Papers by Lawrence Edemhanria
Natural products chemistry & research, Jun 21, 2018
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SAU Science-Tech Journal, Jul 28, 2016
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The greatest challenge facing the pharmacological use of phytochemicals is the fact that they are... more The greatest challenge facing the pharmacological use of phytochemicals is the fact that they are subject to modifications by the several processes they may be exposed to. Thus, pharmacological activities of the new compounds become a matter of scientific interest. Scientists are further faced with the challenge of not knowing the direction of research since the activity of some modified products can differ greatly from the primary compounds. In this study, in silico approach was used to determine the pharmacological and biochemical activity of ascorbic acid and its oxidation products. The probable activity (Pa) was set at equal to or greater than (≥) 0.900 and probable inactivity (Pi) was set at equal to or less than (≤) 0.03. The oxidation products of ascorbic acid were observed to have lesser antioxidant activity. Other possible pharmacological activities such as antidiabetic and respiratory analeptic were revealed. This approach could guide research on new compounds and their pr...
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Global Journal of Pure and Applied Sciences, 2020
The continued use of potassium bromate in some food and cosmetic products in Nigeria against regu... more The continued use of potassium bromate in some food and cosmetic products in Nigeria against regulatory provision has continually exposed Nigerians to its deleterious effect. The mechanism of bromate induced damage in the liver and kidney is through oxidative stress. Phytochemicals have antioxidant capacity and have gained research interest in the management of oxidative stress. In this study, the effect of the ethanol extract of Aframomum angustifolium seed on kidney and liver damage induced by exposure to an acute dose of potassium bromate was measured using appropriate biomarkers. Eighteen male Wistar rats, randomly divided into 3 groups were used for the study. Group I (normal control) received distilled H2O; Group II (positive control) received 400 mg/kgbw bromate once while Group III (test) received same acute dose as Group II but thereafter treated with an oral dose of ethanol extract (750 mg/kgbw) for 10days. Half the populations of each group were sacrificed on day 3 while ...
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Zenodo (CERN European Organization for Nuclear Research), Jun 29, 2022
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Natural Resources and Sustainable Development, 2020
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In recent times, research done on Carica papaya seeds has shown its nutritive and medicinal benef... more In recent times, research done on Carica papaya seeds has shown its nutritive and medicinal benefits without resort to possible side effect. However, studies have shown that the consumption of C. papaya seeds causes vascular contraction, infertility in female rats, reduced sperm counts, sperm cell degeneration and abortifacient properties. This study was designed to determine the enzyme assay level of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities in the serum of wistar rats fed with modified diet of C. papaya milled seeds to ascertain possible hepatic or myocardia defect. A total of 15 wistar rats were divided into two groups comprising of test (8) and control (7) respectively. The test group were fed with modified diet of edible black C. papaya seeds and the control group with grower’s marsh feed for a period of 9 weeks. The determination of aspartate aminotransferase activity showed the Mean ± SEM of aspartate aminotransferase activity in the serum...
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Natural Resources and Sustainable Development
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Drugs continue to play critical roles in the maintenance of normal body functions. This is the th... more Drugs continue to play critical roles in the maintenance of normal body functions. This is the thrust behind the ongoing search for the development of effective and cost-effective drugs. Conventionally, drug discovery processes have involved studies on natural products and chemical synthesis to yield therapeutic formulations with commercial application. This process develops at a tremendous cost for a long time. Over the past few decades, computer technology has been used in drug discovery. This has led to improved understanding of the quantitative relationship between molecular structure and biological activity. In addition, greater understanding of the complex biological processes provided by progress in bioinformatics and genomics also contributes to drug discovery by promoting goal validation and data integration. New generation software or tools are now available in computer-aided drug discovery and they have contributed to shortening the drug design and discovery cycles with d...
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Background: Medicinal plants, as rich sources of bioactive compounds with antiviral properties, a... more Background: Medicinal plants, as rich sources of bioactive compounds with antiviral properties, are now being explored for the development of drugs against SARS-CoV-2.Aims: Identification of promising compounds for the treatment of COVID-19 from natural products via molecular modelling against NSP9, including some other viral and host targets and evaluation of polypharmacological indications.Main methods: A manually curated library of 521 phytochemicals (from 19 medicinal plants) was virtually screened using Mcule server and binding interactions were studied using DS Visualiser. Docking thresholds were set based on the scores of standard controls and rigorous ADMET properties were used to finally get the potential inhibitors. Free binding energies of the docked complexes were calculated employing MM-GBSA method. MM-GBSA informed our choice for MD simulation studies performed against NSP9 to study the stability of the drug-receptor interaction. NSP9 structure comparison was also perf...
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Journal of World's Poultry Research
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Spices are rich in phytochemicals which are responsible for their observed antioxidant property. ... more Spices are rich in phytochemicals which are responsible for their observed antioxidant property. This potential can be affected by heat treatment when spices are used as food additives. This research studied the effect of heat treatment on the antioxidant capacity of aqueous and ethanol extracts of Aframomum angustifolium seeds. The antioxidant capacity was measured in vitro by evaluating the metal chelating activity (MCA), ferric reducing ability (FRA), hydroxyl radical (•OH) scavenging activity, nitric oxide (NO) scavenging activity and total antioxidant capacity (TAC) before and after heat treatment. The percentage metal chelating activity of the extracts before heating were comparable (p > 0.05) to that of ascorbic acid while the percentage metal chelating activity of the ethanol extract decreased significantly (p < 0.05) from 65.99% to 47.62% after heat treatment for 30 min. The percentage hydroxyl radical scavenging activity of the aqueous extract was unaffected (p > ...
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SAU Sci-Tech Journal, 2016
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The greatest challenge facing the pharmacological use of phytochemicals is the fact that they are... more The greatest challenge facing the pharmacological use of phytochemicals is the fact that they are subject to modifications by the several processes they may be exposed to. Thus, pharmacological activities of the new compounds become a matter of scientific interest. Scientists are further faced with the challenge of not knowing the direction of research since the activity of some modified products can differ greatly from the primary compounds. In this study, in silico approach was used to determine the pharmacological and biochemical activity of ascorbic acid and its oxidation products. The probable activity (Pa) was set at equal to or greater than (≥) 0.900 and probable inactivity (Pi) was set at equal to or less than (≤) 0.03. The oxidation products of ascorbic acid were observed to have lesser antioxidant activity. Other possible pharmacological activities such as antidiabetic and respiratory analeptic were revealed. This approach could guide research on new compounds and their processing induced modified products that will greatly enhance drug discovery and formulation of functional foods.
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The greatest challenge facing the pharmacological use of phytochemicals is the fact that they are... more The greatest challenge facing the pharmacological use of phytochemicals is the fact that they are subject to
modifications by the several processes they may be exposed to. Thus, pharmacological activities of the new
compounds become a matter of scientific interest. Scientists are further faced with the challenge of not
knowing the direction of research since the activity of some modified products can differ greatly from the
primary compounds. In this study, in silico approach was used to determine the pharmacological and
biochemical activity of ascorbic acid and its oxidation products. The probable activity (Pa) was set at equal to
or greater than (≥) 0.900 and probable inactivity (Pi) was set at equal to or less than (≤) 0.03. The oxidation
products of ascorbic acid were observed to have lesser antioxidant activity. Other possible pharmacological
activities such as antidiabetic and respiratory analeptic were revealed. This approach could guide research on
new compounds and their processing induced modified products that will greatly enhance drug discovery and
formulation of functional foods.
Bookmarks Related papers MentionsView impact
Spices are rich in phytochemicals which are responsible for their observed antioxidant property. ... more Spices are rich in phytochemicals which are responsible for their observed antioxidant property. This potential can be affected by heat treatment when spices are used as food additives. This research studied the effect of heat treatment on the antioxidant capacity of aqueous and ethanol extracts of Aframomum angustifolium seeds. The antioxidant capacity was measured in vitro by evaluating the metal chelating activity (MCA), ferric reducing ability (FRA), hydroxyl radical (•OH) scavenging activity, nitric oxide (NO) scavenging activity and total antioxidant capacity (TAC) before and after heat treatment. The percentage metal chelating activity of the extracts before heating were comparable (p > 0.05) to that of ascorbic acid while the percentage metal chelating activity of the ethanol extract decreased significantly (p < 0.05) from 65.99% to 47.62% after heat treatment for 30 min. The percentage hydroxyl radical scavenging activity of the aqueous extract was unaffected (p > 0.05) by heat treatment whereas the activity in ethanol extract decreased. The ferric reducing ability of the extracts decreased significantly after heat treatment while the NO scavenging activity increased with heat treatment. The total antioxidant capacity (TAC) of the extracts measured as ascorbic acid equivalents reduced but were not significantly affected by heat treatment. The results of this study suggest that the antioxidant potential of aqueous and ethanol extracts of A. angustifolium seeds is not totally lost by heat treatment.
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This study investigated the effect of air and sun drying methods on the antioxidant capacity of O... more This study investigated the effect of air and sun drying methods on the antioxidant capacity of Ocimum basilicum L. leaves. The total antioxidant capacity, nitric oxide scavenging activity, hydroxyl radical scavenging activity, metal chelating activity and ferric reducing power were evaluated using standard spectrophotometric methods against different concentrations (30 to 120μg/ml) of the plant extract and ascorbic acid as reference standard. There was no significant difference in the total antioxidant capacity estimated as ascorbic acid equivalent between the air and sun-dried extracts. A concentration dependent increase in antioxidant capacity was observed in the other assays. The air – dried extract had the highest percentage activity except in the metal chelating and ferric reducing power assays. Hydroxyl radical scavenging activity of the air-dried extract (86.21±1.19%) was significantly higher than ascorbic acid (85.69±0.90%) and the sun-dried extract (77.14±1.19%) at 120μg/ml. The result of this study suggests a better potential for air drying of basil leaves for use as spices, food additive and in traditional medicine.
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This study investigated the effect of air and sun drying methods on the antioxidant capacity of O... more This study investigated the effect of air and sun drying methods on the antioxidant capacity of Ocimum basilicum L. leaves. The total antioxidant capacity, nitric oxide scavenging activity, hydroxyl radical scavenging activity, metal chelating activity and ferric reducing power were evaluated using standard spectrophotometric methods against different concentrations (30 to 120µg/ml) of the plant extract and ascorbic acid as reference standard. There was no significant difference in the total antioxidant capacity estimated as ascorbic acid equivalent between the air and sun-dried extracts. A concentration dependent increase in antioxidant capacity was observed in the other assays. The air – dried extract had the highest percentage activity except in the metal chelating and ferric reducing power assays. Hydroxyl radical scavenging activity of the air-dried extract (86.21±1.19%) was significantly higher than ascorbic acid (85.69±0.90%) and the sundried extract (77.14±1.19%) at 120µg/ml. The result of this study suggests a better potential for air drying of basil leaves for use as spices, food additive and in traditional medicine.
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Papers by Lawrence Edemhanria
modifications by the several processes they may be exposed to. Thus, pharmacological activities of the new
compounds become a matter of scientific interest. Scientists are further faced with the challenge of not
knowing the direction of research since the activity of some modified products can differ greatly from the
primary compounds. In this study, in silico approach was used to determine the pharmacological and
biochemical activity of ascorbic acid and its oxidation products. The probable activity (Pa) was set at equal to
or greater than (≥) 0.900 and probable inactivity (Pi) was set at equal to or less than (≤) 0.03. The oxidation
products of ascorbic acid were observed to have lesser antioxidant activity. Other possible pharmacological
activities such as antidiabetic and respiratory analeptic were revealed. This approach could guide research on
new compounds and their processing induced modified products that will greatly enhance drug discovery and
formulation of functional foods.
modifications by the several processes they may be exposed to. Thus, pharmacological activities of the new
compounds become a matter of scientific interest. Scientists are further faced with the challenge of not
knowing the direction of research since the activity of some modified products can differ greatly from the
primary compounds. In this study, in silico approach was used to determine the pharmacological and
biochemical activity of ascorbic acid and its oxidation products. The probable activity (Pa) was set at equal to
or greater than (≥) 0.900 and probable inactivity (Pi) was set at equal to or less than (≤) 0.03. The oxidation
products of ascorbic acid were observed to have lesser antioxidant activity. Other possible pharmacological
activities such as antidiabetic and respiratory analeptic were revealed. This approach could guide research on
new compounds and their processing induced modified products that will greatly enhance drug discovery and
formulation of functional foods.