Abstract
The National Cancer Institute of the United States recently announced a major new initiative in understanding the genomes or, more broadly, the molecular phenotypes of exceptional responders. What can we expect to learn from exceptional responders? What are the potential benefits, and how do we approach studying them?
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References
Avicenna The Canon of Medicine (Persia, 1025).
Willyard, C. 'Basket studies' will hold intricate data for cancer drug approvals. Nature Med. 19, 655–655 (2013).
Stewart, D. J. & Kurzrock, R. Fool's gold, lost treasures, and the randomized clinical trial. BMC Cancer 13, 193 (2013).
Chou, A. et al. Clinical and molecular characterization of HER2 amplified-pancreatic cancer. Genome Med. 5, 78 (2013).
Iyer, G. et al. Genome sequencing identifies a basis for everolimus sensitivity. Science 338, 221 (2012).
Chang, K. et al. The Cancer Genome Atlas Pan-Cancer analysis project. Nature Genet. 45, 1113–1120 (2013).
Riley, W. T., Glasgow, R. E., Etheredge, L. & Abernethy, A. P. Rapid, responsive, relevant (R3) research: a call for a rapid learning health research enterprise. Clin. Transl. Med. 2, 10 (2013).
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Chang, D., Grimmond, S., Evans, T. et al. Mining the genomes of exceptional responders. Nat Rev Cancer 14, 291–292 (2014). https://doi.org/10.1038/nrc3723
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DOI: https://doi.org/10.1038/nrc3723
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