Recently, lower maternal plasma human leukocyte antigen (HLA)-G protein levels in preeclampsia (PE) in the first and second trimester was reported. Thus, we sought to evaluate the levels of HLA-G protein in patients with severe PE during... more
Recently, lower maternal plasma human leukocyte antigen (HLA)-G protein levels in preeclampsia (PE) in the first and second trimester was reported. Thus, we sought to evaluate the levels of HLA-G protein in patients with severe PE during the third trimester. In this prospective case control study, amniotic fluid and maternal and cord blood samples were aspirated from 50 pregnant women during the third trimester. The study group included 26 pregnant women diagnosed with severe PE and 24 women without PE serving as controls. A soluble HLA-G-specific enzyme-linked immunosorbent assay was used to measure protein levels. Statistical analysis included the Student t test and simple regression analysis. Maternal serum HLA-G levels in PE pregnancies were found to be significantly lower as compared with normal pregnancies (10.97 +/- 6.55 vs 36.05 +/- 34.53 microg/mL; P = .003). A reduced level of maternal HLA-G protein was associated with severe PE during the third trimester. This finding may...
Research Interests:
We present a case of a 24-year old, otherwise healthy, primigravida that was admitted at term with severe abdominal pain, hemoperitoneum, hypovolemic shock and severe fetal bradycardia. There was no history of abdominal trauma. Due to... more
We present a case of a 24-year old, otherwise healthy, primigravida that was admitted at term with severe abdominal pain, hemoperitoneum, hypovolemic shock and severe fetal bradycardia. There was no history of abdominal trauma. Due to suspected fetal distress and placental abruption an emergency cesarean section was performed. Careful exploration of the abdominal cavity, uterus and placenta did not reveal the origin of hemorrhage, placental abruption was ruled out. Idiopathic spontaneous hemoperitoneum is a rare and life threatening condition. The origin of the hemorrhage often remains obscure, even after a thorough workup. To the best of our knowledge, this is the first case of idiopathic spontaneous hemoperitoneum reported in a pregnant patient at term. A review of the literature was undertaken.
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Research Interests:
... Correspondence to Dr David Chitayat, MD, Department of Obstetrics and Gynecology, The Prenatal Diagnosis and Medical Genetics Program, The Ontario Power Generation Building, 700 University Avenue, Room 3292 ... Uygur D, Kis S, Sener... more
... Correspondence to Dr David Chitayat, MD, Department of Obstetrics and Gynecology, The Prenatal Diagnosis and Medical Genetics Program, The Ontario Power Generation Building, 700 University Avenue, Room 3292 ... Uygur D, Kis S, Sener E, Gunce S, Semerci N 2004. ...