51

Chapter 3 Thorax

The thoracic cage and the intercostal space The thoracic cavity, lungs and pleura 52 The heart 56

51

Clavicle Suprasternal notch

The thoracic cage and the intercostal space

The bony thoracic cage is formed by the 12 thoracic vertebrae at the back, the sternum in front and 12 pairs of ribs in between (Fig. 3.1). The upper seven pairs of ribs articulate anteriorly direct with the sternum through their respective costal cartilages. The costal cartilage of ribs 8, 9 and 10 articulates with that of the rib above. These ribs with the xiphisternum form the lower costal margin. The lowermost point of the thoracic cage is the 10th costal cartilage. The space between two adjacent ribs is known as the intercostal space. Thus there are 11 intercostal spaces on each side. The junction between the manubrium and the body of the sternum is the sternal angle. The second costal cartilage articulates at the sternal angle (Figs 3.1, 3.2). This is an important landmark and corresponds to the level of the lower border of the 4th thoracic vertebra. The seventh costal cartilage anteriorly articulates at the junction between the body of the sternum and the xiphisternum. The 8th, 9th and 10th ribs each articulate with the rib above. The 11th and 12th ribs are the oating ribs as they have no connection to bone or cartilage in front. See Clinical box 3.1.
Sternal angle

Lower costal margin

Fig. 3.1

Surface anatomy of the chest wall.

Clinical box 3.1

Rib fractures and stove-in-chest
Rib fractures can be fracture of a single rib or can be multiple fractures and are caused by direct blow on the rib or by a crush injury. In a severe crush injury several ribs can fracture in front as well as behind producing a loose segment of chest wall disconnected from the rest. This is known as a stove-in-chest. The loose segment may show paradoxical movements during respiration i.e. moves inwards during inspiration and blows out during expiration. Stove-in-chest is a serious condition needing urgent intubation and positive pressure ventilation using a respirator as well as a chest drain.

Surface anatomy
The sternal angle is palpable on the surface as a transverse ridge (Fig. 3.1). This landmark is used to palpate the second costal cartilage and the second rib. It is possible to identify the other ribs as well as intercostal spaces by counting down from the second rib. The rst rib is not palpable as it is under the clavicle. Ribs 11 and 12 are rudimentary, conned to the back covered by muscles and hence are not palpable.

The intercostal space

The intercostal space (Fig. 3.3) contains the external intercostal, the internal intercostal and the innermost intercostal muscles arranged in three layers. The neurovascular bundle, consisting of the intercostal nerve and vessels, lies in between the internal and the innermost intercostals. The external intercostal muscle bres are directed downwards and forwards. In the anterior part the muscle bres are replaced by a membrane. The internal intercostal

bres lie in the opposite direction to those of the external. The neurovascular bundle lies between the internal and the innermost intercostal muscles. If it is necessary to insert a chest drain or a needle into the intercostal space it is always placed in the lower part of the space to avoid damage to the neurovascular bundle (which lies along the lower border of the rib along the upper part of the space). The neurovascular bundle consists of, from above downwards, intercostal vein, artery and nerve. See Clinical box 3.2. The intercostal nerves are the anterior rami of the rst 11 thoracic nerves. These supply the intercostal muscles, the skin of the chest wall as well as the parietal pleura. The lower intercostal nerves, 7th downwards, supply the

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HUMAN ANATOMY
Suprasternal notch

Clinical box 3.2

Thoracocentesis, insertion of a chest drain
Clavicle Manubrium sternum Sternal angle 2nd costal cartilage Body of sternum

Xiphisternum

7th costal cartilage

10th costal cartilage

Fig. 3.2

Bony thoracic cage.

Internal intercostal muscle

Intercostal artery

Insertion of a chest tube into the pleural cavity is required to remove large amounts of serous uid, blood, pus or air. The site of insertion of the tube is usually at the 5th intercostal space just anterior to the midaxillary line on the affected side. This site will avoid the tube going through the pectoral muscles which lie more anteriorly and will avoid possible damage of liver (right side) and spleen (left side) which are overlapped by the pleural cavity more inferiorly (see Clinical box 3.3). Nerve to serratus anterior lies at the level of insertion of the tube and may be damaged occasionally, causing winging of the scapula (see Clinical box 2.1). A needle thoracocentesis done in a critically ill patient with tension pneumothorax may be life saving. An over the needle catheter is inserted into the pleural cavity on the side of the tension pneumothorax through the second intercostal space in the midclavicular line. Insertion medial to the midclavicular line has a potential danger of damaging the great vessels in the mediastinum. The needle or chest drain is always inserted superior to the rib (lower part of the intercostal space) to avoid damaging the neurovascular bundle. Damage of the intercostal nerve will cause neuritis and pain (neuralgia) and puncture of the vessels may result in bleeding into the pleural cavity (haemothorax). The parietal pleura, the periosteum and other structures in the area of needle insertion and chest drain have rich innervation and hence a good local anaesthesia is required for procedures mentioned above.

External intercostal muscle

Intercostal nerve Internal thoracic artery Rib

lateral to the sternum. In the sixth intercostal space it divides into its two terminal branches, the musculophrenic and superior epigastric arteries, the latter entering the anterior abdominal wall by passing through the diaphragm The anterior intercostal arteries are branches of the internal thoracic artery or those of its musculophrenic branch. Most of the posterior intercostal arteries are derived from the descending thoracic aorta. Anastomoses between the anterior and posterior intercostal arteries are important collateral channels for circulation in cases of obstruction to the blood ow in the aorta anywhere beyond the origin of the left subclavian artery.

The thoracic cavity, lungs and pleura

Rectus abdominus

Fig. 3.3

Intercostal spaces (left side).

The thoracic cavity contains on either side the right and left lungs surrounded by the pleural cavities and the mediastinum in between.

The lungs and pleural cavities

anterior abdominal wall as well. Segments of skin supplied by the intercostal nerves are common sites of vesicles in Herpes zoster, a viral infection affecting the spinal nerve ganglia spreading through the intercostal nerves. The internal thoracic artery, a major artery on the anterior aspect of the chest wall, is a branch of the subclavian artery and it descends vertically downwards lying about 1cm See Figures 3.43.11. The right lung is subdivided into superior, middle and inferior lobes by an oblique ssure and a horizontal ssure (Figs 3.4 and 3.5). The left lung usually has only two lobes, a superior and an inferior with an oblique ssure in between. Each lung has an apex which extends about 3cm above the clavicle into the neck, a costal surface, a mediastinal surface and a base or diaphragmatic

Thorax

53

Trachea Left common carotid artery Brachiocephalic trunk Left brachiocephalic vein

Upper lobe

Upper lobe
Anterior border of left lung Anterior border of right lung

Horizontal fissure

Middle lobe

Pericardium

Fig. 3.4

The lungs in situ anterior aspect.

Upper lobe
Oblique fissure left lung

Oesophagus

Upper lobe

Arch of the aorta Oblique fissure right lung

Thoracic (descending) aorta

Lower lobe
Posterior border of left lung

Lower lobe
Posterior border of right lung

Lower border of right lung Lower border of left lung Right dome of diaphragm Left dome of diaphragm

Fig. 3.5

The lungs in situ posterior aspect.

surface (Figs 3.6 and 3.7). The anterior border of the lung separates the costal and the mediastinal surfaces whereas the lower border is between the costal and the diaphragmatic surface (Fig. 3.6). The root of the lung connects the lung to the mediastinum and consists of, anterior to posterior, two pulmonary veins, the pulmonary artery and the bronchus. The pulmonary veins are at a lower level compared with the pulmonary artery (Figs 3.7 and 3.8). The area where these structures enter the lung is the hilum of the lung. These structures are enclosed in a sleeve of pleura which loosely

hangs down in its lower part as the pulmonary ligament. The right main bronchus gives off the superior lobar bronchus outside the lung. All the branches of the left bronchus are given off inside the lung. The root of the lung also contains the bronchial arteries supplying the bronchi and bronchioles, the pulmonary plexus of autonomic nerves innervating the lung as well as the lymph nodes draining the lung. The phrenic nerve lies in front of the root of the lung and the vagus nerve behind. The right bronchus is shorter, wider and more vertical than the left. The angle between the two bronchi is about

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HUMAN ANATOMY
Anterior border Pulmonary artery branches

Apex

Anterior border Apex Upper lobe Posterior border Oblique fissure Horizontal fissure Oblique fissure Lower lobe Right bronchus Superior lobar bronchus

Middle lobe Lower border Pulmonary veins

Oblique fissure

Fig. 3.6

Costal surface of the right lung.

Fig. 3.7

Mediastinal surface of the right lung.

Apex

Groove for arch of aorta Oblique fissure Left pulmonary artery Left main bronchus Left inferior pulmonary vein Groove for descending aorta Cardiac impression Oblique fissure Left superior pulmonary vein

Fig. 3.8

Mediastinal surface of the left lung.

70 in the adult; 25 to the right and 45 to the left from the midline. Therefore foreign bodies getting into the trachea tend to go to the right bronchus rather than into the left. At birth the bifurcation angle is about 110 with both bronchi angulating equally from the midline (55 each way). The lung is surrounded by the pleural cavity, the potential space between the two layers of pleura. The outer parietal

layer of pleura lines the thoracic cavity and the inner visceral or pulmonary layer closely ts on to the surface of the lung. The two layers become continuous with each other at the root of the lung. The parietal pleura lining the diaphragm is known as the diaphragmatic pleura and that lining the mediastinum as the mediastinal pleura. See Clinical box 3.3.

Thorax
Clavicle

55

2 Sternum

Horizontal fissure

Cardiac notch

Oblique fissure

Lower border of lung Lower border of pleura

10

10

Fig. 3.9

Surface relationship of the lungs and pleural cavities. The numbers indicate those of the ribs and costal cartilages.

Clinical box 3.3

Surface anatomy of the lung and pleura
Knowledge of the extent of the lung and pleura is clinically important (Fig. 3.9). Their lower parts overlap abdominal organs such as the liver, kidney and spleen. On the apical pleura lie the subclavian vessels and the brachial plexus. The stellate ganglion of the sympathetic trunk lies behind the apex of the lung and pleura on the neck of the rst rib. Pancoasts tumour affecting the apex of the lung may involve these structures when it spreads locally. Cannulation of the subclavian vein may inadvertently produce a pneumothorax (air in the pleural cavity) resulting in collapse of the lung. Procedures such as exposure of the kidney, kidney and liver biopsies may also produce pneumothorax. This is due to the fact that the diaphragm is dome shaped and hence the lower parts of the lung and pleura overlap the upper abdominal organs (separated, of course, by the diaphragm). When the lung elds are markedly hyperinated, as in emphysema, the liver is pushed down by the diaphragm and may be palpable. The apex of the lung and the surrounding pleural cavity extends about 3cm above the medial part of the clavicle. The apical pleura is covered by a fascia, the suprapleural membrane (Sibsons fascia), attached to the inner border of the rst rib. This fascia prevents the lung and pleura expanding too much into the neck during deep inspiration. From the apex, the anterior border of the pleural cavity descends behind the sternoclavicular joint to reach the midline at the level of the sternal angle. (Here the two pleural cavities are close to each other.) The anterior limit of the right pleural cavity descends vertically downwards in the midline from the sternal angle to the level of the sixth costal cartilage. From there the lower border extends laterally, crossing the eighth rib in the midclavicular line, the 10th rib in the midaxillary line and then ascends to the middle of the 12th rib at the back. The posterior border then ascends almost vertically upwards in the paravertebral region. A midline sternotomy (splitting of the sternum) is done to open up the chest cavity for cardiac surgery. During this procedure the right lung and pleura will be seen extending up to the midline, and occasionally even beyond, just behind the sternum. From the sternal angle the anterior border of the left pleural cavity deviates laterally to the lateral border of the sternum. The extent of the lower and the posterior margins are similar to those on the right. The surface marking of the lung is the same as that of the pleura except for the lower margin and the cardiac notch (Fig. 3.9). The lower margin of the lung is about two ribs higher than the lower margin of the pleura. Because of the bulge of the heart and pericardium, the anterior border of the left lung deviates laterally from the sternal angle to the apex of the heart (usually in the fth intercostal space a little inside the midclavicular line) producing the cardiac notch. The oblique ssure of the lung lies along the sixth rib on both sides and the horizontal ssure of the right lung extends anteriorly from the midaxillary line along the fourth rib.

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HUMAN ANATOMY

Left clavicle Trachea Right bronchus

Right superior lobe bronchus Right middle lobe bronchus Right inferior lobe bronchus

Left bronchus Left superior lobe bronchus

Left inferior lobe bronchus

Fig. 3.10

Bronchogram left anterior oblique view.

Clinical box 3.4

Bronchopulmonary segments
A bronchopulmonary segment is dened as the area of lung ventilated by a tertiary (branch immediately following the lobar branch) division of the bronchial tree. Each segment has its own bronchus and a pulmonary artery branch. Pulmonary veins are intersegmental. There are 10 such segments for the right lung and nine for the left. Conditions such as lung abscess may be localised to these segments and patients can be positioned accordingly to facilitate postural drainage. Secretions collected in anterior segments drain better if the patient lies on the back, and posterior ones in the prone position. Lumen of the trachea, main bronchi and the commencement of the segmental bronchi can be visualised during bronchoscopy.

Respiratory bronchiole

Alveolar duct

Alveolus

Fig. 3.11

The bronchioles and alveoli.

The trachea, bronchi and bronchioles

The trachea, which is slightly to the right of the midline, divides at the carina into right and left main bronchi. The right main bronchus is more vertical than the left and, hence, inhaled material is more likely to pass into it. The right main bronchus divides into three lobar bronchi (upper, middle and lower), whereas the left only into two (upper and lower) (Fig. 3.10). Each lobar bronchus divides into segmental and subsegmental bronchi. There are about 25 generations of bronchi and bronchioles between trachea and the alveoli; the rst 10 are bronchi and the rest bronchioles (Fig. 3.11). The bronchi have walls consisting of cartilage and smooth muscle, epithelial lining with cilia and goblet cells, submucosal mucous glands and endocrine cells containing 5-hydroxytryptamine. The bronchioles are tubes less than 2mm in diameter and are also known as small airways. They have no cartilage or submucosal glands. Their epithelium has a single layer of ciliated cells but only few goblet cells and Clara cells secreting a surfactant-like substance. See Clinical box 3.4.

The alveolar ducts and alveoli

Each respiratory bronchiole supplies approximately 200 alveoli via alveolar ducts. There are about 300 million alveoli in each lung and their walls have type I and type II pneumocytes. Type II pneumocytes are the source of surfactant. The type I pneumocytes and the endothelial cells of adjoining capillaries constitute the bloodair barrier, the thickness of which is about 0.22mm.

The heart
Borders and surfaces of the heart
The heart has an anterior or sternocostal surface, formed mostly by the right ventricle, an inferior or diaphragmatic surface, formed mostly by the left ventricle, a base or posterior surface, formed by the left atrium, and an apex, formed entirely by the left ventricle. The borders of the heart (Fig. 3.12) are the right border, formed by the right atrium, the inferior border, formed by the right ventricle, the left or obtuse border, formed mostly by the left ventricle with the left auricle at its superior end (Fig. 3.13).

Thorax
The apex beat is dened as the lower-most and lateralmost cardiac pulsation in the precordium, normally felt inside the midclavicular line in the fth left intercostal space (approximately 6cm to the left of the midline) (Fig. 3.13). However it is felt in the anterior axillary line when lying on the left side. The right border of the heart extends from the third to the sixth right costal cartilage approximately 3cm to the right of the midline, the inferior border from the lower end of the right border to the apex, and the left border from the apex to the second left intercostal space approximately 3cm from the midline. See Clinical box 3.5.

57

Blood supply of the heart

The heart muscle is supplied by the right and left coronary arteries and is drained by the cardiac veins (Figs 3.143.19). The coronary arterial supply is of great clinical importance. Its occlusion is the chief cause of death in the western world. The right coronary artery arises from the anterior aortic sinus. It passes between the pulmonary trunk and the right atrium to lie in the atrioventricular groove (Fig. 3.14). It winds round the inferior border to reach the diaphragmatic surface where it anastomoses with the terminal part of the left coronary artery. It gives off an artery to the sinoatrial node, the right (acute) marginal artery and the posterior interventricular artery, which is also known as the posterior descending artery (Fig. 3.15).

Blood vessels in the lung

Trachea

Clavicle

Ribs

Clinical box 3.5

Apex beat
Apex beat is the lower and lateral-most cardiac pulsation in the precordium, its normal site being just medial to the midclavicular line in the fourth or fth left intercostal space. It may be normally felt in the anterior axillary line when lying on the left side. There are abnormal forms of apex beats in various clinical conditions. A heaving apex beat which is forceful and sustained may be present in hypertension and aortic stenosis (pressure overload) whereas a thrusting one which is forceful but not sustained is a sign of mitral or aortic regurgitation (volume overload). A tapping apex beat is a sudden but brief pulsation and occurs in mitral stenosis. Apex beat may be missing (i.e. not palpable) in obesity, pleural effusion, pericardial effusion and emphysema.

Heart shadow

Diaphragm Costo-diaphragmatic recess

Diaphragm

Fig. 3.12

Posteroanterior radiograph of the chest.

Pulmonary valve Left auricle

Aortic valve Right atrium Tricuspid valve T Right ventricle M

Mitral valve Left ventricle

Fig. 3.13

Surface projections of the heart. A, P, T and M indicate auscultation areas for the aortic, pulmonary, tricuspid and mitral valves.

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Left auricle Ascending aorta Pulmonary trunk Anterior interventricular artery Right coronary artery Right (acute) marginal artery Diagonal artery Obtuse (left) marginal artery Left ventricle Left coronary artery

Right ventricle

Apex

Fig. 3.14

Coronary arteries anterior aspect of the heart.

Right atrium Inferior vena cava

Left atrium

Coronary sinus Circumflex artery Left ventricle Middle cardiac vein Right ventricle Right (acute) marginal artery Obtuse (left) marginal artery Posterior interventricular artery

Anterior interventricular artery

Fig. 3.15

Coronary arteries posteroinferior aspect of the heart.

The left coronary artery arises from the left posterior aortic sinus. It passes behind the pulmonary trunk and the left auricle to reach the atrioventricular groove where it divides into the circumex and the anterior interventricular (anterior descending) arteries, both of equal size (Figs 3.14, 3.15). The circumflex artery winds round the left margin where it gives off the left (obtuse) marginal artery and reaches the diaphragmatic surface to anastomose with the right coronary artery. The anterior descending artery (LAD), also known as the widow maker because many men die of blockage of this artery, descends in the interventricular septum and gives off ventricular branches, septal branches as well as the diagonal artery. It then winds round the apex reaching the diaphragmatic surface to anastomose with the posterior descending artery. The main stem of the left coronary artery varies in length between 4mm and 10mm. In 10% of the

population in whom the left coronary is larger and longer than usual left dominance the posterior descending artery arises from it instead of from the right coronary. Another 10% have co-dominant coronary circulation where both left and right coronaries contribute equally to the posterior interventricular artery. In a third of the population the left main stem divides into three branches instead of two, the third being a branch lying between the circumflex and the anterior descending on the lateral aspect of the left ventricle. The blood supply of the conducting system is of clinical importance. In about 60% of the population the sinoatrial node is supplied by the right coronary and in the rest by the circumex branch of the left coronary. However occasionally (3%) it can have a dual supply. The atrioventricular node is supplied by the right coronary in 90% and the circumex in 10%.

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59

Left coronary artery: RAO view

Right coronary artery RAO view Main RCA 1st diagonal L1 main stem Septals Right ventricular branch Circumflex

Left anterior descending LAD

Apex Posterior descending artery

Circumflex

Fig. 3.16

Right coronary arteriogram right anterior oblique view.

Fig. 3.18

Left coronary arteriogram right anterior oblique view.

Left coronary artery: lateral view

T. spine Upper ventricular Sternum

Diagonal Right ventricular branch Posterior descending artery Circumflex

Right coronary artery: LAO view

LAD Septals Obtuse marginal

Fig. 3.17

Right coronary arteriogram left anterior oblique view.

Fig. 3.19

Left coronary arteriogram lateral view.

Cardiac veins accompany the arteries. Most of them are tributaries of the coronary sinus, a sizable vein lying in the posterior part of the atrioventricular groove and opening into the right atrium. The great cardiac vein accompanies the anterior interventricular artery; the middle cardiac vein accompanies the posterior interventricular artery and the small cardiac vein accompanies the marginal artery. Anterior cardiac veins seen on the anterior wall of the right ventricle drain directly into the right atrium. Additionally there are very small veins on the various walls venae cordis minimae, draining directly into the cardiac cavity. See Clinical box 3.6.

The pericardium
The heart lies within the pericardial cavity, in the middle mediastinum. The pericardial cavity is similar in structure

and function to the pleural cavity. The pericardium provides a friction-free surface for the heart to accommodate its sliding movements. Components of the pericardium are the brous pericardium and the serous pericardium, the former being a collagenous outer layer fused with the central tendon of the diaphragm. The serous pericardium consists of a parietal layer which lines the inner surface of the brous pericardium and a visceral layer which lines the outer surface of the heart and the commencement of the great vessels. The pericardial cavity is the space between the parietal and the visceral layers. Two regions of the pericardial cavity have special names. The transverse sinus of the pericardial cavity lies between the ascending aorta and the pulmonary trunk in front and the venae cavae and the atria behind. The pericardial space

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HUMAN ANATOMY

Clinical box 3.6

Coronary artery disease
Occlusion of a coronary artery or its branch causes myocardial infarction which is cell death of the cardiac musculature due to inadequate blood supply. A partial occlusion may manifest as angina which typically is felt as a deep pain in the sternal area radiating to the left arm and left side of the neck. The changes caused by occlusion are based on the distribution of the coronary artery branches. Right coronary artery occlusion leads to inferior myocardial infarction, often associated with dysrhythmia (abnormal heart beats) due to ischaemia of SA node and/or AV node, parts of the conducting system. Occlusion of the left coronary artery or its branches leads to anterior and/or lateral myocardial infarction, often with substantial ventricular damage and very poor prognosis. Coronary arteries and their branches can be visualised by selectively catheterising each coronary artery and injecting a radio-opaque dye (usually iodine-containing). Several procedures are now available to treat coronary artery disease. In an angioplasty a catheter with a small inatable balloon attached to its tip is passed into the coronary artery (via the femoral, external and common iliac and aorta). The balloon is inated to widen the artery by attening the atheromatous plaque. In the coronary artery bypass graft operation a small segment of the great saphenous vein is connected to the ascending aorta or to the coronary artery proximal to the obstruction and the distal end of the segment is then attached to the coronary artery distal to the narrowing bypassing the obstruction. The radial artery and the internal thoracic artery are also commonly used for bypass surgery.

Pulmonary vein

Left atrium Left ventricle Oblique sinus

Inferior vena cava

Parietal layer of pericardium lining the fibrous pericardium

Fig. 3.20

Pericardial cavity opened up and the heart lifted up to show the oblique sinus.

behind the left atrium is the oblique sinus (Fig. 3.20). The oblique sinus separates the left atrium from the oesophagus. Anteriorly the pericardium is related to the sternum, third to sixth costal cartilages, lungs and the pleura. Posterior relations are oesophagus, descending aorta and T5T8 vertebrae. Laterally on either side lie the root of the lung, mediastinal pleura and the phrenic nerve. Innervation of the brous and the parietal layer of serous pericardium is by the phrenic nerves. Pericardial pain originates in the parietal layer and is transmitted by the phrenic nerves. The pericardial cavity is closest to the surface at the level of the xiphoid process of sternum and the sixth costal cartilages. See Clinical box 3.7.

Clinical box 3.7

Pericardiocentesis
Diseases of the pericardium can cause accumulation of uid or blood in the pericardial cavity. Blood can also accumulate in the pericardial cavity as a result of trauma. To remove uid or blood from the pericardial cavity a needle is inserted into the angle between the xiphoid process and the left seventh costal cartilage and is directed upwards at an angle of 45 towards the left shoulder. The needle passes through the central tendon of the diaphragm before entering the pericardial cavity. which bring systemic venous blood into the smooth part of the atrium. The coronary sinus opens anterior to the opening of the inferior vena cava. Developmentally the smooth part of the atrium is derived from the sinus venosus of the primitive cardiac tube and the rough part which has

Interior of the chambers of the heart The right atrium

The right atrium (Fig. 3.21) has a smooth and a rough part which are separated by a vertical ridge, the crista terminalis, extending between the superior and inferior venae cavae

Thorax
muscular ridges known as musculae pectinatae from the primitive atrium. The fossa ovalis (Fig. 3.21), an oval depression on the interatrial wall, is the remnant of the foramen ovale in the fetus. Before birth the foramen ovale allowed blood to ow from the right atrium to the left atrium bypassing the lungs. At birth when the lungs begin to function the foramen ovale closes to produce the fossa ovalis. (Fig. 3.22). The chordae tendineae connect the papillary muscles to the tricuspid valve cusps. These prevent the valve cusps being everted into the atrium during ventricular systole. Failure of this mechanism due to breakage of the papillary muscle or chordae tendineae causes tricuspid incompetence and regurgitation of blood back into the atrium during ventricular systole. When this happens blood from the atrium can pool back into the liver and the neck veins causing enlarged neck veins and palpable liver as the superior and inferior venae cavae do not have valves. The septomarginal trabecula (moderator band) is a muscular ridge extending from the interventricular septum to the base of the anterior papillary muscle of the heart. The moderator band is a part of the conducting system of the heart which regulates the cardiac cycle. The infundibulum leads on to the orice of the pulmonary trunk. The pulmonary orice has the pulmonary valve with three semilunar cusps. Each cusp has a thickening in the centre of its free edge.

61

The right ventricle

The right ventricular wall is thicker than that of the atrium. The tricuspid orice is guarded by the tricuspid valve which has an anterior, posterior and a septal cusp. The interior of the ventricle has muscular ridges known as trabeculae carneae as well as the anterior, posterior and septal (small) papillary muscles and the chordae tendineae

The left atrium

Right auricle Superior vena cava

The left atrium which develops by a combination of absorption of the pulmonary veins as well as from the primitive atrium has the openings of the four pulmonary veins. The mitral orice separates the left atrium from the left ventricle.

The left ventricle

Musculi pectinati

Crista terminalis Coronary sinus Inferior vena cava

Fossa ovalis

Fig. 3.21

Interior of the right atrium.

The walls of the left ventricle are about three times thicker than those of the right ventricle because of the increased resistance of the systemic circulation compared with that of the pulmonary circulation. The mitral orice is guarded by the mitral valve with an anterior and a posterior cusp. The large anterior cusp lies between the aortic and mitral orices. The trabeculae carneae, papillary muscles and chordae tendineae are similar to those in the right ventricle. The aortic orice has the aortic valve (Fig. 3.23) with the three semilunar aortic cusps, one anterior and two posterior in the anatomical position of the heart. These are thicker than those of the pulmonary valves to cope with the increased pressure. Alongside each cusp there is a dilation, the aortic sinus. The coronary arteries originate from the

Cusps of pulmonary valve

Infundibulum Trabeculae carneae Interventricular septum Anterior cusp of tricuspid valve Chordae tendineae Anterior papillary muscle Septal cusp of tricuspid valve Posterior cusp of tricuspid valve Interventricular septum

Posterior papillary muscle

Fig. 3.22

Interior of the right ventricle.

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HUMAN ANATOMY

Aorta Anterior (right coronary) sinus Aortic valve cusps Aortic vestibule Anterior cusp of mitral valve Chordae tendineae Posterior cusp of mitral valve

Papillary muscles

Fig. 3.23

Interior of the left ventricle.

Clinical box 3.8

Valves, heart sounds and murmurs
The valves between the atria and the ventricles, i.e. the tricuspid and the mitral valves, prevent regurgitation of blood from the ventricles back into the atria during ventricular contraction (systole). Similarly the pulmonary and aortic valves prevent regurgitation during diastole (relaxation of ventricle) from these vessels back into the ventricles. Closure of the tricuspid and mitral valves occurs at the beginning of systole and causes the rst heart sound and closure of the aortic and pulmonary valves, which happens at the beginning of diastole, the second sound. Thus the interval between the rst and the second heart sounds is the period of ventricular systole and that between the second and the next rst sound is the diastole. A hissing sound heard during systole is a systolic murmur and that during diastole is a diastolic murmur. Murmurs are caused by blood ow through narrow orice or leaking valves. Pulmonary or aortic valve stenosis (narrowing) cause systolic murmur. It can also be heard in mitral or tricuspid incompetence (regurgitation). A diastolic murmur, on the other hand, is a characteristic of mitral or tricuspid stenosis. It is also a sign of aortic or pulmonary valve incompetence.

Clinical box 3.9

Areas of auscultation
The two heart sounds and the abnormal murmurs are caused by turbulence and vibrations inside the ventricles, the aorta or the pulmonary trunk. This is best heard where the particular chamber or vessel is closer to the surface. Thus the mitral valve closure produces vibrations in the left ventricle and the sound is best heard where the left ventricle is closer to the surface, i.e. where the apex beat is felt. Mitral valve therefore is auscultated at the apex, tricuspid at the lower end of sternum pulmonary valve at the second intercostal space on the left side just outside the lateral border of sternum, and the aortic valve in the second intercostal space close to the lateral border of the sternum on the right side (Fig. 3.13).

SA node

AV node

Left bundle branch

sinuses, the right from the anterior (also known as the right coronary sinus) and the left from the left posterior aortic sinus (also known as the left coronary sinus). The interventricular septum which has the muscular and the membranous parts bulges into the right ventricle and separates the left ventricle from the right. See Clinical boxes 3.8 and 3.9.

The conducting system of the heart

Specialised cardiac muscle cells initiate and regulate the heart-beat. The sinoatrial node (SA node) or pacemaker of the heart initiating the heart-beat is situated in the right atrium at the upper end of the crista terminalis (Fig. 3.24). From there the cardiac impulse spreads through the atrial musculature to reach the AV node (atrioventricular node) which is situated in the interatrial septum near the opening of the coronary sinus. After a brief pause there the impulse passes into the atrioventricular bundle of His (AV bundle). The AV bundle which starts from the AV node passes
Atrioventricular bundle Right bundle branch

Fig. 3.24

The conducting system of the heart.

through the brous ring at the atrioventricular junction to reach the membranous part of the interventricular septum where it divides into a right and left bundle branch. The atrioventricular bundle is the only pathway through which impulses can reach the ventricles from the atrium. The left

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63

Right vagus Right brachiocephalic vein Trachea Azygos vein Left brachiocephalic vein Superior vena cava Right phrenic nerve Right bronchus Right sympathetic trunk Branches of right pulmonary artery

Splanchnic nerves Oesophagus Right pulmonary veins

Pericardium

(A)

Sympathetic trunk

Oesophagus

Trachea Azygos vein Right brachiocephalic vein Right vagus

Arch of aorta

Superior lobe bronchus

Superior vena cava

Pulmonary artery Right bronchus Pulmonary veins

Greater splanchnic nerve (B)

Right phrenic nerve

Fig. 3.25 a & b

Right side of the mediastinum after removal of the right lung and pleura. Viewed from the right side.

and right bundles descend towards the apex and break up into Purkinje bres which activate the musculature of the ventricle in such a way that the papillary muscles contract rst followed by the simultaneous contraction of both the ventricles from apex towards the base.

superior mediastinum lies above the horizontal plane joining the sternal angle to the lower border of T4 vertebra. The middle mediastinum contains the heart and pericardium; the anterior mediastinum is in front of this and the posterior mediastinum behind.

The mediastinum
The mediastinum is the region between the two pleural cavities. It contains the heart, great vessels, trachea, oesophagus and many other structures. The mediastinum is divided into four parts for descriptive purposes. The

The brachiocephalic vein and the superior vena cava

The brachiocephalic vein, one on each side, is formed by the union of the subclavian and the internal jugular veins. The right and left brachiocephalic veins join together to form the superior vena cava which drains into the right atrium (Fig. 3.25).

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HUMAN ANATOMY

Left subclavian artery

Left superior. intercostal vein Left vagus Left phrenic nerve Arch of the aorta Left pulmonary artery Descending thoracic aorta

Pericardium Left sympathetic trunk

Greater splanchnic nerve

(A) Oesophagus Left common carotid artery Left subclavian artery

Left vagus nerve

Arch of aorta

Left recurrent laryngeal nerve Left phrenic nerve

Descending thoracic aorta

(B)

Fig. 3.26 A & B

Left side of the mediastinum.

The azygos vein which receives segmental veins from the thoracic and posterior abdominal walls (intercostal and lumbar veins) joins the superior vena cava.

The phrenic nerves

The right and left phrenic nerves are formed in the cervical plexus (C3, 4, 5). Besides supplying the diaphragm they give sensory innervation to pleura, pericardium and peritoneum (all starting with p!). The thoracic part of the right phrenic nerve (Fig. 3.25) reaches the diaphragm lying on the surface of the right brachiocephalic vein, the superior vena cava, the

right side of the heart and pericardium (where it lies in front of the root of the lung) and the inferior vena cava. In other words it lies on the big veins and the right atrium. The left phrenic nerve crosses the arch of the aorta (Figs 3.26, 3.27). It descends in front of the root of the lung then lies on the pericardium as it descends to reach the diaphragm

The right and left vagus nerves

The right vagus nerve lies on the trachea (Fig. 3.25) and crosses behind the root of the lung and breaks up into

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65

Interior thyroid veins Right brachiocephalic vein Trachea

Brachiocephalic trunk (artery) Left brachiocephalic vein Left subclavian artery Left common carotid artery Left vagus Left recurrent laryngeal nerve

Arch of aorta Superior vena cava Ascending aorta Right phrenic nerve

Pulmonary trunk

Left phrenic nerve Right lung

Heart and pericardium

Fig. 3.27
structures.

Structures in the superior mediastinum seen after removal of the thoracic cage and the parietal pleura. The lungs have been retracted to expose the

branches on the oesophagus forming the oesophageal plexus. It leaves the thorax by passing along with the oesophagus through the diaphragm as the posterior gastric nerve. The left vagus, like the left phrenic nerve, crosses the arch of the aorta (Figs 3.26, 3.27). It crosses behind the root of the left lung (the phrenic nerve descends in front). The left vagus gives off an important branch, the left recurrent laryngeal nerve, as it crosses the arch of the aorta. The left recurrent laryngeal nerve winds round the ligamentum arteriosum, a brous connection between the left pulmonary artery and the arch of the aorta. The ligamentum arteriosum is the remnant of the ductus arteriosum which shunts blood from the pulmonary trunk to the aorta in the fetus. The recurrent laryngeal nerve ascends to the neck lying in the groove between the trachea and the oesophagus and supplies the muscles and mucous membrane of the larynx. Carcinoma of the oesophagus, mediastinal lymph node enlargement and aortic arch aneurysm may compress the left recurrent laryngeal nerve to cause change in voice. Below the root of the lung the left vagus, like the right, breaks up into branches contributing to the oesophageal plexus and leaves the thorax by passing along with the oesophagus through the diaphragm as the anterior gastric nerve.

Clinical box 3.10

Arch of the aorta
The arch of the aorta hooks over the left bronchus and lies on the left side of the trachea and oesophagus with the left recurrent laryngeal nerve lying between the two. An aneurysm of the arch of the aorta can occlude the left bronchus and collapse the left lung. It can produce a change in voice due to compression of the left recurrent laryngeal nerve. Pathology of the aorta, trachea, bronchus and the oesophagus tend to involve one another due to their close relationship. Pulsation of the arch of the aorta is visible during bronchoscopy and oesophagoscopy.

conned to the superior mediastinum. It has three branches: the brachiocephalic trunk which divides into the right common carotid and the right subclavian arteries, the left common carotid artery and the left subclavian artery (Fig. 3.28). The left vagus and the left phrenic nerves cross the arch of the aorta. The small vein lying across the arch of the aorta is the left superior intercostal vein. This drains the second and third left intercostal spaces and in turn drains into the left brachiocephalic vein (Fig. 3.26). See Clinical box 3.10.

Arch of the aorta

The ascending aorta commencing from the left ventricle continues upwards and to the left over the root of the left lung as the arch of the aorta (Figs 3.263.28). It then descends down to become the descending thoracic aorta. The arch of the aorta commences at the level of the sternal angle and ends at the lower border of T4. It is entirely

The trachea
The trachea (Figs 3.29, 3.30) extends from the lower border of the cricoid cartilage in the neck to the tracheal bifurcation at the level of the lower border of the T4 vertebra. In the living, in the erect posture, the tracheal bifurcation is at a lower level. The trachea is about 15cm long, the rst 5cm

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HUMAN ANATOMY

Left common carotid artery Right common carotid artery Right vertebral artery

Left vertebral artery Right common carotid artery Left subclavian artery Right subclavian artery Left common carotid artery Right internal thoracic artery Brachiocephalic trunk

Arch of aorta

Fig. 3.28

Arch aortogram.

Right vagus Right recurrent laryngeal nerve Right vagus Trachea Left vagus

Left recurrent laryngeal nerve Right phrenic nerve

Arch of aorta (cut) Superior vena cava

Left phrenic nerve Ligamentum arteriosum

Ascending aorta

Pulmonary trunk

Tracheal bifurcation

Fig. 3.29
removed.

Superior mediastinum deeper aspect. Part of the arch of the aorta and its branches, the superior vena cava and the brachiocephalic veins have been

being in the neck. The cervical part of the trachea lies in the midline and is easily palpable. The diameter of the lumen of the trachea is correlated to the size of the subject and has approximately the same diameter as his/her index nger. It is made up of 1520 C-shaped cartilaginous rings which prevent it from collapsing. The gap in the cartilage is at the back and is

bridged by the trachealis muscle which allows the trachea to constrict and dilate. It is elastic enabling it to stretch during swallowing and its diameter changes during coughing and sneezing. The thoracic part of the trachea is in the superior mediastinum. Anteriorly it is related to the left brachiocephalic vein, the commencement of the