LCORL

LCORL
Identifikatori
Aliasi	LCORL
Vanjski ID-jevi	OMIM: 611799 MGI: 2651932 HomoloGene: 82325 GeneCards: LCORL
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	18,021,876 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	45,857,615 bp
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • GO:0001948, GO:0016582 vezivanje za proteine; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• jedro;
Biološki proces	• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • GO:0009373 regulation of transcription, DNA-templated; • transcription by RNA polymerase II; • transcription, DNA-templated;
	Izvori:Amigo / QuickGO
Ortolozi
	254251
	209707
	ENSG00000178177
	ENSMUSG00000015882
	Q8N3X6
	Q3U285
	NM_001166139; NM_153686
NM_001163073; NM_172153; NM_178142; NM_001359871; NM_001359872;
	NM_001359873; NM_001359874
NP_001159611; NP_710153; NP_001352587; NP_001352588; NP_001352589;
	NP_001352590; NP_001352591; NP_001352592; NP_001352594
NP_001156545; NP_742165; NP_835278; NP_001346800; NP_001346801;
	NP_001346802; NP_001346803
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Korepresoliki ligand-ovisni jedarni receptor jest protein koji je kod ljudi kodiran genom LCOR sa hromosoma 4.^[5]

Transkripcijski faktori imaju ključnu ulogu u regulaciji razvoja i funkcija nervnog sistema. Transkripcijski faktor Mblk-1 je prethodno prijavljen na ekranu za faktore koji su možda važni za više moždane funkcije pčele. Upregledu iz 2003. ovaj gen posmatran je u vezi sa ekspresijom Mblk-1 koji je identificiran, a zatim daje razmatra i njihove homolog. Proteini porodice Mblk-1 se široko nalaze u životinjama i pokazalo se da utiču na aktivnosti transkripcije. Studije su otkrile da homolozi sisara mogu komunicirati s nekoliko kofaktora i zajedno regulirati transkripciju. Zanimljivo je da je nedavna studija koja je koristila mišje homologe, Mlr1 i Mlr2, pokazala da jedan od njihovih kofaktorskih proteina, NOL4, ima nekoliko varijanti spajanja s različitim efektima na aktivnosti transaktivacije Mlr proteina. Ovi nalazi sugeriraju da postoji dodatni sloj regulacije proteina porodice Mblk-1 varijantama transkripta kofaktora i daju novi uvid u dotadašnje razumijevanje uloga porodice konzerviranih transkripcijskih faktora.^[6]

Funkcija

Ovaj gen kodira transkripcijski faktor za koji funkcionira u spermatogenezi. Polimorfizmi u ovom genu su povezani sa mjerama veličine skeletnog okvira i visine odrasle osobe. Alternativna prerada rezultira višestrukim varijantama transkripta.

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178177 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015882 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Ligand dependent nuclear receptor corepressor like". Pristupljeno 11. 11. 2016.
^ Kunieda T, Park JM, Takeuchi H, Kubo T (2003). "Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1)". FEBS Lett. 535 (1–3): 61–5. doi:10.1016/s0014-5793(02)03858-9. PMID 12560079. S2CID 83745027.

Dopunska literatura

Sovio, U; Bennett, AJ; Millwood, IY; Molitor, J; O'Reilly, PF; Timpson, NJ; Kaakinen, M; Laitinen, J; Haukka, J; Pillas, D; Tzoulaki, I; Molitor, J; Hoggart, C; Coin, LJ; Whittaker, J; Pouta, A; Hartikainen, AL; Freimer, NB; Widen, E; Peltonen, L; Elliott, P; McCarthy, MI; Jarvelin, MR (mart 2009). "Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966". PLOS Genetics. 5 (3): e1000409. doi:10.1371/journal.pgen.1000409. PMC 2646138. PMID 19266077.
Soranzo N, Rivadeneira F, Chinappen-Horsley U, Malkina I, Richards JB, Hammond N, Stolk L, Nica A, Inouye M, Hofman A, Stephens J, Wheeler E, Arp P, Gwilliam R, Jhamai PM, Potter S, Chaney A, Ghori MJ, Ravindrarajah R, Ermakov S, Estrada K, Pols HA, Williams FM, McArdle WL, van Meurs JB, Loos RJ, Dermitzakis ET, Ahmadi KR, Hart DJ, Ouwehand WH, Wareham NJ, Barroso I, Sandhu MS, Strachan DP, Livshits G, Spector TD, Uitterlinden AG, Deloukas P (2009). "Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size". PLOS Genet. 5 (4): e1000445. doi:10.1371/journal.pgen.1000445. PMC 2661236. PMID 19343178.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178177 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015882 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Ligand dependent nuclear receptor corepressor like". Pristupljeno 11. 11. 2016.

[6] Kunieda T, Park JM, Takeuchi H, Kubo T (2003). "Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1)". FEBS Lett. 535 (1–3): 61–5. doi:10.1016/s0014-5793(02)03858-9. PMID 12560079. S2CID 83745027.

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