Basic Medical Research Award. The ubiquitin system (Q48372080)

11 February 2018

title

Basic Medical Research Award. The ubiquitin system (English)

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11 February 2018

A Ciechanover

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A Hershko

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author name string

A Varshavsky

series ordinal

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11 February 2018

language of work or name

English

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publication date

1 October 2000

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11 February 2018

published in

Nature Medicine

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volume

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issue

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page(s)

1073-1081

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Control of enzyme levels in animal tissues

cites work

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Mechanisms of Intracellular Protein Breakdown

21 January 2018

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A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes

21 January 2018

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A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes

21 January 2018

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Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells

21 January 2018

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Isopeptide linkage between nonhistone and histone 2A polypeptides of chromosomal conjugate-protein A24

21 January 2018

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ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation

21 January 2018

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Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis

21 January 2018

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Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome

21 January 2018

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21 January 2018

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Lessons from the discovery of the ubiquitin system

21 January 2018

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A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

21 January 2018

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Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

21 January 2018

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Role of arginine-tRNA in protein degradation by the ubiquitin pathway

21 January 2018

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The N-end rule pathway of protein degradation

21 January 2018

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Role of the alpha-amino group of protein in ubiquitin-mediated protein breakdown

21 January 2018

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

21 January 2018

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Cyclin is degraded by the ubiquitin pathway

21 January 2018

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Degradation of nuclear oncoproteins by the ubiquitin system in vitro

21 January 2018

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Ubiquitin-mediated proteolysis: biological regulation via destruction

21 January 2018

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Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase

21 January 2018

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Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein

21 January 2018

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The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

21 January 2018

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The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme

21 January 2018

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The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme

21 January 2018

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The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis

21 January 2018

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In vivo half-life of a protein is a function of its amino-terminal residue

21 January 2018

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Ubiquitin fusion technique and its descendants

21 January 2018

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The N-end rule: functions, mysteries, uses

21 January 2018

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A proteolytic pathway that recognizes ubiquitin as a degradation signal

21 January 2018

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Degradation signals in the lysine-asparagine sequence space

21 January 2018

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21 January 2018

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Physical association of ubiquitin ligases and the 26S proteasome

21 January 2018

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cis-trans recognition and subunit-specific degradation of short-lived proteins

21 January 2018

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Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway

21 January 2018

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RGS4 is arginylated and degraded by the N-end rule pathway in vitro

21 January 2018

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The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor

21 January 2018

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Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway

21 January 2018

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Some characteristics of the alanine aminotransferase- and arginase-inactivating system of lysosomes

21 January 2018

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7 January 2021

Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates

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7 January 2021

Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85

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7 January 2021

Degradation of proteins with acetylated amino termini by the ubiquitin system

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7 January 2021

Identifiers

DOI

10.1038/80384

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11 February 2018

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11 February 2018