Cell adhesion and signalling by cadherins and Ig-CAMs in cancer (Q35667465)

9 August 2017

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title

Cell adhesion and signalling by cadherins and Ig-CAMs in cancer (English)

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9 August 2017

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Ugo Cavallaro

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9 August 2017

Gerhard Christofori

series ordinal

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9 August 2017

language of work or name

English

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publication date

1 February 2004

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9 August 2017

published in

Nature Reviews Cancer

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9 August 2017

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9 August 2017

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9 August 2017

page(s)

118-132

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Sticky business: orchestrating cellular signals at adherens junctions

9 August 2017

cites work

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Untangling Desmosomal Knots with Electron Tomography

31 March 2020

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Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members

31 March 2020

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Inactivation of the E-cadherin-mediated cell adhesion system in human cancers

31 March 2020

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Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

31 March 2020

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A causal role for E-cadherin in the transition from adenoma to carcinoma

31 March 2020

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Epigenetic versus genetic alterations in the inactivation of E-cadherin

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E-cadherin germline mutations in familial gastric cancer.

31 March 2020

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The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells

31 March 2020

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The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

31 March 2020

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The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion

31 March 2020

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A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions.

31 March 2020

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MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer

31 March 2020

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Tumour-associated hypermethylation: silencing E-cadherin expression enhances invasion and metastasis

31 March 2020

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Upregulation of MMPs by soluble E-cadherin in human lung tumor cells.

31 March 2020

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Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis

31 March 2020

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Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene

31 March 2020

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Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex

31 March 2020

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IGF-II induces rapid beta-catenin relocation to the nucleus during epithelium to mesenchyme transition

31 March 2020

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Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis

31 March 2020

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Coendocytosis of cadherin and c-Met coupled to disruption of cell-cell adhesion in MDCK cells--regulation by Rho, Rac and Rab small G proteins

31 March 2020

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Density-dependent inhibition of growth involves prevention of EGF receptor activation by E-cadherin-mediated cell-cell adhesion

31 March 2020

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Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation.

31 March 2020

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E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts

31 March 2020

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Linking colorectal cancer to Wnt signaling

31 March 2020

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E-Cadherin Suppresses Cellular Transformation by Inhibiting β-Catenin Signaling in an Adhesion-Independent Manner

31 March 2020

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E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity

31 March 2020

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Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin

31 March 2020

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31 March 2020

RHO-GTPases and cancer

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Cadherin engagement inhibits RhoA via p190RhoGAP.

31 March 2020

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p120 catenin regulates the actin cytoskeleton via Rho family GTPases

31 March 2020

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The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor

31 March 2020

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Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

31 March 2020

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A role for Rac in Tiam1-induced membrane ruffling and invasion

31 March 2020

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Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

31 March 2020

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Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.

31 March 2020

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Mutated APC and Asef are involved in the migration of colorectal tumour cells

31 March 2020

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Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion

31 March 2020

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Localization of IQGAP1 is inversely correlated with intercellular adhesion mediated by e-cadherin in gastric cancers.

31 March 2020

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Genomic analysis of metastasis reveals an essential role for RhoC

31 March 2020

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An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.

31 March 2020

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Dynamics of intercellular communication during melanoma development

31 March 2020

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Loss of T-cadherin (CDH13, H-cadherin) expression in cutaneous squamous cell carcinoma

31 March 2020

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Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis

31 March 2020

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N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression

31 March 2020

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CAM-FGF receptor interactions: a model for axonal growth

31 March 2020

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N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling

31 March 2020

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N-cadherin-mediated cell contact regulates ovarian surface epithelial cell survival

31 March 2020

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A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor

31 March 2020

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Identification of an N-cadherin motif that can interact with the fibroblast growth factor receptor and is required for axonal growth.

31 March 2020

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Invasion of retinal pigment epithelial cells: N-cadherin, hepatocyte growth factor, and focal adhesion kinase

31 March 2020

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Signal transduction from N-cadherin increases Bcl-2. Regulation of the phosphatidylinositol 3-kinase/Akt pathway by homophilic adhesion and actin cytoskeletal organization

31 March 2020

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The nonreceptor tyrosine kinase fer mediates cross-talk between N-cadherin and beta1-integrins

31 March 2020

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Turn-off, drop-out: functional state switching of cadherins

31 March 2020

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Vascular endothelial (VE)-cadherin: only an intercellular glue?

31 March 2020

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Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis

31 March 2020

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VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells

31 March 2020

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Differential displacement of classical cadherins by VE-cadherin

31 March 2020

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Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells.

31 March 2020

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Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP

31 March 2020

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Polysialylated neural cell adhesion molecule in childhood rhabdomyosarcoma

31 March 2020

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NCAM (neural cell adhesion molecules) expression in malignant mesotheliomas

31 March 2020

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Neural cell adhesion molecules (NCAM) and NCAM-PSA expression in neuroendocrine lung tumors

31 March 2020

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Polysialylated neural cell adhesion molecules expressed in human pituitary tumors and related to extrasellar invasion

31 March 2020

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Polysialyltransferases: major players in polysialic acid synthesis on the neural cell adhesion molecule

31 March 2020

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The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues

31 March 2020

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CEACAM1: a marker with a difference or more of the same?

31 March 2020

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The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity

31 March 2020

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CEA adhesion molecules: multifunctional proteins with signal-regulatory properties

31 March 2020

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Angiogenic properties of the carcinoembryonic antigen-related cell adhesion molecule 1.

31 March 2020

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Inhibition of prostate tumor angiogenesis by the tumor suppressor CEACAM1

31 March 2020

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Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene

31 March 2020

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Tumor suppressing pathways

31 March 2020

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Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers

31 March 2020

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DCC and SMAD4 alterations in human colorectal and pancreatic tumor dissemination

31 March 2020

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The 18q21 region in colorectal and pancreatic cancer: independent loss of DCC and DPC4 expression

31 March 2020

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Netrins and netrin receptors

31 March 2020

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Neural cell adhesion molecule L1: relating disease to function.

31 March 2020

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Identification of potential anticancer drug targets through the selection of growth-inhibitory genetic suppressor elements

31 March 2020

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Overexpression of the cell adhesion molecule L1 is associated with metastasis in cutaneous malignant melanoma

31 March 2020

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Involvement of integrin alpha(v)beta(3) and cell adhesion molecule L1 in transendothelial migration of melanoma cells

31 March 2020

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Mel-CAM-specific genetic suppressor elements inhibit melanoma growth and invasion through loss of gap junctional communication.

31 March 2020

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Isolation and characterization of the major form of human MUC18 cDNA gene and correlation of MUC18 over-expression in prostate cancer cell lines and tissues with malignant progression

31 March 2020

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Activation of Human Endothelial Cells via S-Endo-1 Antigen (CD146) Stimulates the Tyrosine Phosphorylation of Focal Adhesion Kinase p125FAK

31 March 2020

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Differential expression of the cell-adhesion molecule Nr-CAM in hyperplastic and neoplastic human pancreatic tissue

31 March 2020

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Integrin and growth factor receptor crosstalk.

31 March 2020

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Integrin signaling revisited

31 March 2020

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CD44: from adhesion molecules to signalling regulators

31 March 2020

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Early epochal maps of two different cell adhesion molecules

31 March 2020

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Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick development

31 March 2020

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The role of cadherins during primordial germ cell migration and early gonad formation in the mouse

31 March 2020

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Hepatocyte growth factor/scatter factor promotes a switch from E- to N-cadherin in chick embryo epiblast cells.

31 March 2020

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N-cadherin/catenin-mediated morphoregulation of somite formation

31 March 2020

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Developmental defects in mouse embryos lacking N-cadherin

31 March 2020

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Neural cell adhesion molecule-stimulated neurite outgrowth depends on activation of protein kinase C and the Ras-mitogen-activated protein kinase pathway

31 March 2020

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Neural cell adhesion molecule (NCAM) association with PKCbeta2 via betaI spectrin is implicated in NCAM-mediated neurite outgrowth.

31 March 2020

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Neural cell adhesion molecules of the immunoglobulin superfamily: role in axon growth and guidance

31 March 2020

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Impaired neurite outgrowth of src-minus cerebellar neurons on the cell adhesion molecule L1.

31 March 2020

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Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis

31 March 2020

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The GDNF family ligands and receptors - implications for neural development

31 March 2020

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The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands

31 March 2020

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The cadherin-catenin adhesion system in signaling and cancer

31 March 2020

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The role of the cell-cell adhesion molecule E-cadherin in large bowel tumour cell invasion and metastasis

31 March 2020

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E-cadherin expression in the primary tumors and metastatic lymph nodes of poorly differentiated types of rectal cancer

31 March 2020

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Attenuated cells in breast stroma: the missing lymphatic system of the breast.

31 March 2020

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Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis

31 March 2020

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Lymphangiogenesis and cancer metastasis

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1276

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Dimensions Publication ID

9 August 2017

1003923555

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