Multiple levels of cyclin specificity in cell-cycle control (Q28284728)

Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates.

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Swe1 regulation and transcriptional control restrict the activity of mitotic cyclins toward replication proteins in Saccharomyces cerevisiae

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CLB5: a novel B cyclin from budding yeast with a role in S phase

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The cyclin-dependent kinase inhibitor p40SIC1 imposes the requirement for Cln G1 cyclin function at Start

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Directed evolution to bypass cyclin requirements for the Cdc28p cyclin-dependent kinase

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Specialization and targeting of B-type cyclins

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Testing cyclin specificity in the exit from mitosis

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Targeted proteomic study of the cyclin-Cdk module.

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Conservation and function of a potential substrate-binding domain in the yeast Clb5 B-type cyclin

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The role of SWI4 and SWI6 in the activity of G1 cyclins in yeast

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Transcriptional activation of CLN1, CLN2, and a putative new G1 cyclin (HCS26) by SWI4, a positive regulator of G1-specific transcription

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CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae

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High functional overlap between MluI cell-cycle box binding factor and Swi4/6 cell-cycle box binding factor in the G1/S transcriptional program in Saccharomyces cerevisiae

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Roles and regulation of Cln-Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae

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CLN3, not positive feedback, determines the timing of CLN2 transcription in cycling cells

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Saccharomyces cerevisiae G1 cyclins differ in their intrinsic functional specificities

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Cln3 activates G1-specific transcription via phosphorylation of the SBF bound repressor Whi5.

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CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast

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A potential positive feedback loop controlling CLN1 and CLN2 gene expression at the start of the yeast cell cycle

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Positive feedback in the activation of G1 cyclins in yeast

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Clb6/Cdc28 and Cdc14 regulate phosphorylation status and cellular localization of Swi6

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Mechanisms that help the yeast cell cycle clock tick: G2 cyclins transcriptionally activate G2 cyclins and repress G1 cyclins

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The Saccharomyces cerevisiae Start-specific transcription factor Swi4 interacts through the ankyrin repeats with the mitotic Clb2/Cdc28 kinase and through its conserved carboxy terminus with Swi6.

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Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae

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Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity: a mechanism for CLB cluster gene activation

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Cell Cycle-Regulated Transcription through the FHA Domain of Fkh2p and the Coactivator Ndd1p

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Regulation of cell cycle-specific gene expression through cyclin-dependent kinase-mediated phosphorylation of the forkhead transcription factor Fkh2p

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G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast

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F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

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Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6.

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CLB5-dependent activation of late replication origins in S. cerevisiae.

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The anaphase promoting complex/cyclosome: a machine designed to destroy

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APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5.

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APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit

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Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex

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Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex

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Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14.

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Early expressed Clb proteins allow accumulation of mitotic cyclin by inactivating proteolytic machinery during S phase

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Activity of the APC(Cdh1) form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p

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The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

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A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

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Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase

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Distinct subcellular localization patterns contribute to functional specificity of the Cln2 and Cln3 cyclins of Saccharomyces cerevisiae

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Mechanisms controlling subcellular localization of the G(1) cyclins Cln2p and Cln3p in budding yeast

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Differential cellular localization among mitotic cyclins from Saccharomyces cerevisiae: a new role for the axial budding protein Bud3 in targeting Clb2 to the mother-bud neck

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Securin and B-cyclin/CDK are the only essential targets of the APC.

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Concerted mechanism of Swe1/Wee1 regulation by multiple kinases in budding yeast.

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Cdk1-dependent regulation of the mitotic inhibitor Wee1.

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MAPK signaling specificity: it takes two to tango

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Direct inhibition of the yeast cyclin-dependent kinase Cdc28-Cln by Far1.

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Cln3-associated kinase activity in Saccharomyces cerevisiae is regulated by the mating factor pathway

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Pheromone-dependent G1 cell cycle arrest requires Far1 phosphorylation, but may not involve inhibition of Cdc28-Cln2 kinase, in vivo.

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Negative regulation of FAR1 at the Start of the yeast cell cycle.

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Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast

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FAR1 and the G1 phase specificity of cell cycle arrest by mating factor in Saccharomyces cerevisiae

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Cyclin-specific START events and the G1-phase specificity of arrest by mating factor in budding yeast

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G1 cyclins CLN1 and CLN2 repress the mating factor response pathway at Start in the yeast cell cycle

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Potential regulation of Ste20 function by the Cln1-Cdc28 and Cln2-Cdc28 cyclin-dependent protein kinases

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Cell Cycle- and Cln2p-Cdc28p-dependent Phosphorylation of the Yeast Ste20p Protein Kinase

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Accurate quantitation of protein expression and site-specific phosphorylation

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A cell cycle checkpoint monitors cell morphogenesis in budding yeast

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Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast

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Swe1p responds to cytoskeletal perturbation, not bud size, in S. cerevisiae

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Phosphorylation-independent inhibition of Cdc28p by the tyrosine kinase Swe1p in the morphogenesis checkpoint

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Localization of Mad2 to kinetochores depends on microtubule attachment, not tension

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The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins

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Complex formation between Mad1p, Bub1p and Bub3p is crucial for spindle checkpoint function

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Budding yeast Cdc20: a target of the spindle checkpoint.

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The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation

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A Mechanism for Coupling Exit from Mitosis to Partitioning of the Nucleus

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Budding yeast Bub2 is localized at spindle pole bodies and activates the mitotic checkpoint via a different pathway from Mad2

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Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage

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Morphogenesis in the yeast cell cycle: regulation by Cdc28 and cyclins

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Genetic analysis of Cln/Cdc28 regulation of cell morphogenesis in budding yeast

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Genetic control of bud site selection in yeast by a set of gene products that constitute a morphogenetic pathway

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Late-G1 cyclin-CDK activity is essential for control of cell morphogenesis in budding yeast

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Specific inhibition of Elm1 kinase activity reveals functions required for early G1 events

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Control of Mitotic Events by Nap1 and the Gin4 Kinase

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Members of the NAP/SET family of proteins interact specifically with B-type cyclins

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NAP1 acts with Clb1 to perform mitotic functions and to suppress polar bud growth in budding yeast

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Cell cycle-dependent assembly of a Gin4-septin complex

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Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast

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Cell cycle-dependent phosphorylation of the DNA polymerase epsilon subunit, Dpb2, by the Cdc28 cyclin-dependent protein kinase

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Interaction between yeast Cdc6 protein and B-type cyclin/Cdc28 kinases

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The cyclin-dependent kinase Cdc28p regulates distinct modes of Cdc6p proteolysis during the budding yeast cell cycle.

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The stability of the Cdc6 protein is regulated by cyclin-dependent kinase/cyclin B complexes in Saccharomyces cerevisiae

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Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control

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G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus

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Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.

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Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms

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Interaction of the S-phase cyclin Clb5 with an "RXL" docking sequence in the initiator protein Orc6 provides an origin-localized replication control switch.

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Two-faced cyclins with eyes on the targets

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Multi-step control of spindle pole body duplication by cyclin-dependent kinase

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The budding yeast spindle pole body: structure, duplication, and function

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Cdc28/Cdk1 regulates spindle pole body duplication through phosphorylation of Spc42 and Mps1.

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The yeast protein kinase Mps1p is required for assembly of the integral spindle pole body component Spc42p

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Targets of the cyclin-dependent kinase Cdk1

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Clb5-associated kinase activity is required early in the spindle pathway for correct preanaphase nuclear positioning in Saccharomyces cerevisiae

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Coordinated spindle assembly and orientation requires Clb5p-dependent kinase in budding yeast

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Modes of spindle pole body inheritance and segregation of the Bfa1p-Bub2p checkpoint protein complex

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Kar9p is a novel cortical protein required for cytoplasmic microtubule orientation in yeast

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The cortical localization of the microtubule orientation protein, Kar9p, is dependent upon actin and proteins required for polarization

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Yeast Cdk1 translocates to the plus end of cytoplasmic microtubules to regulate bud cortex interactions

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Asymmetric loading of Kar9 onto spindle poles and microtubules ensures proper spindle alignment

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Cdk1-Clb4 controls the interaction of astral microtubule plus ends with subdomains of the daughter cell cortex

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The CLIP-170 homologue Bik1p promotes the phosphorylation and asymmetric localization of Kar9p

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Asymmetric recruitment of dynein to spindle poles and microtubules promotes proper spindle orientation in yeast.

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Yeast Hct1 is a regulator of Clb2 cyclin proteolysis

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A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae.

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A non-proteolytic function of separase links the onset of anaphase to mitotic exit

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The Spindle Assembly and Spindle Position Checkpoints

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Cdc14 activates cdc15 to promote mitotic exit in budding yeast.

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Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase

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Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus

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Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast.

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Net1 stimulates RNA polymerase I transcription and regulates nucleolar structure independently of controlling mitotic exit.

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Evolution of the cell cycle

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