The forty-fifth edition of the Caribbean Series (Serie del Caribe) was held from February 2 through February 8 of 2003 at Roberto Clemente Stadium in Carolina, Puerto Rico. It featured the champion baseball teams of the Dominican Republic, Águilas Cibaeñas; Mexico, Cañeros de Los Mochis, and Puerto Rico, Indios de Mayagüez. This time Venezuela did not participate in the tournament due to a national general strike, being replaced by the second place team from Puerto Rico, the Criollos de Caguas. The format consisted of 12 games, each team facing the other teams twice.