Abstract
We report the emergence of five carbapenem-resistant K1 hypervirulent Klebsiella pneumoniae (hvKP) strains which caused fatal infections in hospital patients in Zhejiang Province, China, upon entry through surgical wounds. Genotyping results revealed the existence of three genetically related strains which exhibited a new sequence type, ST1797, and revealed that all strains harbored the magA and wcaG virulence genes and a plasmid-borne bla(KPC-2) gene. These findings indicate that K1 hvKP is simultaneously hypervirulent, multidrug resistant, and transmissible.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Carbapenems / pharmacology
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Carbohydrate Epimerases / genetics
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Carbohydrate Epimerases / metabolism
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China
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Female
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Genotype
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Humans
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Klebsiella Infections / drug therapy
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Klebsiella Infections / microbiology
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Klebsiella Infections / mortality
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Klebsiella Infections / pathology*
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Klebsiella pneumoniae / drug effects
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Klebsiella pneumoniae / genetics*
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Klebsiella pneumoniae / isolation & purification
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Klebsiella pneumoniae / pathogenicity*
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Male
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Middle Aged
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Multilocus Sequence Typing
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Plasmids / chemistry
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Plasmids / metabolism
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Serogroup
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Survival Analysis
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Virulence
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beta-Lactam Resistance / genetics*
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Carbapenems
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MagA protein, Klebsiella pneumoniae
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beta-Lactamases
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beta-lactamase KPC-2, Klebsiella pneumoniae
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Carbohydrate Epimerases