CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy (Q58235013)

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Annemieke Th. den Boer

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Ellen I.H. van der Voort

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Ton N.M. Schumacher

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Cornelis J.M. Melief

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Rienk Offringa

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Rene E. M. Toes

T cell priming versus T cell tolerance induced by synthetic peptides

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language of work or name

English

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publication date

July 1999

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774-779

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cites work

1 reference

Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells

21 January 2018

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Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model

21 January 2018

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Peptide antigen treatment of naive and virus-immune mice: antigen-specific tolerance versus immunopathology

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Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction.

21 January 2018

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A fail-safe mechanism for maintaining self-tolerance

21 January 2018

1 reference

CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity

21 January 2018

1 reference

T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions

21 January 2018

1 reference

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

21 January 2018

1 reference

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

21 January 2018

1 reference

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

21 January 2018

1 reference

B cells directly tolerize CD8(+) T cells

21 January 2018

1 reference

Cytotoxic T lymphocytes raised against a subdominant epitope offered as a synthetic peptide eradicate human papillomavirus type 16-induced tumors

21 January 2018

1 reference

Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand.

21 January 2018

1 reference

In vivo induction of antigen-specific transplantation tolerance to Qa1a by exposure to alloantigen in the absence of T-cell help

21 January 2018

1 reference

Viral and bacterial infections interfere with peripheral tolerance induction and activate CD8+ T cells to cause immunopathology

21 January 2018

1 reference

The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation

21 January 2018

1 reference

The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching.

21 January 2018

1 reference

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene

21 January 2018

1 reference

Phenotypic analysis of antigen-specific T lymphocytes

21 January 2018

1 reference

Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity

21 January 2018

1 reference

7 January 2021

Inflammation activates self hsp60-specific T cells

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7 January 2021

Murine experimental autoimmune hepatitis: nonspecific inflammation due to adjuvant oil

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7 January 2021

Induction of cytotoxic T-cell response by optimal-length peptides does not require CD4+ T-cell help

1 reference

7 January 2021

Enhancement of T cell-independent immune responses in vivo by CD40 antibodies

1 reference

7 January 2021

Systemic T cell expansion during localized viral infection

1 reference

7 January 2021