parathyroid hormone 1 receptor (Q21108487)

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mammalian protein found in Homo sapiens

seven transmembrane helix receptor
PTH1 receptor
PTH/PTHrP type I receptor
parathyroid hormone/parathyroid hormone-related protein receptor
PTH1R
parathyroid hormone receptor 1
parathyroid hormone/parathyroid hormone-related peptide receptor
PTH/PTHr receptor

Language	Label	Description	Also known as
English	parathyroid hormone 1 receptor	mammalian protein found in Homo sapiens	seven transmembrane helix receptor PTH1 receptor PTH/PTHrP type I receptor parathyroid hormone/parathyroid hormone-related protein receptor PTH1R parathyroid hormone receptor 1 parathyroid hormone/parathyroid hormone-related peptide receptor PTH/PTHr receptor

Statements

1 reference

13 November 2019

UniProt protein ID

GPCR family 2, extracellular hormone receptor domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q03431

GPCR, family 2, parathyroid hormone receptor

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q03431

G protein-coupled receptor

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

GPCR, family 2, extracellular hormone receptor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

GPCR, family 2-like

1 reference

based on heuristic

inferred from protein domain or family

GPCR, family 2, secretin-like, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

parathyroid hormone receptor activity

determination method or standard

5 references

27 March 2018

Human osteoclast-like cells are formed from peripheral blood mononuclear cells in a coculture with SaOS-2 cells transfected with the parathyroid hormone (PTH)/PTH-related protein receptor gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03431&geneProductId=UniProtKB:Q03431

determination method or standard

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03431&geneProductId=UniProtKB:Q03431

determination method or standard

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03431&geneProductId=UniProtKB:Q03431

determination method or standard

27 March 2018

Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03431&geneProductId=UniProtKB:Q03431

determination method or standard

27 March 2018

Cloning and functional expression of a human parathyroid hormone receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03431&geneProductId=UniProtKB:Q03431

determination method or standard

signal transducer activity

determination method or standard

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03431&geneProductId=UniProtKB:Q03431

determination method or standard

protein self-association

determination method or standard

1 reference

8 April 2019

Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

protein binding

determination method or standard

2 references

8 April 2019

Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

8 April 2019

β-catenin regulates parathyroid hormone/parathyroid hormone-related protein receptor signals and chondrocyte hypertrophy through binding to the intracellular C-terminal region of the receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

transmembrane signaling receptor activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

protein homodimerization activity

determination method or standard

1 reference

8 April 2019

Characterization of a PTH1R missense mutation responsible for Jansen type metaphyseal chondrodysplasia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

parathyroid hormone receptor activity

determination method or standard

6 references

8 April 2019

Human osteoclast-like cells are formed from peripheral blood mononuclear cells in a coculture with SaOS-2 cells transfected with the parathyroid hormone (PTH)/PTH-related protein receptor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

8 April 2019

Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

8 April 2019

Cloning and functional expression of a human parathyroid hormone receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

G protein-coupled peptide receptor activity

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

peptide hormone binding

determination method or standard

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

8 April 2019

Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

plasma membrane

determination method or standard

intracellular anatomical structure

determination method or standard

1 reference

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03431&geneProductId=UniProtKB:Q03431

determination method or standard

brush border membrane

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

integral component of plasma membrane

determination method or standard

3 references

8 April 2019

Novel, missense and loss-of-function mutations in the sodium/iodide symporter gene causing iodide transport defect in three Japanese patients

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

8 April 2019

Cloning and functional expression of a human parathyroid hormone receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

8 April 2019

Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

biological process

G protein-coupled receptor signaling pathway

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

8 April 2019

Novel, missense and loss-of-function mutations in the sodium/iodide symporter gene causing iodide transport defect in three Japanese patients

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

bone mineralization

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

chondrocyte differentiation

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

determination method or standard

positive regulation of cytosolic calcium ion concentration

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

determination method or standard

2 references

8 April 2019

Human osteoclast-like cells are formed from peripheral blood mononuclear cells in a coculture with SaOS-2 cells transfected with the parathyroid hormone (PTH)/PTH-related protein receptor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

cellular calcium ion homeostasis

determination method or standard

1 reference

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03431&geneProductId=UniProtKB:Q03431

determination method or standard

cell maturation

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

bone resorption

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

phospholipase C-activating G protein-coupled receptor signaling pathway

determination method or standard

2 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

8 April 2019

The parathyroid hormone 1 receptor directly binds to the FERM domain of ezrin, an interaction that supports apical receptor localization and signaling in LLC-PK1 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

cell surface receptor signaling pathway

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

positive regulation of cell population proliferation

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

osteoblast development

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

signal transduction

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

negative regulation of cell population proliferation

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

adenylate cyclase-activating G protein-coupled receptor signaling pathway

determination method or standard

4 references

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

8 April 2019

Cloning and functional expression of a human parathyroid hormone receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

8 April 2019

Characterization of a PTH1R missense mutation responsible for Jansen type metaphyseal chondrodysplasia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03431

determination method or standard

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

GPCR, family 2, extracellular hormone receptor domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q03431

GPCR, family 2, secretin-like, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q03431

GPCR, family 2-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q03431

Identifiers

MeSH descriptor ID

subject named as

Receptor, Parathyroid Hormone, Type 1

0 references

D12.776.543.750.695.650.100

0 references

D12.776.543.750.750.600.100

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000321999

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000321999

ENSP00000402723

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000402723

ENSP00000411424

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000411424

ENSP00000413774

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000413774

ENSP00000389811

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000389811

ENSP00000396176

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000396176

ENSP00000400977

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000400977

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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