data. The Cancer Genome Atlas (TCGA) produces multimodal measurements across genomics and features of thousands of tumors, which provide an unprecedented opportunity to investigate the interplays of genes in cancer. We introduce Zodiac, a computational tool and resource to integrate existing knowledge about cancer genetic interactions with new information contained in TCGA data. It is an evolution of existing knowledge by treating it as a prior graph, integrating it with a likelihood model derived by Bayesian graphical model based on TCGA data, and producing a posterior graph as updated and data-enhanced knowledge. In short, Zodiac realizes "Prior interaction map + TCGA data → Posterior interaction map." Zodiac provides molecular interactions for about 200 million pairs of ...
Studies in Health Technology and Informatics, Feb 1, 2007
For more than a decade, various approaches have been taken to teach anatomy using immersive virtu... more For more than a decade, various approaches have been taken to teach anatomy using immersive virtual reality. This is the first complete anatomy course we are aware of which directly substitutes immersive virtual reality via stereo volume visualization of clinical radiological datasets for cadaver dissection. The students valued highly the new approach and the overall course was very well received. Students performed well on examinations. The course efficiently added human anatomy to the University of Chicago undergraduate biology electives.
PURPOSE/AIM 1. To introduce standards based Patient Centric Authorization (PCA) model based on X.... more PURPOSE/AIM 1. To introduce standards based Patient Centric Authorization (PCA) model based on X.509 certificates and SAML assertions. PCA allows secure and HIPAA compliant cross enterprise healthcare information exchange, storage, and management. 2. To present hands-on Enterprise PACS image workflow in PCA enabled HealthGrids CONTENT ORGANIZATION - Protected health information requires HCPs to secure data when sharing. PCA presents a standards based solution to cross-enterprise image exchange using Grid technology. - Integration of Grid technology in the healthcare requires compliance to DICOM and other standards. Open-source Globus MEDICUS integrates DICOM modalities into PCA protected HealthGrids. - Grid based DICOM publication/discovery for information exchange also provides FT and DR capabilities using storage replication management. SUMMARY 1. How standards based open-source Grid technology can be used to solve securing PHI for image exchange, storage, and management. 2. How P...
Genetic interactions play a critical role in cancer development. Existing knowledge about cancer ... more Genetic interactions play a critical role in cancer development. Existing knowledge about cancer genetic interactions is incomplete, especially lacking evidences derived from large-scale cancer genomics data. The Cancer Genome Atlas (TCGA) produces multimodal measurements across genomics and features of thousands of tumors, which provide an unprecedented opportunity to investigate the interplays of genes in cancer. We introduce Zodiac, a computational tool and resource to integrate existing knowledge about cancer genetic interactions with new information contained in TCGA data. It is an evolution of existing knowledge by treating it as a prior graph, integrating it with a likelihood model derived by Bayesian graphical model based on TCGA data, and producing a posterior graph as updated and data-enhanced knowledge. In short, Zodiac realizes "Prior interaction map + TCGA data → Posterior interaction map." Zodiac provides molecular interactions for about 200 million pairs of ...
Proceedings of the ACM international conference on Health informatics - IHI '10, 2010
Vast amounts of multimodal imaging data are continuously generated in medicine. 3D and 3D stereos... more Vast amounts of multimodal imaging data are continuously generated in medicine. 3D and 3D stereoscopic visualization have become indispensable methods for health care professionals to effectively analyze and communicate this data in the clinical, research, and educational domains. The current visualization paradigm in health care confines 3D rendering to proprietary medical imaging workstations commonly housed in radiology departments or to
Studies in health technology and informatics, 2007
For more than a decade, various approaches have been taken to teach anatomy using immersive virtu... more For more than a decade, various approaches have been taken to teach anatomy using immersive virtual reality. This is the first complete anatomy course we are aware of which directly substitutes immersive virtual reality via stereo volume visualization of clinical radiological datasets for cadaver dissection. The students valued highly the new approach and the overall course was very well received. Students performed well on examinations. The course efficiently added human anatomy to the University of Chicago undergraduate biology electives.
Studies in health technology and informatics, 2008
Many prototype projects aspire to develop a sustainable model of immersive radiological volume vi... more Many prototype projects aspire to develop a sustainable model of immersive radiological volume visualization for virtual anatomic education. Some have focused on distributed or parallel architectures. However, very few, if any others, have combined multi-location, multi-directional, multi-stream sharing of video, audio, desktop applications, and parallel stereo volume rendering, to converge on an open, globally scalable, and inexpensive collaborative architecture and implementation method for anatomic teaching using radiological volumes. We have focused our efforts on bringing this all together for several years. We outline here the technology we're making available to the open source community and a system implementation suggestion for how to create global immersive virtual anatomy classrooms. With the releases of Access Grid 3.1 and our parallel stereo volume rendering code, inexpensive globally scalable technology is available to enable collaborative volume visualization upon...
Studies in health technology and informatics, 2011
Many projects have focused on the improvement of virtual education. We have contributed with the ... more Many projects have focused on the improvement of virtual education. We have contributed with the global virtual anatomy course for teaching students in multiple locations with stereoscopic volume rendering, audio/video conferencing and additional materials. This year we focused on further simplifying the deployment of the classroom by using the new collaborative and web-based visualization system CoWebViz, to transfer stereoscopic visualization to the classrooms. Besides the necessary hardware installations for stereoscopy, only a web browser is necessary to view and to interact with the remote 3D stereo visualization. This system proved stable, gave higher quality images and increased ease of deployment. Its success within our classroom at the University of Chicago and Cardiff University has motivated us to continue CoWebViz development.
Our objective was to investigate the application of three-dimensional (3D) stereoscopic volume re... more Our objective was to investigate the application of three-dimensional (3D) stereoscopic volume rendering with perceptual colorization on preoperative imaging for malignant pleural mesothelioma. At present, we have prospectively enrolled 6 patients being considered for resection of malignant pleural mesothelioma that have undergone a multidetector-row computed tomography (CT) scan of the chest. The CT data sets were volume rendered without preprocessing. The resultant 3D rendering was displayed stereoscopically and used to provide information regarding tumor extent, morphology, and anatomic involvement. To demonstrate this technique, this information was compared with the corresponding two-dimensional CT grayscale axial images from two of these patients. Three-dimensional stereoscopic reconstructions of the CT data sets provided detailed information regarding the local extent of tumor that could be used for preoperative surgical planning. Three-dimensional stereoscopic volume rendering for malignant pleural mesothelioma is a novel approach. Combined with our innovative perceptual colorization algorithm, stereoscopic volumetric analysis potentially allows for the accurate determination of the extent of pleural mesothelioma with results difficult to duplicate using grayscale, multiplanar CT images.
We report new experimental data on the mass loss kinetics and associated isotope fractionation of... more We report new experimental data on the mass loss kinetics and associated isotope fractionation of residues of molten Type B1 CAI samples evaporated at different temperatures, pressures, and gas compositions.
We have evaporated melts of CAI composition doped with trace elements in 0.0001 atm H2. The lack ... more We have evaporated melts of CAI composition doped with trace elements in 0.0001 atm H2. The lack of Ce anomalies in residues shows that CAIs with large negative Ce anomalies cannot have evaporated in the solar nebula.
Genetic interactions play a critical role in cancer development. Existing knowledge about cancer ... more Genetic interactions play a critical role in cancer development. Existing knowledge about cancer genetic interactions is incomplete, especially lacking evidences derived from large-scale cancer genomics data. The Cancer Genome Atlas (TCGA) produces multimodal measurements across genomics and features of thousands of tumors, which provide an unprecedented opportunity to investigate the interplays of genes in cancer. We introduce Zodiac, a computational tool and resource to integrate existing knowledge about cancer genetic interactions with new information contained in TCGA data. It is an evolution of existing knowledge by treating it as a prior graph, integrating it with a likelihood model derived by Bayesian graphical model based on TCGA data, and producing a posterior graph as updated and data-enhanced knowledge. In short, Zodiac realizes "Prior interaction map + TCGA data → Posterior interaction map." Zodiac provides molecular interactions for about 200 million pairs of ...
Studies in Health Technology and Informatics, Feb 1, 2007
For more than a decade, various approaches have been taken to teach anatomy using immersive virtu... more For more than a decade, various approaches have been taken to teach anatomy using immersive virtual reality. This is the first complete anatomy course we are aware of which directly substitutes immersive virtual reality via stereo volume visualization of clinical radiological datasets for cadaver dissection. The students valued highly the new approach and the overall course was very well received. Students performed well on examinations. The course efficiently added human anatomy to the University of Chicago undergraduate biology electives.
PURPOSE/AIM 1. To introduce standards based Patient Centric Authorization (PCA) model based on X.... more PURPOSE/AIM 1. To introduce standards based Patient Centric Authorization (PCA) model based on X.509 certificates and SAML assertions. PCA allows secure and HIPAA compliant cross enterprise healthcare information exchange, storage, and management. 2. To present hands-on Enterprise PACS image workflow in PCA enabled HealthGrids CONTENT ORGANIZATION - Protected health information requires HCPs to secure data when sharing. PCA presents a standards based solution to cross-enterprise image exchange using Grid technology. - Integration of Grid technology in the healthcare requires compliance to DICOM and other standards. Open-source Globus MEDICUS integrates DICOM modalities into PCA protected HealthGrids. - Grid based DICOM publication/discovery for information exchange also provides FT and DR capabilities using storage replication management. SUMMARY 1. How standards based open-source Grid technology can be used to solve securing PHI for image exchange, storage, and management. 2. How P...
Genetic interactions play a critical role in cancer development. Existing knowledge about cancer ... more Genetic interactions play a critical role in cancer development. Existing knowledge about cancer genetic interactions is incomplete, especially lacking evidences derived from large-scale cancer genomics data. The Cancer Genome Atlas (TCGA) produces multimodal measurements across genomics and features of thousands of tumors, which provide an unprecedented opportunity to investigate the interplays of genes in cancer. We introduce Zodiac, a computational tool and resource to integrate existing knowledge about cancer genetic interactions with new information contained in TCGA data. It is an evolution of existing knowledge by treating it as a prior graph, integrating it with a likelihood model derived by Bayesian graphical model based on TCGA data, and producing a posterior graph as updated and data-enhanced knowledge. In short, Zodiac realizes "Prior interaction map + TCGA data → Posterior interaction map." Zodiac provides molecular interactions for about 200 million pairs of ...
Proceedings of the ACM international conference on Health informatics - IHI '10, 2010
Vast amounts of multimodal imaging data are continuously generated in medicine. 3D and 3D stereos... more Vast amounts of multimodal imaging data are continuously generated in medicine. 3D and 3D stereoscopic visualization have become indispensable methods for health care professionals to effectively analyze and communicate this data in the clinical, research, and educational domains. The current visualization paradigm in health care confines 3D rendering to proprietary medical imaging workstations commonly housed in radiology departments or to
Studies in health technology and informatics, 2007
For more than a decade, various approaches have been taken to teach anatomy using immersive virtu... more For more than a decade, various approaches have been taken to teach anatomy using immersive virtual reality. This is the first complete anatomy course we are aware of which directly substitutes immersive virtual reality via stereo volume visualization of clinical radiological datasets for cadaver dissection. The students valued highly the new approach and the overall course was very well received. Students performed well on examinations. The course efficiently added human anatomy to the University of Chicago undergraduate biology electives.
Studies in health technology and informatics, 2008
Many prototype projects aspire to develop a sustainable model of immersive radiological volume vi... more Many prototype projects aspire to develop a sustainable model of immersive radiological volume visualization for virtual anatomic education. Some have focused on distributed or parallel architectures. However, very few, if any others, have combined multi-location, multi-directional, multi-stream sharing of video, audio, desktop applications, and parallel stereo volume rendering, to converge on an open, globally scalable, and inexpensive collaborative architecture and implementation method for anatomic teaching using radiological volumes. We have focused our efforts on bringing this all together for several years. We outline here the technology we're making available to the open source community and a system implementation suggestion for how to create global immersive virtual anatomy classrooms. With the releases of Access Grid 3.1 and our parallel stereo volume rendering code, inexpensive globally scalable technology is available to enable collaborative volume visualization upon...
Studies in health technology and informatics, 2011
Many projects have focused on the improvement of virtual education. We have contributed with the ... more Many projects have focused on the improvement of virtual education. We have contributed with the global virtual anatomy course for teaching students in multiple locations with stereoscopic volume rendering, audio/video conferencing and additional materials. This year we focused on further simplifying the deployment of the classroom by using the new collaborative and web-based visualization system CoWebViz, to transfer stereoscopic visualization to the classrooms. Besides the necessary hardware installations for stereoscopy, only a web browser is necessary to view and to interact with the remote 3D stereo visualization. This system proved stable, gave higher quality images and increased ease of deployment. Its success within our classroom at the University of Chicago and Cardiff University has motivated us to continue CoWebViz development.
Our objective was to investigate the application of three-dimensional (3D) stereoscopic volume re... more Our objective was to investigate the application of three-dimensional (3D) stereoscopic volume rendering with perceptual colorization on preoperative imaging for malignant pleural mesothelioma. At present, we have prospectively enrolled 6 patients being considered for resection of malignant pleural mesothelioma that have undergone a multidetector-row computed tomography (CT) scan of the chest. The CT data sets were volume rendered without preprocessing. The resultant 3D rendering was displayed stereoscopically and used to provide information regarding tumor extent, morphology, and anatomic involvement. To demonstrate this technique, this information was compared with the corresponding two-dimensional CT grayscale axial images from two of these patients. Three-dimensional stereoscopic reconstructions of the CT data sets provided detailed information regarding the local extent of tumor that could be used for preoperative surgical planning. Three-dimensional stereoscopic volume rendering for malignant pleural mesothelioma is a novel approach. Combined with our innovative perceptual colorization algorithm, stereoscopic volumetric analysis potentially allows for the accurate determination of the extent of pleural mesothelioma with results difficult to duplicate using grayscale, multiplanar CT images.
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