PATHOLOGY – NEOPLASIA
1. A benign epithelial neoplasm producing microscopically or macroscopically visible finger-like
projections from epithelial surfaces.
a. Fibroma
b. Cystadenoma
c. Polyp
d. Papilloma
2. Which one of these cancers does not metastasize?
a. Glioma
b. Leiomyosarcoma
c. Lymphoma
d. fibrosarcoma
3. Which one of these tumors is malignant?
a. Mature teratoma
b. Lymphoma
c. Meningioma
d. osteoma
4. Carcinomas metastasize through lymphatics, whereas sarcomas always metastasize
hematogenously.
a. TRUE
b. FALSE
5. This refers to the parenchymal cells that stimulate the formation of an abundant collagenous
stroma.
a. Desmoplasia
b. Dysplasia
c. Anaplasia
d. neoplasia
6. This refers to tumor implants discontinuous with the primary tumor.
a. Mitosis
b. Invasion
c. Infiltration
d. Metastasis
7. “Desmoplasia” refers to the enzymatic lysis of connective tissue matrix by tumor cells.
a. TRUE
b. FALSE
8. Histologic findings useful for the diagnosis of malignancy include mitotic activity, atypical
nuclei, and invasion of tumor cells.
a. FALSE
b. TRUE
9. Divergent differentiation of a single line of parenchymal cells into another tissue creates
_____.
a. Teratoma
b. Mixed tumor
c. Sarcoma
d. Carcinoma
10. Cushing syndrome is usually seen in ______.
a. Small cell carcinoma of lung
b. Breast carcinoma
c. Squamous cell carcinoma of lung
d. Renal carcinoma
11. This may represent the earliest manifestation of an occult neoplasm.
a. Paraneoplastic syndrome
b. Impingement on adjacent structures
c. Cachexia
d. Lymph node enlargement
12. The orientation of anaplastic cells is markedly disturbed.
a. Dysplasia
b. Loss of polarity
c. Pleomorphism
d. Poorly-differentiated
13. Dermoid cyst is found in the _______.
a. Skin
b. Ovary
c. Breast
d. brain
14. Lack of cell differentiation from normal cells is called _______.
a. Dysplasia
b. Loss of polarity
c. Pleomorphism
d. Anaplasia
15. This agent may cause angiosarcoma of the liver.
a. Ethylene oxide
b. Vinyl chloride
c. Benzene
d. Asbestos
16. Aberrant differentiation may produce a mass of disorganized but mature cells or tissue
indigenous to the particular site.
a. Anaplasia
b. Hamartoma
c. Pleomorphism
d. choristoma
17. A benign tumor of striated muscle tissue.
a. Rhabdomyosarcoma
b. Leiomyosarcoma
c. Rhabdomyoma
d. leiomyoma
18. A malignant tumor of the placental epithelium.
a. Cystadenocarcinoma
b. Choriocarcinoma
c. Hydatidiform mole
d. Embryonal carcinoma
19. Dissemination of cancers may occur through this/these pathway/s:
a. Lymphatics
b. Direct seeding
c. All of these
d. Hematogenous
20. The growth of cancers is accompanied by:
a. Invasion
b. Destruction
c. Infiltration
d. All of these
21. The proportion of cells within the tumor population that are in the proliferative pool is
referred as _______.
a. Growing lesion
b. Growth fraction
c. Replicative pool
d. Doubling time
22. Which of the following is not true of benign tumors?
a. Well-differentiated
b. Well-demarcated
c. Metastasis
d. Expansile growth
23. A benign cartilaginous tumor.
a. Fibroma
b. Chondroma
c. Chondrosarcoma
d. osteoma
24. The terms “benign” and “malignant” denote morphologic rather than biologic characteristic of
tumors.
a. FALSE
b. TRUE
25. Malignant tumor of the totipotential cells in the gonads.
a. Immature teratoma
b. Plemorphic edenoma
c. Mature teratoma
d. Mixed tumor
26. Enlarged lymph nodes in the lymphatic drainage of a tumor often do not contain metastatic
tumor cells.
a. FALSE
b. TRUE
27. Malignant neoplasm of epithelial cell origin.
a. Carcinoma
b. Parenchyma
c. Sarcoma
d. Stroma
28. Nomenclature of benign tumors are classified based on:
a. Cells of origin
b. Macroscopic patterns
c. All of these
d. Microscopic architecture
29. This literally means disordered growth.
a. Dysplasia
b. Hamartoma
c. Giant cell
d. Anaplasia
30. Carcinoid syndrome is usually seen in ____.
a. Hepatocellular carcinoma
b. Bronchial adenoma
c. Ovarian carcinoma
d. Fibrosarcoma
31. Benign tumors may be fatal.
a. FALSE
b. TRUE
32. Staging of cancers is based on:
a. Extent of spread
b. Presence or absence of metastasis
c. All of these
d. Size of the tumor
33. Laboratory diagnosis of cancer include:
a. All of these
b. Immunohistochemistry
c. Histologic methods
d. Molecular diagnosis
34. A malignant neoplasm that produces a macroscopically visible projection above a mucosal
surface.
a. Polypoid
b. Papilloma
c. Fibroma
d. Polyp
35. The enlargement of nodes in patients with cancer may be caused by:
a. Reactive hyperplasia
b. All of these
c. Growth of cancer cells
d. Spread of cancer cells
36. This refers to the extent of which neoplastic cells resemble comparable normal cells.
a. Pleomorphism
b. Anaplasia
c. Dysplasia
d. Differentiation
37. Which of the following is not ture of neoplasia
a. Autonomous proliferation
b. Uncoordinated growth
c. Abnormal mass of tissue
d. All are cancers
38. The most common pathway for the initial dissemination of carcinomas.
a. Direct invasion
b. Direct seeding
c. Hematogenous
d. Lymphatics
39. The normal nucleus-to-cytoplasm ratio.
a. 1:8
b. 1:10
c. 1:4
d. 1:1
40. Anaplastic tumors show considerable cellular atypia & nuclear pleomorphism and do not
resemble their tissue of origin.
a. TRUE
b. FALSE
41. The most common pathway for the initial dissemination of sarcomas.
a. Hematogenous
b. Lymphatics
c. Direct invasion
d. Direct seeding
42. A neoplasm made up a variety of parenchymal cells types representative of more than one
germ layer.
a. Mixed tumor
b. Carcinoma
c. Sarcoma
d. Teratoma
43. An ectopic rest of normal tissue.
a. Teratoma
b. Hamartoma
c. Chondroma
d. Choristoma
44. Tissues that can be identified in teratoma include:
a. Skin
b. Tooth
c. All of these
d. Fat
45. The most reliable feature that differentiates malignant from benign tumors.
a. Destruction
b. Invasion
c. Infiltration
d. Metastasis
46. Variation in size and shape of both the calls and the nuclei.
a. Pleomorphism
b. Loss of polarity
c. Anaplasia
d. Differentiation
47. Benign tumors that originate from epithelium are called “epitheliomas,” “adenomas” or
papillomas”.
a. TRUE
b. FALSE
48. The occurrence of pain differentiates tumors from benign ones.
a. TRUE
b. FALSE
49. Malignant tumors may be histologically indistinguishable from benign neoplasm.
a. TRUE
b. FALSE
50. Malignant tumor arising in mesenchymal tissue.
a. Stroma
b. Carcinoma
c. Sarcoma
d. Parenchyma
QUIZ
1. Tumors are said to be clonal.
a. FALSE
b. TRUE
2. Seminomas are benign tumor of the testis.
a. FALSE
b. TRUE
3. Dysplastic cells always progress to cancer.
a. TRUE
b. FALSE
4. The presence of mitosis indicates that a tumor is malignant.
a. FALSE
b. TRUE
5. Mixed tumors are composed of cells representative of a single germ layer.
a. TRUE
b. FALSE
6. The grading of malignant tumors is based on histologic examination, whereas staging requires a
clinical assessment of the extent of tumor spread.
a. FALSE
b. TRUE
7. Cachexia is caused by the functional activity of cancer cells such as hormone synthesis.
a. FALSE
b. TRUE
8. Hepatomas are carcinoma of the liver.
a. TRUE
b. FALSE
9. Benign tumors do not have the capacity of infiltrate or invade
a. FALSE
b. TRUE
10. Invasiveness is the most reliable feature that differentiates malignant from benign tumors.
a.FALSE
b.TRUE
