Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4. (Q36625495)

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scientific article published on August 1994

Language	Label	Description	Also known as
English	Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.	scientific article published on August 1994

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4. (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

author name string

Rhee SS

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Marsh JW

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

language of work or name

0 references

publication date

1 August 1994

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Journal of Virology

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

68

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

8

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

5156-5163

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals

1 reference

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30 September 2017

The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4.

1 reference

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The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages

1 reference

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Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

1 reference

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Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection

1 reference

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Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene

1 reference

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T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

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High-efficiency transformation of mammalian cells by plasmid DNA

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The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

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The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

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Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule

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Polymorphism of the 3' open reading frame of the virus associated with the acquired immune deficiency syndrome, human T-lymphotropic virus type III.

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Nucleotide sequence of the AIDS virus, LAV

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Lysosomal membrane dynamics: structure and interorganellar movement of a major lysosomal membrane glycoprotein

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30 September 2017

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1 reference

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Human immunodeficiency virus type 1 negative factor is a transcriptional silencer

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30 September 2017

Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor

1 reference

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30 September 2017

Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1.

1 reference

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Improved retroviral vectors for gene transfer and expression

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Internalization and recycling of CD4 transfected into HeLa and NIH3T3 cells

1 reference

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Lysosomal acid phosphatase is transported to lysosomes via the cell surface

1 reference

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30 September 2017

The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

1 reference

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30 September 2017

Complete nucleotide sequence of the AIDS virus, HTLV-III

1 reference

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30 September 2017

Molecular biology and function of CD4 and CD8

1 reference

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30 September 2017

Mutational analysis of the human immunodeficiency virus: the orf-B region down-regulates virus replication

1 reference

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Preassembled capsids of type D retroviruses contain a signal sufficient for targeting specifically to the plasma membrane

1 reference

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Intracellular interaction of human immunodeficiency virus type 1 (ARV-2) envelope glycoprotein gp160 with CD4 blocks the movement and maturation of CD4 to the plasma membrane

1 reference

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CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor

1 reference

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Expression and biochemical characterization of human immunodeficiency virus type 1 nef gene product

1 reference

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Structure and expression of tat-, rev-, and nef-specific transcripts of human immunodeficiency virus type 1 in infected lymphocytes and macrophages

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Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1 reference

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Structural features of the cytoplasmic region of CD4 required for internalization

1 reference

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30 September 2017

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1 reference

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Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

1 reference

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Evolution of human immunodeficiency virus type 1 nef and long terminal repeat sequences over 4 years in vivo and in vitro

1 reference

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CD4 and CD8 act as co-receptors during thymic selection of the T cell repertoire

1 reference

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The roles of CD4 and CD8 in T cell activation

1 reference

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Human immunodeficiency virus type 1 glycoprotein precursor retains a CD4-p56lck complex in the endoplasmic reticulum

1 reference

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A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

1 reference

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30 September 2017

Disruption of the CD4-p56lck complex is required for rapid internalization of CD4

1 reference

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Human immunodeficiency virus type 1 nef quasispecies in pathological tissue

1 reference

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Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4

1 reference

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Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis

1 reference

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30 September 2017

The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.

1 reference

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Transient modulation and internalization of T4 antigen induced by phorbol esters.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=236459

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AIDS retrovirus induced cytopathology: giant cell formation and involvement of CD4 antigen

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A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients

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Phosphorylation of CD4 and CD8 molecules following T cell triggering.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=236459

28 June 2018

Endocytosis and recycling of CD4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=236459

28 June 2018

Antibodies to recombinant HIV-1 nef protein detected in HIV-1 infection as well as in nonrisk individuals.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=236459

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Biochemical and biological comparison of HIV-1 NEF and ras gene products

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=236459

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Human immunodeficiency virus type 1 (HIV-1) provirus expression and LTR transcription are repressed in NEF-expressing cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=236459

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Purification and characterization of human immunodeficiency virus type 1 nef gene product expressed by a recombinant baculovirus

1 reference

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Differential endocytosis of CD4 in lymphocytic and nonlymphocytic cells

1 reference

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Natural HIV-1 NEF accelerates virus replication in primary human lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=236459

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Constitutive expression of the nef gene suppresses human immunodeficiency virus type 1 (HIV-1) replication in monocytic cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=236459

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The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits

1 reference

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Rapid phosphorylation and modulation of the T4 antigen on cloned helper T cells induced by phorbol myristate acetate or antigen

1 reference

https://pubmed.ncbi.nlm.nih.gov/8035515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product

1 reference

https://pubmed.ncbi.nlm.nih.gov/8035515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR

1 reference

https://pubmed.ncbi.nlm.nih.gov/8035515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibodies to the nef protein and to nef peptides in HIV-1-infected seronegative individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/8035515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activators of protein kinase C induce dissociation of CD4, but not CD8, from p56lck

1 reference

https://pubmed.ncbi.nlm.nih.gov/8035515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impairment of T Cell Receptor-Dependent Stimulation in CD4+ Lymphocytes after Contact with Membrane-Bound HIV-1 Envelope Glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/8035515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

59 Inhibitors of lysosomal function

1 reference

https://pubmed.ncbi.nlm.nih.gov/8035515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.68.8.5156-5163.1994

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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