[go: up one dir, main page]

About: TET enzymes

An Entity of Type: Thing, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

The TET enzymes are a family of ten-eleven translocation (TET) methylcytosine dioxygenases. They are instrumental in DNA demethylation. 5-Methylcytosine (see first Figure) is a methylated form of the DNA base cytosine (C) that often regulates gene transcription and has several other functions in the genome. TET enzymes have central roles in DNA demethylation required during embryogenesis, gametogenesis, memory, learning, addiction and pain perception.

thumbnail
Property Value
dbo:abstract
  • The TET enzymes are a family of ten-eleven translocation (TET) methylcytosine dioxygenases. They are instrumental in DNA demethylation. 5-Methylcytosine (see first Figure) is a methylated form of the DNA base cytosine (C) that often regulates gene transcription and has several other functions in the genome. Demethylation by TET enzymes (see second Figure), can alter the regulation of transcription. The TET enzymes catalyze the hydroxylation of DNA 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), and can further catalyse oxidation of 5hmC to 5-formylcytosine (5fC) and then to 5-carboxycytosine (5caC). 5fC and 5caC can be removed from the DNA base sequence by base excision repair and replaced by cytosine in the base sequence. TET enzymes have central roles in DNA demethylation required during embryogenesis, gametogenesis, memory, learning, addiction and pain perception. (en)
  • TET 효소(영어: TET enzyme)는 10-11 전위(ten-eleven translocation, TET) 메틸사이토신 이산소화효소의 패밀리이다. TET 효소는 에서 중요한 역할을 한다. 5-메틸사이토신은 종종 유전자 전사를 조절하고 게놈에서 몇 가지 다른 기능을 갖는 DNA의 염기인 사이토신(C)의 메틸화된 형태이다. (ko)
dbo:thumbnail
dbo:wikiPageID
  • 64080717 (xsd:integer)
dbo:wikiPageLength
  • 31260 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 1094115276 (xsd:integer)
dbo:wikiPageWikiLink
dbp:wikiPageUsesTemplate
dcterms:subject
rdfs:comment
  • TET 효소(영어: TET enzyme)는 10-11 전위(ten-eleven translocation, TET) 메틸사이토신 이산소화효소의 패밀리이다. TET 효소는 에서 중요한 역할을 한다. 5-메틸사이토신은 종종 유전자 전사를 조절하고 게놈에서 몇 가지 다른 기능을 갖는 DNA의 염기인 사이토신(C)의 메틸화된 형태이다. (ko)
  • The TET enzymes are a family of ten-eleven translocation (TET) methylcytosine dioxygenases. They are instrumental in DNA demethylation. 5-Methylcytosine (see first Figure) is a methylated form of the DNA base cytosine (C) that often regulates gene transcription and has several other functions in the genome. TET enzymes have central roles in DNA demethylation required during embryogenesis, gametogenesis, memory, learning, addiction and pain perception. (en)
rdfs:label
  • TET 효소 (ko)
  • TET enzymes (en)
owl:sameAs
prov:wasDerivedFrom
foaf:depiction
foaf:isPrimaryTopicOf
is dbo:wikiPageDisambiguates of
is dbo:wikiPageRedirects of
is dbo:wikiPageWikiLink of
is foaf:primaryTopic of
Powered by OpenLink Virtuoso    This material is Open Knowledge     W3C Semantic Web Technology     This material is Open Knowledge    Valid XHTML + RDFa
This content was extracted from Wikipedia and is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License