凝溶胶蛋白：修订间差异
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{{Infobox protein family |
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| Symbol = Gelsolin |
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| Name = Gelsolin |
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| image = PDB 1pd0 EBI.jpg |
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| width = |
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| caption = crystal structure of the copii coat subunit, sec24, complexed with a peptide from the snare protein sed5 (yeast syntaxin-5) |
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| Pfam = PF00626 |
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| Pfam_clan = CL0092 |
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| InterPro = IPR007123 |
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| SMART = |
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| PROSITE = |
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| MEROPS = |
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| SCOP = 1vil |
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| TCDB = |
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| OPM family = |
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| OPM protein = |
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| CAZy = |
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| CDD = |
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}} |
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{{PBB|geneid=2934}} |
{{PBB|geneid=2934}} |
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'''凝溶胶蛋白'''（{{lang-en|Gelsolin}}）是一种[[肌动蛋白]]结合蛋白，是肌动蛋白丝装配和解聚调节的关键。凝溶胶蛋白是[[肌动蛋白结合蛋白]]中凝溶胶蛋白/{{le|绒毛蛋白|villin}}超家族的重要成员<ref name="Sun">{{cite journal | author = Sun HQ, Yamamoto M, Mejillano M, Yin HL | title = Gelsolin, a multifunctional actin regulatory protein | journal = J. Biol. Chem. | volume = 274 | issue = 47 | pages = 33179–82 |date=November 1999 | pmid = 10559185 | doi = 10.1074/jbc.274.47.33179 }}</ref>。凝溶胶蛋白表达于细胞内（在[[细胞质基质]]和[[线粒体]]）以及细胞外（[[血浆]]）<ref name="Koya">{{cite journal | author = Koya RC, Fujita H, Shimizu S, Ohtsu M, Takimoto M, Tsujimoto Y, Kuzumaki N | title = Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release | journal = J. Biol. Chem. | volume = 275 | issue = 20 | pages = 15343–9 |date=May 2000 | pmid = 10809769 | doi = 10.1074/jbc.275.20.15343 }}</ref>。 |
'''凝溶胶蛋白'''（{{lang-en|Gelsolin}}）是一种[[肌动蛋白]]结合蛋白，是肌动蛋白丝装配和解聚调节的关键。凝溶胶蛋白是[[肌动蛋白结合蛋白]]中凝溶胶蛋白/{{le|绒毛蛋白|villin}}超家族的重要成员<ref name="Sun">{{cite journal | author = Sun HQ, Yamamoto M, Mejillano M, Yin HL | title = Gelsolin, a multifunctional actin regulatory protein | journal = J. Biol. Chem. | volume = 274 | issue = 47 | pages = 33179–82 |date=November 1999 | pmid = 10559185 | doi = 10.1074/jbc.274.47.33179 }}</ref>。凝溶胶蛋白表达于细胞内（在[[细胞质基质]]和[[线粒体]]）以及细胞外（[[血浆]]）<ref name="Koya">{{cite journal | author = Koya RC, Fujita H, Shimizu S, Ohtsu M, Takimoto M, Tsujimoto Y, Kuzumaki N | title = Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release | journal = J. Biol. Chem. | volume = 275 | issue = 20 | pages = 15343–9 |date=May 2000 | pmid = 10809769 | doi = 10.1074/jbc.275.20.15343 }}</ref>。 |
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2021年10月3日 (日) 09:24的最新版本
凝溶胶蛋白（英語：Gelsolin）是一种肌动蛋白结合蛋白，是肌动蛋白丝装配和解聚调节的关键。凝溶胶蛋白是肌动蛋白结合蛋白中凝溶胶蛋白/绒毛蛋白超家族的重要成员[1]。凝溶胶蛋白表达于细胞内（在细胞质基质和线粒体）以及细胞外（血浆）[2]。
结构
[编辑]凝溶胶蛋白是一个82千道尔顿的蛋白质，具有六个同源亚结构域，称为S1-S6。每个亚结构域都包含有五片β折叠，旁边缀有两个α螺旋，一个垂直，另一个平行于β折叠片。其N端（S1-S3）和C端（S4-S6）各自组成了一个额外的β折叠[3]。
参考文献
[编辑]- ^ Sun HQ, Yamamoto M, Mejillano M, Yin HL. Gelsolin, a multifunctional actin regulatory protein. J. Biol. Chem. November 1999, 274 (47): 33179–82. PMID 10559185. doi:10.1074/jbc.274.47.33179.
- ^ Koya RC, Fujita H, Shimizu S, Ohtsu M, Takimoto M, Tsujimoto Y, Kuzumaki N. Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release. J. Biol. Chem. May 2000, 275 (20): 15343–9. PMID 10809769. doi:10.1074/jbc.275.20.15343.
- ^ Kiselar JG, Janmey PA, Almo SC, Chance MR. Visualizing the Ca2+-dependent activation of gelsolin by using synchrotron footprinting. Proc. Natl. Acad. Sci. U.S.A. April 2003, 100 (7): 3942–7. PMC 153027
. PMID 12655044. doi:10.1073/pnas.0736004100.