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A Novel Humanized Mouse Model With Significant Improvement of Class-Switched, Antigen-Specific Antibody Production

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Milton-Genesis
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57 views7 pages

A Novel Humanized Mouse Model With Significant Improvement of Class-Switched, Antigen-Specific Antibody Production

Uploaded by

Milton-Genesis
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PPT, PDF, TXT or read online on Scribd
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A novel humanized mouse model with significant

improvement of class-switched, antigen-specific antibody


production

by Hua Yu, Chiara Borsotti, Jean-Nicolas Schickel, Shu Zhu, Till Strowig, Elizabeth
E. Eynon, Davor Frleta, Cagan Gurer, Andrew J. Murphy, George D. Yancopoulos,
Eric Meffre, Markus G. Manz, and Richard A. Flavell

Blood
Volume 129(8):959-969
February 23, 2017

©2017 by American Society of Hematology


Validation of human IL-6 expression in knock-in mice.

Hua Yu et al. Blood 2017;129:959-969

©2017 by American Society of Hematology


Human CD45+ hematopoietic cell and T-lymphocyte development in RG SKI (open dots) and RG
SKI IL-6 mice (closed dots).

Hua Yu et al. Blood 2017;129:959-969

©2017 by American Society of Hematology


Characteristics of human CD19+ cells recovered from blood, BM, and spleen of RG SKI and RG
SKI IL-6 mice.

Hua Yu et al. Blood 2017;129:959-969

©2017 by American Society of Hematology


Improved total IgG and antigen-specific IgG responses in RG SKI IL-6 mice.

Hua Yu et al. Blood 2017;129:959-969

©2017 by American Society of Hematology


IGHV gene features from IgG+ memory B-cell antibodies.

Hua Yu et al. Blood 2017;129:959-969

©2017 by American Society of Hematology


Human IL-6 promotes the generation of antigen-specific IgG-switched B cells in humanized
mice.

Hua Yu et al. Blood 2017;129:959-969

©2017 by American Society of Hematology

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