Robert U Weiss

Pseudoangiomatous Stromal Hyperplasia (PASH) is a rare, benign proliferative condition of the breast stroma that can mimic more serious vascular lesions. Accurate diagnosis is critical to avoid unnecessary aggressive treatments. This case report highlights the clinical presentation, differential diagnosis, and the importance of detailed immunohistochemistry (IHC) studies in differentiating PASH from vascular lesions.

Gastrointestinal clear cell sarcoma (GICCS) is a rare and aggressive tumor that primarily affects the digestive system. When comparing soft parts' conventional clear cell sarcoma (CCS) to GICCS, there have been notably fewer instances of CCS emerging in the gastrointestinal tract. We describe a case of a 28-year-old man who presented with a large abdominal mass and liver metastasis. Diagnosing this case was initially difficult and challenging, but with the appropriate application of immunohistochemistry (IHC) and molecular studies, the correct diagnosis of GICCS was rendered. Literature review shows that other terms are used to describe GICCS, including clear cell sarcoma-like tumor of the gastrointestinal tract (CCSLGT), gastrointestinal neuroectodermal tumor (GNET), and gastrointestinal clear cell sarcoma/gastrointestinal neuroectodermal tumor GICCS/GNET. It is frequently difficult to determine if cases reported represent one or the other of these tumors due to their similarities, and it has been debated whether they could represent variations of the same entity, which we believe is the case. In this report, we will refer to gastrointestinal clear cell sarcoma as "CCSLGT," distinct from conventional clear cell sarcoma in other body sites. We discuss and clarify the nomenclatures used to describe this type of sarcoma. We also present the unique presentation, diagnostic evaluation, and treatment approach of a patient diagnosed with gastrointestinal clear cell sarcoma. Through a review of the literature, this report highlights the challenges in diagnosing this rare tumor and the importance of considering it in the differential diagnosis of gastrointestinal malignancies.