calcitonin (Q315860)

Foundational Model of Anatomy

1 August 2019

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01258

Calcitonin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Calcitonin peptide-like family

1 reference

based on heuristic

inferred from protein domain or family

procalcitonin

0 references

calcitonin receptor activity

subject has role

reactant

1 reference

Gene Ontology release 2019-11-16

1 reference

Gene Ontology release 2019-11-16

calcitonin catabolic process

subject has role

reactant

1 reference

Gene Ontology release 2019-11-16

1 reference

Gene Ontology release 2022-07-01

mass

3,418.597793 dalton

1 reference

SCHEMBL268375 (English)

21 September 2016

chemical formula

C₁₅₁H₂₂₈N₄₀O₄₅S₃

1 reference

calcitonin receptor binding

SCHEMBL268375 (English)

21 September 2016

1 reference

13 November 2019

1 reference

13 November 2019

The deletion of 14 amino acids in the seventh transmembrane domain of a naturally occurring calcitonin receptor isoform alters ligand binding and selectively abolishes coupling to phospholipase C

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01258&geneProductId=UniProtKB:P01258

16 July 2018

Cloning and characterization of an abundant subtype of the human calcitonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01258&geneProductId=UniProtKB:P01258

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01258&geneProductId=UniProtKB:P01258

protein binding

1 reference

8 April 2019

The interaction between endogenous calcineurin and the plasma membrane calcium-dependent ATPase is isoform specific in breast cancer cells

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

identical protein binding

1 reference

8 April 2019

Identification of a novel 'aggregation-prone'/'amyloidogenic determinant' peptide in the sequence of the highly amyloidogenic human calcitonin

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

signaling receptor binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

calcitonin receptor binding

Cloning and characterization of an abundant subtype of the human calcitonin receptor

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

1 January 2018

The deletion of 14 amino acids in the seventh transmembrane domain of a naturally occurring calcitonin receptor isoform alters ligand binding and selectively abolishes coupling to phospholipase C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

calcitonin receptor binding

The deletion of 14 amino acids in the seventh transmembrane domain of a naturally occurring calcitonin receptor isoform alters ligand binding and selectively abolishes coupling to phospholipase C

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

8 April 2019

Cloning and characterization of an abundant subtype of the human calcitonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

cell component

cytoplasm

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

intracellular anatomical structure

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01258&geneProductId=UniProtKB:P01258

extracellular region

TAS

axon

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

terminal bouton

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

neuronal cell body

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

neuron projection

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

nucleus

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

extracellular space

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

1 January 2018

Reference range of serum calcitonin levels in humans: influence of calcitonin assays, sex, age, and cigarette smoking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

extracellular space

cellular response to nerve growth factor stimulus

biological process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

1 reference

8 April 2019

Cloning and characterization of an abundant subtype of the human calcitonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

negative regulation of smooth muscle contraction

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

regulation of heart contraction

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

monocyte chemotaxis

1 reference

8 April 2019

Expression and function of RANK in human monocyte chemotaxis

GOA

curator

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

negative regulation of blood pressure

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

positive regulation of cytosolic calcium ion concentration

1 reference

8 April 2019

Calcitonin promotes outgrowth of trophoblast cells on endometrial epithelial cells: involvement of calcium mobilization and protein kinase C activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

cellular response to tumor necrosis factor

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

human ageing

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

vasodilation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

cellular calcium ion homeostasis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

response to heat

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

negative regulation of nervous system process

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01258&geneProductId=UniProtKB:P01258

positive regulation of ossification

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01258&geneProductId=UniProtKB:P01258

activation of adenylate cyclase activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

regulation of heart rate

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01258&geneProductId=UniProtKB:P01258

detection of temperature stimulus involved in sensory perception of pain

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

negative regulation of ossification

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

response to pain

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

feeding behavior

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

inflammatory response

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

neuropeptide signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

negative regulation of transcription, DNA-templated

1 reference

8 April 2019

Calcitonin receptor regulation and responsiveness to calcitonin in human osteoclast-like cells prepared in vitro using receptor activator of nuclear factor-kappaB ligand and macrophage colony-stimulating factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

activation of protein kinase activity

1 reference

8 April 2019

Calcitonin promotes outgrowth of trophoblast cells on endometrial epithelial cells: involvement of calcium mobilization and protein kinase C activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

embryo implantation

1 reference

8 April 2019

Calcitonin promotes outgrowth of trophoblast cells on endometrial epithelial cells: involvement of calcium mobilization and protein kinase C activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

negative regulation of bone resorption

1 reference

8 April 2019

Regulation and enzymatic basis of bone resorption by human osteoclasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

1 reference

8 April 2019

adenylate cyclase-activating G protein-coupled receptor signaling pathway

TAS

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01258&geneProductId=UniProtKB:P01258

16 July 2018

Cloning and characterization of an abundant subtype of the human calcitonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01258&geneProductId=UniProtKB:P01258

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01258&geneProductId=UniProtKB:P01258

16 July 2018

adenylate cyclase-activating G protein-coupled receptor signaling pathway

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

1 January 2018

Cloning and characterization of an abundant subtype of the human calcitonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

1 January 2018

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

regulation of cytosolic calcium ion concentration

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

adenylate cyclase-activating G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

3 references

8 April 2019

8 April 2019

Cloning and characterization of an abundant subtype of the human calcitonin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01258

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

685

human atrial cardiomyocyte

17 August 2016

produced by

1 reference

Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia

subject has role

bone density conservation agents

1 reference

https://www.uniprot.org/uniprot/P01258#PRO_0000004051

Medical Subject Headings

15 March 2018

3004.39.25

0 references

exact match

0 references

has part(s)

Calcitonin, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01258

Calcitonin peptide-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01258

Commons category

Calcitonin

0 references

Identifiers

National Library of Spain ID

XX531780

subject named as

Calcitonina

2 references

Nuovo soggettario

https://thes.bncf.firenze.sbn.it/termine.php?id=51088

17 June 2021

Spain open data portal

Registros de autoridad de "Materia" de la Biblioteca Nacional de España (Spanish)

https://www.bne.es/media/datosgob/catalogo-autoridades/materia/materia-UTF8.zip

Bibliothèque nationale de France ID

21 July 2023

11964818b

subject named as

Calcitonine

1 reference

Nuovo soggettario

https://thes.bncf.firenze.sbn.it/termine.php?id=51088

17 June 2021

1 reference

National Library of Israel

Library of Congress authority ID

sh85018767

subject named as

Calcitonin

1 reference

Nuovo soggettario

https://thes.bncf.firenze.sbn.it/termine.php?id=51088

17 June 2021

kalcitocin

0 references

InChIKey

MKPOFZGVVSUXKS-JKQNMTHDSA-N

1 reference

SCHEMBL268375 (English)

21 September 2016

0 references

2 references

Salmon Calcitonin (English)

publication date

17 November 2015

Global Substance Registration System

15 February 2018

1 reference

(3S)-4-[[(1S)-2-[[(1S)-3-amino-1-[[(1S)-5-amino-1-[[(1S)-2-[[(1S)-2-[[(1S,2R)-1-[[(1S)-2-[(2S)-2-[[(1S)-4-amino-1-[[(1S,2R)-1-[[(1S)-2-[[(1S,2S)-1-[[2-[[(1S)-1-[[2-[[(1S)-2-[(2S)-2-carbamoylpyrrolidin (English)

21 September 2016

2 references