STROKE
Acute, focal, neurological deficit caused by ischaemia
Focal Not global
o E.g. you won’t have global deficits
Types of stroke
Ischaemic (80%)
o Blood
Thrombus
Embolus
Haemorrhagic (20%)
o Blood (outside)
Aneurysm (5%)
Intracranial haemorrhage (HT!!!) – (15%)
Pathology
Atherosclerosis (main with ischaemic attack)
o Risk factors
Modifiable
HT
Diabetes
Hypercholesterolemia
Lack of exercise
Increased weight
Smoking
Unmodifiable
Age
Gender
Haemorrhage
Features
o Raised ICP
Papilledema
Progressive decreased LOC
Intense headache
Vomiting
o Cushing reflex BP
NB Haemorrhagic vs. Ischaemia NEED CT to determine if haemorrhage (not for Dx)
Warning signs of stroke
1. Motor loss
a. Acute unilateral
i. Face, arm & leg
2. Sensory loss
a. Unilateral
3. Speech
a. Something acutely wrong with speech
4. Vision
a. Unilateral anopia or hemianopia
5. Loss of balance (acute)
6. Acute intense headache
Examination (FAST)
Face (smile)
Arm Keep up for 10 seconds
Speech Repetition
Time
Immediate management
Thrombolytic (TPA)
o Window period of 4 ½ hours to give thrombolytic
After this time the vascular beds will be too damaged and there will
be a risk of inducing bleeding to the brain when clot is lysed
Aspirin (at any time)
Treatment
NB When did it start!
1. TPA 0.9mg/kg Most effective
a. Criteria for thrombolytic (NB)
i. Stroke
ii. 4 ½ hours
iii. CT to exclude haemorrhage
iv. 18‐80 years
v. NIH stroke score >4 and < 23
2. Aspirin
a. Can be given even if there is haemorrhage
3. Stroke unit
Transient Ischaemic Attack (TIA)
Looks like a stroke but clears up within 24 hours
70‐80% of cases only last 10 seconds
Clot breaks up and does not obstruct vessel
o NB Same underlying pathology as stroke (same origin)
o risk of developing stroke in the future
Treatment
Aspirin 300mg
Simvastatin 40mg
ACE inhibitor
Secondary prevention of stroke ABCD!
A. Antiplatelet (All TIA/Strokes) & Anticoagulant (cardiac reasons)
B. BP medication
C. Cholesterol (Statin) & Carotid end arterectomy (if stenosis > 70%)
D. Diabetes