Xin Guo, PhD, RDN
Department of Toxicology and Nutrition, School of Public Health,
Shandong University, Jinan, Shandong, China, 250012
Email: xguo@sdu.edu.cn
Phone: 0531-88382135
EDUCATION
Ph.D., Nutrition
Texas A&M University, College Station, TX May 2013
M.S., Biochemistry and Molecular Biology
University of Science and Technology of China, Hefei, China June 2007
B.E., Bioengineering
Jiangxi Normal University, Nanchang, China June 2004
EXPERIENCE
Associate Professor, Shandong University, School of Public Health, September 2017-present
Postdoctoral Research Associate, Baylor College of Medicine, Children’s Nutrition Research Center, March 2016-August 2017
Postdoctoral Research Associate, TAMU, Department of Nutrition and Food Science, August 2013 –March 2016
Dietetic internship, TAMU, Department of Nutrition and Food Science, August 2012- May 2013
Rotations: Veteran Affair Hospital (wound care, outpatient, food services), Scott & White Hospital (diagnostic medicine,
endocrinology and pediatric), St Joseph Hospital (oncology, cardiology, CCU, and nutrition support), Liberty
Dialysis, College Station Independent School District, Franklin Independent School District, AgriLife
Extension, TAMU Athletics, and Brazos Valley Women, Infants and Children (WIC).
Graduate Research Assistant, TAMU, Department of Nutrition and Food Science, September 2007-August 2012
Graduate Teaching Instructor and Assistant, TAMU, Department of Nutrition and Food Science, Spring 2009-Spring 2012
Class: NUTR 304 Food Service System & Management
NUTR 210 Horizons in Nutrition and Food Science
NUTR 405 Nutritional Treatment of Disease
NUTR 470 Nutrition and Physiology Chemistry
NUTR 404 Nutrition Assessment and Plan
Graduate Research Assistant, USTC, Department of Life Science, September 2004 – July 2007
CERTIFICATE
Registered Dietitian Nutritionist July 2013
MEMBERSHIP
Academy of Nutrition and Dietetics (AND) since 2011
Chinese Nutrition Society since 2017
FUNDING
1. Shandong University Educational Reform Project, ¥40000, 2019/5-2021/5.
2. National Natural Science Foundation Youth Project, 81803224, ¥210000, 2019/1-2021/12.
3. Future Scholar Program of Shandong University, 2018WLJH33, ¥500000, 2018/7-2023/6.
4. Shandong University Basic Research Project, 2017TB0028, ¥150000, 2017/9-2019/12.
PEER-REVIEWED ARTICLES
1. Luo, X., Li, H., Ma, L., Zhou, J., Guo, X., Woo, SL., Pei, Y., Knight, L., Deveau, M., Chen, Y., Qian, X., Xiao, X., Li, Q.,
Chen, X., Huo, Y., McDaniel, K., Francis, H., Glaser, S., Meng, F., Alpini, G., Wu, C. Expression of STING Is Increased in
Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice.
GASTROENTEROLOGY. 2018,155(6)：1971. DOI: 10.1053/j.gastro.2018.09.010.
2. Suo, J.N., Zhao, XZ., Guo, X.,* Zhao, XL*. Met-enkephalin improves metabolic syndrome in high fat diet challenged mice
through promotion of adipose tissue browning. Toxicology and Applied Pharmacology, 2018. 359: p. 12-23.
3. Guo, X., Shu, C., Zheng, J., Li, H., Pei, Y., Woo, S., Xu, H., Botchlett, R., Qi, T., Guo, T., Zhao, J., Cai, Y., Hu, X., Zhao, Y.,
Huo, Y., Li, P., Wu, C. Cyclic GMP-AMP Ameliorates Diet-induced Metabolic Dysregulation and Regulates
Proinflammatory Responses Distinctly from STING Activation. Scientific Report. 2017, 7(1): 6355.
4. Mo, Q., Salley, J., Roshan, T., Baer, L., May, F., Jaehning, E., Lehing, A., Guo, X., Tong, Q., Nuotio-Antar, A., Shamsi, F.,
Tseng, Y., Stanford, K., Chen, M. Identification and characterization of a supraclavicular brown adipose tissue in mice.
Journal of Clinical Investigation Insight. 2017, 2(11): e93166.
5. Botchlett, R., Woo, S., Liu, M., Pei, Y., Guo, X., Li, H., Wu, C. Nutritional approaches for managing obesity-associated
metabolic diseases. Journal of Endocrinology. 2017, 233 (3) : R145-R171.
6. Botchlett, R., Li, H., Guo, X., Qi, T., Zhao, J., Zheng, J., Woo, S., Pei, Y., Liu, M., Hu, X., Chen, G., Guo, T., Li, Q., Xiao,
X., Huo, Y., and Wu, C. Glucose and Palmitate Differentially Regulate PFKFB3/iPFK2 and Inflammatory Responses in
Mouse Intestinal Epithelial Cells. Scientific Report. 2016, 6 :28963.
7. Guo, T., Woo, S., Guo, X., Li, H., Zheng, J., Botchlett, R., Liu, M., Pei, Y., Xu, H., Cai, Y., Li. X., Li, Q., Xiao, X., Huo, Y.,
and Wu, C. Berberine Ameliorates Hepatic Steatosis and Suppresses Liver and Adipose Tissue Inflammation in Mice with
Diet-induced Obesity. Scientific Report, 2016, 6:22612.
8. Xu, H., Li, H., Woo, S., Kim, S., Shende, V. R., Neuendorff, N., Guo, X., Guo, T., Qi, T., Pei, Y., Zhao, Y., Hu, X., Zhao, J.,
Chen, L., Chen, L., Ji, J., Alaniz, R.C., Earnest, D.J., Wu, C. Myeloid cell-specific disruption of Period 1 and Period 2
exacerbates diet-induced inflammation and insulin resistance. J Biol Chem, 2014; 289 (23): 16374-16388.
9. Xu, Y., An, X., Guo, X., Habtetsion, T., Wang, Y., Xu, X., Kandala, S., Li, Q., Li, H., Zhang, C., Caldwell, R., Fulton, D.,
Su, Y., Hoda, M. N., Zhou, G., Wu, C., Huo, Y. Endothelial PFKFB3 plays a critical role in angiogenesis. ATVB, 2014; 34
(6): 1231-1239.
10. Woo, S., Xu, H., Li, H., Zhao, Y., Hu, X., Zhao, J., Guo, X., Guo, T., Botchlett, R., Qi, T., Huo, Y., Wu, C. Metformin
ameliorates hepatic steatosis and inflammation without altering adipose phenotype in Diet-Induced Obesity. PLoS ONE,
2014; 9 (3), e91111.
11. Chen, Y., Mu, P., He, S., Tang, X., Guo, X., Li, H., Xu, H., Woo, S., Qian, X., Zeng, L., Wu C. Gly482Ser mutation impairs
the effects of peroxisome proliferator–activated receptor γ coactivator-1α on decreasing fat deposition and stimulating
phosphoenolpyruvate carboxykinase expression in hepatocytes. Nutrition Research. 2013; 33 (4): 332-339.
12. Li, H., Guo, X. (co-first author, equal contribution), Xu, H., Woo, S., Halim V., Morgan C., Wu, C. A role for inducible
6-phosphofructo-2-kinase in the control of neuronal glycolysis J Nutr Biochem. 2013; 24 (6): 1153-1158.
13. Guo, X., Li, H., Xu, H., Halim, V., Thomas, L.N., Woo, S., Huo, Y., Chen, Y. U., Sturino, J.M., and Wu, C. Disruption of
inducible 6-phosphofructo-2-kinase impairs the suppressive effect of PPARγ activation on diet-induced intestine
inflammatory response. J Nutr Biochem, 2013; 24 (5): 770-775.
14. Guo, X., Li, H., Xu, H., Woo, S., Dong, H., Lu, F., Lange, A.J., Wu, C. Glycolysis in the control of blood glucose homeostasis
(Invited Review). Acta Pharmaceutica Sincia, 2012; 2:358-367.
15. Guo X., Li H., Xu H., Halim V., Zhang W., Wang H., Ong K.T., Woo S.L., Walzem R.L., Mashek D.G., Dong H., Lu
F., Wei L., Huo Y, and Wu C. Palmitoleate Induces Hepatic Steatosis but Suppresses Liver Inflammatory Response in
Mice. PLoS ONE, 2012; 7:e39286. PMCID: PMC3387145.
16. Huo, Y., Guo, X. (co-first author, equal contribution), Li, H., Xu, H., Halim, V., Zhang, W., Wang, H., Fan, Y., Ong, K.T.,
Woo, S., Chapkin, R.S, Mashek,D.G., Chen, Y., Dong, H., Lu, F., Wei, L., Wu. C. Targeted overexpression of inducible 6-
Phosphofructo-2-kinase in adipose tissue increases fat deposition but protects against diet-induced insulin resistance and
inflammatory response. J Biol Chem, 2012; 287(25): 21492-21500.
17. Zhuang, G.., Meng, C. (co-first author, equal contribution), Guo, X., Xu, H., Wang, G., Li, H., and Wu, C., Zhou, B. A
Novel Regulator of Macrophage Activation miR-223 in Obesity-Associated Adipose Tissue Inflammation. Circulation,
2012; 125(23): 2892–2903.
18. Guo, X., Huo, Y., Xu, K., Li, H., Zhang, W., Wang, H., Zhang, J., Lange, A.J., Chen, Y.E., and Wu, C. Involvement of
inducible 6-phosphofructo-2-kinase in the anti-diabetic effect of rosiglitazone in mice. J Biol Chem, 2010; 285: 23711-
23720.
19. Huo, Y., Guo, X., Li, H., Wang, H., Zhang, W., Wang, Y., Zhou, H., Gao, Z., Telang, S., Chesney, J., Chen, Y.E., Ye, J.,
Chapkin, R.S., and Wu, C. Disruption of inducible 6-phosphofructo-2-kinase ameliorates diet-induced adiposity but
exacerbates systemic insulin resistance and adipose tissue inflammatory response. J Biol Chem, 2010; 285: 3713-3721.
20. Chen, Y.P., Shen, Y.Y., Guo, X. (co-first author, equal contribution), Zhang, C.S., Yang, W.J., Ma, M.L., Liu, S.,
Zhang, M.B., and Wen, L.P. Transdermal protein delivery by a coadministered peptide identified via phage display.
Nature Biotechnology, 2006; 455-460.
