P-glycoprotein and multidrug resistance (Q41239416)

28 September 2017

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title

P-glycoprotein and multidrug resistance (English)

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28 September 2017

main subject

multiple drug resistance

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Gottesman MM

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28 September 2017

Pastan I

series ordinal

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28 September 2017

Ambudkar SV

series ordinal

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28 September 2017

language of work or name

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1 October 1996

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Current Opinion in Genetics & Development

28 September 2017

published in

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28 September 2017

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28 September 2017

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28 September 2017

page(s)

610-617

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p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

28 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Genetic analysis of the multidrug transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Involvement ofMDR1 P-glycoprotein in multifactorial resistance to methotrexate

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Multidrug resistance proteins and other drug transport-related resistance to natural product agents.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Transport properties of the multidrug resistance-associated protein (MRP) in human tumour cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

The role of the MDR protein in altered drug translocation across tumor cell membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Purification and reconstitution of functional human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Lower electrical membrane potential and altered pHi homeostasis in multidrug-resistant (MDR) cells: further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

The effect of ion channel blockers, immunosuppressive agents, and other drugs on the activity of the multi‐drug transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Reconstitution of Drug Transport by Purified P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Is the multidrug transporter a flippase?

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Phosphatidylcholine translocase: a physiological role for the mdr2 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

P-glycoprotein Is Stably Inhibited by Vanadate-induced Trapping of Nucleotide at a Single Catalytic Site

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Both P-glycoprotein Nucleotide-binding Sites Are Catalytically Active

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

GTP-stimulated phosphorylation of P-glycoprotein in transporting vesicles from KB-V1 multidrug resistant cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

The catalytic cycle of P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Functional dissection of P-glycoprotein nucleotide-binding domains in chimeric and mutant proteins. Modulation of drug resistance profiles

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Functional reconstitution of P-glycoprotein reveals an apparent near stoichiometric drug transport to ATP hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Phorbol esters induce multidrug resistance in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Effects of phosphorylation of P-glycoprotein on multidrug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Phosphorylation by protein kinase C and cyclic AMP-dependent protein kinase of synthetic peptides derived from the linker region of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Bacterial expression of the linker region of human MDR1 P-glycoprotein and mutational analysis of phosphorylation sites

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

The Cystic Fibrosis Transmembrane Conductance Regulator

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Characterization of phosphorylation-defective mutants of human P-glycoprotein expressed in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Volume-activated chloride currents associated with the multidrug resistance P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Effects of hypotonic and hypoionic media on drug pumping by P-glycoprotein expressed in epithelial and nonepithelial cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

MDR1/P-glycoprotein function. I. Effect of hypotonicity and inhibitors on rhodamine 123 exclusion

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Volume-sensitive chloride channel activity does not depend on endogenous P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

The multidrug resistance (mdr1) gene product functions as an ATP channel

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Failure of the cystic fibrosis transmembrane conductance regulator to conduct ATP.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Biochemistry of multidrug resistance mediated by the multidrug transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

What have we learnt thus far from mice with disrupted P-glycoprotein genes?

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https://api.crossref.org/works/10.1016%2FS0959-437X%2896%2980091-8

7 January 2021

10.1016/S0959-437X(96)80091-8

Identifiers

DOI

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release_kuqidjbhpvdp7awzz2dg33vm34

28 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/kuqidjbhpvdp7awzz2dg33vm34

24 November 2022

mapped directly with Wikidata item

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