In this Review, Oh and Voigt explore the major characteristics and functions of the skin microbiome, and they highlight potential therapeutic targets in the skin microbiome and ongoing progress in the development of skin microbiome-based therapeutics.

In this Review, Warner, Barczak, Gutierrez and Mizrahi explore essential aspects of Mycobacterium tuberculosis physiology and biology, present recent advances related to its pathogenesis, metabolism and immune evasion mechanisms, and propose future directions for research.

Metal ions are required for all cells, and their homeostasis relies on ancient mechanisms that facilitate their import, distribution and storage. In this Review, Helmann discusses the key chemical concepts underlying microbial metal physiology and highlights several exemplary microbial systems.

This paper reports week 96 efficacy and safety findings from a multicentre, open-label phase IIIb trial of intramuscular cabotegravir and rilpivirine in adults living with HIV from Uganda, Kenya and South Africa.

This Genome Watch discusses recent advances in genomic epidemiology that enable the reconstruction of transmission events, with greater resolution and across more complex settings at scale.

This study identifies multiple low-density lipoprotein receptor family members, including LRP4, LRP1 and VLDLR, as entry receptors for yellow fever virus.

This study shows that sialokinin, which is a vasodilatory peptide that is expressed in the saliva of female Aedes aegypti, modulates immune responses and mitigates inflammation during chikungunya virus infection in mice.

This study assessed the ability of a replicating RNA vaccine expressing H5 haemagglutinin to protect cynomolgus macaques from lethal challenge with a clade 2.3.4.4b highly pathogenic avian influenza A H5N1 virus.

This study combines high-throughput RNA sequencing analysis of Mycobacterium tuberculosis clinical isolates with global population genomics to link diversity in gene expression with variants in genes encoding regulators.