Prostate cancer is the second most common cancer among men and the leading cause of death after l... more Prostate cancer is the second most common cancer among men and the leading cause of death after lung cancer. Development of hormone-refractory disease is a crucial step for prostate cancer progression for which an effective treatment option is currently unavailable. Therefore, there is a need for new agents that can efficiently target cancer cells, decrease tumor growth, and thereby extend the survival of patients in late-stage castration-resistant prostate cancer. In the current study, a novel heterodinuclear copper(II)Mn(II) Schiff base complex combined with P85 was used to evaluate anticancer activity against prostate cancer in vitro and in vivo. Cell proliferation and cytotoxicity were evaluated by cell viability, gene, and protein expression assays in vitro. Results showed that the heterodinuclear copper(II)Mn(II) complex-P85 combination decreased cell proliferation by upregulating the apoptotic gene expressions and blocking the cell proliferation-related pathways. Tramp-C1-inj...
ABSTRACT Objectives: To investigate the probable tissue damage after the application of static ul... more ABSTRACT Objectives: To investigate the probable tissue damage after the application of static ultrasound in the intensities, durations, and session numbers identical to the originally defined high-power pain threshold ultrasound technique that has been shown to be effective in the treatment of myofascial trigger points. Methods: Twenty-four male Wistar-albino rats were used in a controlled single-blinded experimental model. The animals were assigned into three groups and underwent the static ultrasound applications in intensities ranging from 0.5 watt/cm2 to 1.5 watt/cm2. Muscle, peripheral nerve, spinal cord, and bone tissue were pathologically assessed for the signs of any possible damage. Blood samples were analyzed for abnormal creatine kinase level. Results: Creatine kinase levels were normal in all the cases. Pathological analyses of the tissue samples taken from the nerve, muscle, spinal cord, and bone tissues revealed no abnormal findings. Conclusion: The static ultrasound technique applied in identical intensities and durations to the high-power pain threshold ultrasound technique used in the treatment of myofascial trigger points in an original experimental model did not lead to tissue damage.
Pigmented Bowen's disease is a rare subtype of in situ squamous cell carcinoma of the skin and mu... more Pigmented Bowen's disease is a rare subtype of in situ squamous cell carcinoma of the skin and mucosa, with a potential risk of invasion and metastasis. It is universally accepted that human papillomavirus (HPV) is the cause of genital Bowen's disease. Herein we report an unusual case of pigmented Bowen's disease of the genital area that clinically simulated malignant melanoma. Accurate diagnosis could only be established after histological examination. Polymerase chain reaction (PCR) analysis showed that the lesion harbored HPV 16 DNA. Although pigmented Bowen's disease is rare, it should be considered in the differential diagnosis of all pigmented lesions of the genitalia. This case report highlights the necessity of biopsy and histopathological examination for every suspicious cutaneous lesion.
To determine the cytologic features that are most helpful in characterizing significant glandular... more To determine the cytologic features that are most helpful in characterizing significant glandular lesions of the cervix observed on the ThinPrep (TP) Pap test (Cytyc Corp., Boxborough, Massachusetts, U.S.A.) and to compare these features with those published for conventional smears. Thirty-nine TP preparations with cytologic evidence of glandular lesions of the cervix and histologic and/or clinical correlation were studied. These lesions included (1) 11 cases of benign/reactive conditions; (2) 10 cases of adenocarcinoma in situ (AIS), of which 1 had both AIS and carcinoma in situ; (3) 1 case of invasive adenocarcinoma; (4) 15 cases of squamous intraepithelial lesions and squamous cell carcinoma, including 4 with glandular involvement, and (5) 2 cases of adenosquamous cell carcinoma. These cases were reviewed by the first author without knowledge of the histologic diagnosis. Twenty-five previously published cytologic criteria were used to evaluate glandular cells on TP slides. Statistical analysis was performed using Fisher's exact test to determine the significance of the features studied. All glandular lesions had cytologic features on TP similar to those previously described on conventional smears. However, TP slides demonstrated enhanced nuclear features but less-preserved architectural patterns. Reactive lesions showed minimal overlapping without hyperchromasia or mitotic figures and with normal nuclear/cytoplasmic ratios. AIS and invasive adenocarcinoma cases had similar features. Increased cellularity and overcrowding were prominent, whereas feathering, rosettes and cell strips were present but subtle. Glandular lesions of the cervix on TP slides shared many of the characteristic features reported for conventional smears. However, nuclear details were more pronounced in TP slides, while architectural patterns, although present, were relatively subtle.
Turk Pediatri Arsivi-turkish Archives of Pediatrics, 2006
Objective: The objective of this study is to analyse the patients with eye mass who were admitted... more Objective: The objective of this study is to analyse the patients with eye mass who were admitted to our clinic in a period of 20 years to classify both benign and malignant orbital or ocular tumors and to inform the pediatricians about the outcome of our analysis Material and Method: The records of 315 patients applied or referred to our pediatric hematology oncology department with eye mass between January1985 and December 2004 were reviewed The sex distribution the involvement site and the age at dignosis were analysed Results: 156 49 5 patients were males while 159 50 5 were females 151 of the masses involved the left eye 47 9 while 147 of them 46 7 were at the right side and 17 5 4 involved both eyes The age at diagnosis range ed between 1 and 192 months The median age at diagnosis was 25 months 282 89 6 of the cases had orbital tumors 22 6 9 cases had ocular surface tumors and 11 3 5 had intraocular tumors Conclusions: Pediatricians should notice the signs and symptoms of pediatric ocular and orbital tumors while examining their patients We would like to emphasize the importance of noticing the signs and symptoms of pediatric ocular and orbital tumors and vitality of referring patients to ophtalmologist in time Key words: child eye mass orbital
Turk Pediatri Arsivi-turkish Archives of Pediatrics, 2005
Amaç: Bu çalışmada klinigimizde tek bir merkezde tedavi görmüş osteosarkom olguları geriye dönük ... more Amaç: Bu çalışmada klinigimizde tek bir merkezde tedavi görmüş osteosarkom olguları geriye dönük olarak incelenmiştir. Gereç ve Yöntem: Kasım 1990-2004 yılları arasında COSS protokolüne göre tedavi gören 27 osteosarkomlu hastamızın sonuçları verilmiştir. Hastalarımızın ...
Purpose: The objective of this study is to evaluate prognostic implications of clinical, histopat... more Purpose: The objective of this study is to evaluate prognostic implications of clinical, histopathological features and immuhistochemical expressions of p53, ERBB2, c-Kit and Bcl-2 in pediatric medulloblastoma. Materials and Methods: A total of 29 pediatric medulloblastoma cases were evaluated for prognostic association of demographic, clinical, histopathological features and immunohistochemical expressions of p53, ERBB2, c-Kit and Bcl-2. Results: Median age at diagnosis was 69 months (21-122 months). Median duration of follow-up was 54 months (2-209 months). Fourteen of samples were diagnosed as classical (48%), thirteen cases as nodular/desmoplastic (45%) and two cases as anaplastic (7%) subtype. Staining for c-Kit, Bcl-2, p53 and ERBB2 was positive in 28, 10, 9 and 2 samples, respectively. Overall (OS) and event-free survival (EFS) were 62 % and 52%, respectively. Bcl-2 expression was found to be significantly increased in nodular/desmoplastic subtype. None of the clinical, histopathological and immunohistochemical features were related to survival. Conclusion: This study reflects the earliest periods of current multimodal treatment protocols of medulloblastoma with similar survival rates in literature. Although none of the proposed factors have been associated with survival, future studies combining molecular and immunohistochemical methods would be more convenient for detecting new prognostic criteria in pediatric medulloblastoma.
Prostate cancer is the second most common cancer among men and the leading cause of death after l... more Prostate cancer is the second most common cancer among men and the leading cause of death after lung cancer. Development of hormone-refractory disease is a crucial step for prostate cancer progression for which an effective treatment option is currently unavailable. Therefore, there is a need for new agents that can efficiently target cancer cells, decrease tumor growth, and thereby extend the survival of patients in late-stage castration-resistant prostate cancer. In the current study, a novel heterodinuclear copper(II)Mn(II) Schiff base complex combined with P85 was used to evaluate anticancer activity against prostate cancer in vitro and in vivo. Cell proliferation and cytotoxicity were evaluated by cell viability, gene, and protein expression assays in vitro. Results showed that the heterodinuclear copper(II)Mn(II) complex-P85 combination decreased cell proliferation by upregulating the apoptotic gene expressions and blocking the cell proliferation-related pathways. Tramp-C1-inj...
ABSTRACT Objectives: To investigate the probable tissue damage after the application of static ul... more ABSTRACT Objectives: To investigate the probable tissue damage after the application of static ultrasound in the intensities, durations, and session numbers identical to the originally defined high-power pain threshold ultrasound technique that has been shown to be effective in the treatment of myofascial trigger points. Methods: Twenty-four male Wistar-albino rats were used in a controlled single-blinded experimental model. The animals were assigned into three groups and underwent the static ultrasound applications in intensities ranging from 0.5 watt/cm2 to 1.5 watt/cm2. Muscle, peripheral nerve, spinal cord, and bone tissue were pathologically assessed for the signs of any possible damage. Blood samples were analyzed for abnormal creatine kinase level. Results: Creatine kinase levels were normal in all the cases. Pathological analyses of the tissue samples taken from the nerve, muscle, spinal cord, and bone tissues revealed no abnormal findings. Conclusion: The static ultrasound technique applied in identical intensities and durations to the high-power pain threshold ultrasound technique used in the treatment of myofascial trigger points in an original experimental model did not lead to tissue damage.
Pigmented Bowen's disease is a rare subtype of in situ squamous cell carcinoma of the skin and mu... more Pigmented Bowen's disease is a rare subtype of in situ squamous cell carcinoma of the skin and mucosa, with a potential risk of invasion and metastasis. It is universally accepted that human papillomavirus (HPV) is the cause of genital Bowen's disease. Herein we report an unusual case of pigmented Bowen's disease of the genital area that clinically simulated malignant melanoma. Accurate diagnosis could only be established after histological examination. Polymerase chain reaction (PCR) analysis showed that the lesion harbored HPV 16 DNA. Although pigmented Bowen's disease is rare, it should be considered in the differential diagnosis of all pigmented lesions of the genitalia. This case report highlights the necessity of biopsy and histopathological examination for every suspicious cutaneous lesion.
To determine the cytologic features that are most helpful in characterizing significant glandular... more To determine the cytologic features that are most helpful in characterizing significant glandular lesions of the cervix observed on the ThinPrep (TP) Pap test (Cytyc Corp., Boxborough, Massachusetts, U.S.A.) and to compare these features with those published for conventional smears. Thirty-nine TP preparations with cytologic evidence of glandular lesions of the cervix and histologic and/or clinical correlation were studied. These lesions included (1) 11 cases of benign/reactive conditions; (2) 10 cases of adenocarcinoma in situ (AIS), of which 1 had both AIS and carcinoma in situ; (3) 1 case of invasive adenocarcinoma; (4) 15 cases of squamous intraepithelial lesions and squamous cell carcinoma, including 4 with glandular involvement, and (5) 2 cases of adenosquamous cell carcinoma. These cases were reviewed by the first author without knowledge of the histologic diagnosis. Twenty-five previously published cytologic criteria were used to evaluate glandular cells on TP slides. Statistical analysis was performed using Fisher's exact test to determine the significance of the features studied. All glandular lesions had cytologic features on TP similar to those previously described on conventional smears. However, TP slides demonstrated enhanced nuclear features but less-preserved architectural patterns. Reactive lesions showed minimal overlapping without hyperchromasia or mitotic figures and with normal nuclear/cytoplasmic ratios. AIS and invasive adenocarcinoma cases had similar features. Increased cellularity and overcrowding were prominent, whereas feathering, rosettes and cell strips were present but subtle. Glandular lesions of the cervix on TP slides shared many of the characteristic features reported for conventional smears. However, nuclear details were more pronounced in TP slides, while architectural patterns, although present, were relatively subtle.
Turk Pediatri Arsivi-turkish Archives of Pediatrics, 2006
Objective: The objective of this study is to analyse the patients with eye mass who were admitted... more Objective: The objective of this study is to analyse the patients with eye mass who were admitted to our clinic in a period of 20 years to classify both benign and malignant orbital or ocular tumors and to inform the pediatricians about the outcome of our analysis Material and Method: The records of 315 patients applied or referred to our pediatric hematology oncology department with eye mass between January1985 and December 2004 were reviewed The sex distribution the involvement site and the age at dignosis were analysed Results: 156 49 5 patients were males while 159 50 5 were females 151 of the masses involved the left eye 47 9 while 147 of them 46 7 were at the right side and 17 5 4 involved both eyes The age at diagnosis range ed between 1 and 192 months The median age at diagnosis was 25 months 282 89 6 of the cases had orbital tumors 22 6 9 cases had ocular surface tumors and 11 3 5 had intraocular tumors Conclusions: Pediatricians should notice the signs and symptoms of pediatric ocular and orbital tumors while examining their patients We would like to emphasize the importance of noticing the signs and symptoms of pediatric ocular and orbital tumors and vitality of referring patients to ophtalmologist in time Key words: child eye mass orbital
Turk Pediatri Arsivi-turkish Archives of Pediatrics, 2005
Amaç: Bu çalışmada klinigimizde tek bir merkezde tedavi görmüş osteosarkom olguları geriye dönük ... more Amaç: Bu çalışmada klinigimizde tek bir merkezde tedavi görmüş osteosarkom olguları geriye dönük olarak incelenmiştir. Gereç ve Yöntem: Kasım 1990-2004 yılları arasında COSS protokolüne göre tedavi gören 27 osteosarkomlu hastamızın sonuçları verilmiştir. Hastalarımızın ...
Purpose: The objective of this study is to evaluate prognostic implications of clinical, histopat... more Purpose: The objective of this study is to evaluate prognostic implications of clinical, histopathological features and immuhistochemical expressions of p53, ERBB2, c-Kit and Bcl-2 in pediatric medulloblastoma. Materials and Methods: A total of 29 pediatric medulloblastoma cases were evaluated for prognostic association of demographic, clinical, histopathological features and immunohistochemical expressions of p53, ERBB2, c-Kit and Bcl-2. Results: Median age at diagnosis was 69 months (21-122 months). Median duration of follow-up was 54 months (2-209 months). Fourteen of samples were diagnosed as classical (48%), thirteen cases as nodular/desmoplastic (45%) and two cases as anaplastic (7%) subtype. Staining for c-Kit, Bcl-2, p53 and ERBB2 was positive in 28, 10, 9 and 2 samples, respectively. Overall (OS) and event-free survival (EFS) were 62 % and 52%, respectively. Bcl-2 expression was found to be significantly increased in nodular/desmoplastic subtype. None of the clinical, histopathological and immunohistochemical features were related to survival. Conclusion: This study reflects the earliest periods of current multimodal treatment protocols of medulloblastoma with similar survival rates in literature. Although none of the proposed factors have been associated with survival, future studies combining molecular and immunohistochemical methods would be more convenient for detecting new prognostic criteria in pediatric medulloblastoma.
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