ORIENTAL COLLEGE OF PHARMACY AND RESEARCH

ORIENTAL UNIVERSITY, INDORE

COURSE FILE

Semester-B Pharm III Semester

Subject- Pharmaceutical Engineering
Session: July-Dec,22
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Faculty Details:
Name of the Faculty Member/s Ms. Nikita Kale
Designation Assistant Professor
Department Oriental College of Pharmacy and Research
Faculty Faculty of Pharmacy

Course Details:
Name of the Programme B. Pharm. Batch 2021-25

Branch Pharmacy Semester III

Pharmaceutical
Course Name Course Code BP 304 T/ BP308P.
Engineering-I
Course Credit 3-1-4 No. of Students 100

(i) Pre-requisites : Basic knowledge of Pharmaceutics Engineering-I

(ii) Co-requisites : Various unit operations used in pharmaceutical industry
Date of Approval :

Vision and Mission of the Department:

To nurture global leader in Pharmacy Profession committed to provide a transformative learning
experience in a collaborative and diverse environment focused on improving the health care
system to serve the community.

Mission of the Department:

 To provide and continuously upgrade the infrastructure, state-of-the–art technology and
training for the students and faculty.
 To encourage high quality research in drug discovery in collaboration with industries.
 To impart and implement academia-industry collaboration for upgrading pharmacy
students and faculties.
 Our main focus is to create bridge in between academia-industry to make our students
globally competent.
 To implement modern pedagogical methods in class room and laboratories for improving
teaching and learning process.
 To inculcate and maintain national and international level of excellence in under
graduate, post graduate and research programs.
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Program Education Objectives(PEOs):

PEO01 Knowledge: To produce pharmacy graduates with strong basics and high technical
knowledge to cater the various areas of Pharmaceutical industry. Graduates of the program
will assimilate theoretical knowledge along with necessary practical skill sets of
pharmaceutical sciences and able to use these tools in Pharmaceutical industry, hospitals
and institutes or where ever in the area of profession they choose necessary for success.
PEO02 Core Competence: To cater perfect blend of fundamentals principles in subjects like
Pharmaceutics, Pharmaceutical Chemistry, Pharmacology, Pharmacognosy and
Pharmaceutical analysis as per the requirement of Pharmaceutical Industries, Community
and Hospital Pharmacy. The Program aims to develop students competent for future.
PEO03 Training: The ideology of the institute is to train graduates to excel in higher studies in
India and abroad and also to succeed in Pharmaceutical commercial sector or in the
profession wherever the student chose through innovative teaching methodologies that
engage students in self-learning. To provide Pharmacists to the society with skill and will
to make and serve quality pills.
PEO04 Assessment: Graduates of the program will be able to assess advantages and is advantages,
pros and cons, benefits and deficiencies, strength and weaknesses of the matter they studied
in Pharmaceutical Technology they learned and ideology they observed in the field of
Pharmaceutical sciences.
Program Outcomes(POs):

PO0 Basic Knowledge:The graduate will be able to understand the strong fundamental concepts
1 and develop an ability to identify, formulate the pharmaceutical products by adopting the
appropriate skills. Graduate should elevate advance knowledge and professional skills by
participating in programs of Oriental University Indore.
PO0 Ethics:A graduate will follow a code of ethics of Pharmacy Council of India with respectto
2 community service. Also a graduate student is able to learn and apply the quality
assuranceprinciplesin regulatoryand ethical aspectsfrom a courseofQuality
AssuranceTechniques.
PO0 Problem Analysis:A Graduate will be able to utilize the principles of scientific
3 enquiry,thinking analytically, clearly and critically, while solving problems and making
decisions duringdaily practice. They will be able to Find, analyze, evaluate and apply
information systematicallyandshall makedefensibledecisions.
PO0 Interpersonal and Communication Skills:A graduate will adopt effective
4 interpersonalwritten and verbal skills, also able to effectively educate community, patients
and Health CareProfessionals.They willalsobe able tomake effective presentationsand
documentation, andgive and receiveclear instructions.
PO0 Research Activity:A Graduate is also actively involved in various research activities
5 withimportantphasesofdrugsynthesis,manufacturingofpharmaceuticalsandformulationdevelo
pment.
PO0 Practice Based Learning:A graduate should be able to demonstrate skills necessary
6 forpracticeofaPharmacy,ableto synthesize,purify,identifyandanalyzemedicinal agents,ableto
formulate, store, dispense, manufacture the pharmaceutical products and analyze
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theprescription. Establish self assessmentskills, and made a commitment to the lifelong

learningrequired and incorporate knowledge from scientific information to enhance the
quality ofpharmacyprofession andotherhealth care relatedservices.

Program Specific Outcomes(PSOs):

PSO01 Impart Knowledge To prepare a graduate to develop and characterize different
pharmaceutical dosageforms.Also performprocess validationforproductionof
suchpharmaceutical formulations.
PSO02 Technical aspect in Industry
Topreparegraduatetosuccessintechnicalorprofessionalcareersinvariouspharmaceutical
industry and/ or institute and /or Health care system through excellent real timeexposureto
rigorouseducation.
PSO03 Skill Development To strengthenthe professional andethical attitude,
effectivecommunication skills,teamwork skills, multidisciplinary approach, and an ability
to relate pharmaceutical sciencesissuesto broader social context.
PSO04 Quality Maintenance Graduate will be able to recognize various applications of
pharmacy and pharmaceuticalscience indrug discovery anddevelopment,formulationstudy,
quality assurance andpostmarketingsurveyrelatedto finishedproducts.
PSO05 Professional Growth Streams a lifelong career of personal and practicing professional
growth with ethicalcodesandselfesteem.
PSO06 Research Orientation Graduate will be able to perform research on various medical
aspects and implement the Pharmaceutical knowledge in formulating the best suitable
dosage form to provide high quality medicines to the society.

Course Learning Objectives(CLOs):

CLO01 To know various unit operations used in Pharmaceutical industries
CLO02 To understand the material handling techniques
CLO03 To perform various processes involved in pharmaceutical manufacturing process

CLO04 To carry out various test to prevent environmental pollution.

CLO05 To appreciate and comprehend significance of plant lay out design for optimum use of
resources

Course Outcomes (COs):

After completion of this course the students shall be able to:
CO01 Understand to size reduction, factors affecting size reduction, basic principles.
CO02 Understand to objectives, applications & Heat transfer mechanisms.
CO03 Understand to objectives, applications & factors affecting mixing
CO04 Understand to factors influencing filtration, filter aids, filter medias
CO05 Understand to Factors affecting during materials selected for Pharmaceutical plant.
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CO-PO Mapping:

Programme
Outcomes
PO01 PO02 PO03 PO04 PO05 PO06
Course
Outcome
CO01 3 3 2 2
CO02 3 3 2
CO03 3 3 2 2
CO04 3 3 2 2
CO05 3 3 2

Indicate 3, 2 or 1
3 = Significant, 2 = Medium Significance, 1 = Low Significance

CO-PSO Mapping:

Programme
Specific
Outcomes PSO01 PSO02 PSO03 PSO04 PSO05 PSO06
Course
Outcome
CO01 3 2 3 2 3
CO02 1 3 2 3 2 3
CO03 1 3 2 3 2 3
CO04 1 3 2 3 2 3
CO05 3 2 3 2 3
Indicate 3, 2 or 1
3 = Significant, 2 = Medium Significance, 1 = Low Significance
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Course Syllabus
UNIT-I 10
Hours
 Flow of fluids: Types of manometers, Reynolds number and its significance, Bernoulli’s
theorem and its applications, Energy losses, Orifice meter, Venturimeter, Pitot tube and
Rotometer.
 Size Reduction: Objectives, Mechanisms & Laws governing size reduction, factors
affecting size reduction, principles, construction, working, uses, merits and demerits of
Hammer mill, ball mill, fluid energy mill, Edge runner mill & end runner mill.
 Size Separation: Objectives, applications & mechanism of size separation, official
standards of powders, sieves, size separation Principles, construction, working, uses,
merits and demerits of Sieve shaker, cyclone separator, Air separator, Bag filter &
elutriation tank.
UNIT-II 10
Hours
 Heat Transfer: Objectives, applications & Heat transfer mechanisms. Fourier’s law,
Heat transfer by conduction, convection & radiation. Heat interchangers & heat
exchangers.
 Evaporation: Objectives, applications and factors influencing evaporation, differences
between evaporation and other heat process. principles, construction, working, uses,
merits and demerits of Steam jacketed kettle, horizontal tube evaporator, climbing film
evaporator, forced circulation evaporator, multiple effect evaporator& Economy of
multiple effect evaporator.
 Distillation: Basic Principles and methodology of simple distillation,flash distillation,
fractional distillation, distillation under reduced pressure, steam distillation & molecular
distillation
UNIT- III 08
Hours
 Drying: Objectives, applications & mechanism of drying process, measurements &
applications of Equilibrium Moisture content, rate of drying curve. principles,
construction, working, uses, merits and demerits of Tray dryer, drum dryer spray dryer,
fluidized bed dryer, vacuum dryer, freeze dryer.
 Mixing: Objectives, applications & factors affecting mixing, Difference between solid
and liquid mixing, mechanism of solid mixing, liquids mixing and semisolids mixing.
Principles, Construction, Working, uses, Merits and Demerits of Double cone blender,
twin shell blender, ribbon blender, Sigma blade mixer, planetary mixers, Propellers,
Turbines, Paddles & Silverson Emulsifier,
UNIT-IV 08
Hours
 Filtration: Objectives, applications, Theories & Factors influencing filtration, filter aids,
filter medias. Principle, Construction, Working, Uses, Merits and demerits of plate &
frame filter, filter leaf, rotary drum filter, Meta filter & Cartridge filter, membrane filters
and Seidtz filter.
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 Centrifugation: Objectives, principle & applications of Centrifugation, principles,

construction, working, uses, merits and demerits of Perforated basket centrifuge, Non-
perforated basket centrifuge, semi continuous centrifuge & super centrifuge.

UNIT- V 07
Hours
 Materials of pharmaceutical plant construction, Corrosion and its prevention:
Factors affecting during materials selected for Pharmaceutical plant construction,
Theories of corrosion, types of corrosion and there prevention. Ferrous and nonferrous
metals, inorganic and organic non metals, basic of material handling systems.

BP308P - PHARMACEUTICAL ENGINEERING (Practical)

4Hours/week
1. Determination of radiation constant of brass, iron, unpainted and painted glass.
2. Steam distillation – To calculate the efficiency of steam distillation.
3. To determine the overall heat transfer coefficient by heat exchanger.
4. Construction of drying curves (for calcium carbonate and starch).
5. Determination of moisture content and loss on drying.
6. Determination of humidity of air – i) From wet and dry bulb temperatures –use of Dew
point method.
7. Description of Construction working and application of Pharmaceutical Machinery such
as rotary tablet machine, fluidized bed coater, fluid energy mill, de humidifier.
8. Size analysis by sieving – To evaluate size distribution of tablet granulations –
Construction of various size frequency curves including arithmetic andlogarithmic
probability plots.
9. Size reduction: To verify the laws of size reduction using ball mill and determining
Kicks, Rittinger’s, Bond’s coefficients, power requirement and critical speed of Ball Mill.
10. Demonstration of colloid mill, planetary mixer, fluidized bed dryer, freeze dryer and such
othermajor equipment.
11. Factors affecting Rate of Filtration and Evaporation (Surface area, Concentration and
Thickness/ viscosity
12. To study the effect of time on the Rate of Crystallization.
13. To calculate the uniformity Index for given sample by using Double Cone Blender.

Reference Books
1. Introduction to chemical engineering – Walter L Badger & Julius Banchero, Latest
edition.
2. Solid phase extraction, Principles, techniques and applications by Nigel J.K. Simpson-
Latest edition.
3. Unit operation of chemical engineering – Mcabe Smith, Latest edition.
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4. Pharmaceutical engineering principles and practices – C.V.S Subrahmanyam et al.,

Latest edition.
5. Remington practice of pharmacy- Martin, Latest edition.
6. Theory and practice of industrial pharmacy by Lachmann., Latest edition.
7. Physical pharmaceutics- C.V.S Subrahmanyam et al., Latest edition.
8. Cooper and Gunn’s Tutorial pharmacy, S.J. Carter, Latest edition.

Method of Evaluation used:

 Class Test (Assessment I, Assessment II and Assessment III)√
 Assignments √
 Term End Examination√
 Quiz√
 Attendance √
 Mini Projects ×
 Viva-Voce & Lab FileEvaluation (After completion of each experiment)√
 Seminar/Presentation√
 Role Play ×
 Conduct ×

Content Covered Beyond Syllabi and Action Taken (if applicable)

Sr. Topic to be covered Need for PO *Efforts Date of

No. the topic addressed undertake conduction
n
1
2

*Note: Efforts indicate lecture taken by faculty like guest lecture, seminar, workshop, visits etc.
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9:55 - 5- 10:50 - 30 - 01:20- 02:20- 03:20 -
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P’ P’ceutical Organic Chemistry II –

Physical Organic
Microbiolog Practical Batch A(NK)
A P'ceutics-I Chemistry-II PD Classes
y (PU) Physical Pharmaceutics I – Practical
Monday

(NS) (NK)
Tutorial Batch B (NS)
Pharmaceutical Microbiology –
Organic Physical P’
Practical Batch A (PU)
B Chemistry-II PD Classes P'ceutics-I Microbiology
Pharmaceutical Engineering –
(NK) (NS) (PU) Tutorial
Practical Batch B (NK)
P’ceutical Organic Chemistry II –
P’ P’ Organic
Practical Batch B(NK)
A Microbiology PD Classes Engineering Chemistry-II
Physical Pharmaceutics I – Practical
Tuesday

(PU) (NK) (NK)

Batch A (NS)
Pharmaceutical Microbiology –
P’ Organic P’
Practical Batch B (PU)
B Engineering Chemistry-II Microbiology PD Classes
Pharmaceutical Engineering –
(NK) (NK) (PU)
Practical Batch A (NK)
Pharmaceutical Microbiology –
P’ Organic Physical
Practical Batch A (PU)
A Microbiology Chemistry-II P'ceutics-I
Wednesday

Pharmaceutical Engineering –
(PU) Mentor- (NK) Tutorial (NS)
Practical Batch B (NK)
Mentee
P’ Organic Chemistry II – Practical
Organic Interaction Physical Pharmaceutica LU
BRE Batch A (KD)
B Chemistry-II P'ceutics-I l Microbiology NC
AK Physical Pharmaceutics I – Practical
(NK) (NS) Tutorial (PU) H Batch B (NS)
Pharmaceutical Microbiology –
Physical P’ Organic
P’ Engineering Practical Batch B (PU)
A P'ceutics-I Microbiolog Chemistry-II
(NK) Tutorial Pharmaceutical Engineering –
Thursday

(NS) Tutorial y (PU) (NK)

Practical Batch A (NK)
P’ P’ceutical Organic Chemistry II –
Organic Physical P’
Engineering Practical Batch B (KD)
B Chemistry-II P'ceutics-I Microbiology
(NK) Physical Pharmaceutics I – Practical
(NK) (NS) (PU)
Tutorial Batch A (NS)
Physical P’
A P'ceutics-I Remedial/ Engineering Remedial/ Pharmace
Physical
Friday

(NS) Quiz P’ (NK) Quiz Organic utical

P'ceutics Library
P’ Microbiolog Physical Chemistry-II Microbiol
-I (NS)
B Engineering y (PU) P'ceutics-I (NK) ogy (PU)
(NK) (NS)
P’
A Engineering Remedial/ Remedial/
Saturday

(NK) Quiz Quiz

Physical P’ Library Library Sports
P’
P’ceutics-I Engineering
B Engineering
(NS) (NK)
(NK)

TG/MENTOR - MS. NIKITA SHAHARE

Classes Third floor Section A – T 9; Section B – T 10

NK- Dr. Neelam Khan; NS – Ms. Nikita Shahare; NK – Ms. Nikita Kale; PU –
Ms. Prachi Upadhayay
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Course Schedule (Theory)

Course Code: BP 304 T Course Name: Pharmaceutical Engineering -I

Teaching scheme: Lectures: _4 Hrs/week, Tutorials: _1 Hr/week, Practicals:_4 Hr/week
Examination scheme: Theory
In-Semester Assessment:25 Marks
End-Semester Assessment:75 Marks

CO Description Blooms Level

CO1 Understand to size reduction, factors affecting size reduction, basic BL01
principles.
CO2 Understand to objectives, applications & Heat transfer mechanisms. BL02
CO3 Understand to objectives, applications & factors affecting mixing. BL03
CO4 Understand to factors influencing filtration, filter aids, filter medias. BL04
Understand to Factors affecting during materials selected for BL05
CO5
Pharmaceutical plant.

Lecture Plan

S. Proposed Actual Unit Topics Learning CO Reference (Text

No. Date Date of Methodology Books, Journals)
Completio
n
1 1 Flow of fluids: PPT CO01 T1,T2,T3,R1,R2
Types of
manometers
2 Reynolds number PPT CO01 T1,T2,T3,R1,R2
and its
significance,
Bernoulli’s
theorem and its
applications
3 Energy losses, PPT CO01 T1,T2,T3,R1,R2
Orifice meter
4 Venturimeter, PPT CO01 T1,T2,T3,R1,R2
Pitot tube and
Rotometer.

5 Size Reduction: PPT CO01 T1,T2,T3,R1,R2

Objectives,
Mechanisms
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6 Laws governing PPT CO01 T1,T2,T3,R1,R2

size reduction,
factors affecting
size
7 principles, PPT CO01 T1,T2,T3,R1,R2
construction,
working, uses,
merits
8 demerits of PPT CO01 T1,T2,T3,R1,R2
Hammer mill,
ball mill
9 fluid energy mill, PPT CO01 T1,T2,T3,R1,R2
Edge runner mill
& end runner
mill.

10 Size Separation: PPT CO01 T1,T2,T3,R1,R2

Objectives,
applications
11 mechanism of PPT CO01 T1,T2,T3,R1,R2
size separation,
official
standards of
powders
12 sieves, size PPT CO01 T1,T2,T3,R1,R2
separation
Principles,
construction
13 working, uses, PPT CO01 T1,T2,T3,R1,R2
merits and
demerits of Sieve
shaker
14 cyclone PPT CO01 T1,T2,T3,R1,R2
separator, Air
separator, Bag
filter &
elutriation tank.

15 2. Heat Transfer: Classroom CO02 T1,T2,T3,R1,R2

Objectives, Teaching
applications &
Heat transfer
mechanisms
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16 Fourier’s law, Classroom CO02 T1,T2,T3,R1,R2

Heat transfer by Teaching
conduction,
convection &
radiation.
17 Heat Classroom CO02 T1,T2,T3,R1,R2
interchangers & Teaching
heat exchangers.

18 Evaporation: PPT CO02 T1,T2,T3,R1,R2

Objectives,
applications and
factors
influencing
evaporation
19 differences PPT CO02 T1,T2,T3,R1,R2
between
evaporation and
other heat
process
20 principles, PPT CO02 T1,T2,T3,R1,R2
construction,
working, uses
21 merits and PPT CO02 T1,T2,T3,R1,R2
demerits of
Steam jacketed
kettle
22 horizontal tube PPT CO02 T1,T2,T3,R1,R2
evaporator,
climbing film
evaporator
23 multiple effect PPT CO02 T1,T2,T3,R1,R2
evaporator&
Economy of
multiple effect
evaporator.

24 Distillation: PPT CO02 T1,T2,T3,R1,R2

Basic Principles
and methodology
of simple
distillation
25 flash distillation, PPT CO02 T1,T2,T3,R1,R2
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fractional
distillation,
distillation under
reduced pressure
26 steam distillation PPT CO02 T1,T2,T3,R1,R2
& molecular
distillation

27 3. Drying: PPT CO03 T1,T2,T3,R1,R2

Objectives,
applications &
mechanism of
drying process
28 measurements & PPT CO03 T1,T2,T3,R1,R2
applications of
Equilibrium
Moisture content
29 rate of drying PPT CO03 T1,T2,T3,R1,R2
curve. principles,
construction,
working, uses
30 merits and PPT CO03 T1,T2,T3,R1,R2
demerits of Tray
dryer, drum dryer
spray dryer,
31 fluidized bed PPT CO03 T1,T2,T3,R1,R2
dryer, vacuum
dryer, freeze
dryer.

32 Mixing: Classroom CO03 T1,T2,T3,R1,R2

Objectives, Teaching
applications &
factors affecting
mixing
33 Difference Classroom CO03 T1,T2,T3,R1,R2
between solid Teaching
and liquid
mixing,
mechanism of
solid mixing
34 liquids mixing Classroom CO03 T1,T2,T3,R1,R2
and semisolids Teaching
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mixing
35 Principles, Classroom CO03 T1,T2,T3,R1,R2
Construction, Teaching
Working, uses,
Merits and
Demerits of
Double cone
blender,
36 twin shell Classroom CO03 T1,T2,T3,R1,R2
blender, ribbon Teaching
blender, Sigma
blade mixer
37 planetary mixers, Classroom CO03 T1,T2,T3,R1,R2
Propellers, Teaching
Turbines,
Paddles &
Silverson
Emulsifier
38 4 Filtration: Classroom CO04 T1,T2,T3,R1,R2
Objectives, Teaching
applications,
Theories
39 Factors Classroom CO04 T1,T2,T3,R1,R2
influencing Teaching
filtration, filter
aids
40 filter medias. Classroom CO04 T1,T2,T3,R1,R2
Principle. Teaching
41 Construction, Classroom CO04 T1,T2,T3,R1,R2
Working, Uses Teaching
42 Merits and Classroom CO04 T1,T2,T3,R1,R2
demerits of plate Teaching
& frame filter
43 filter leaf, rotary Classroom CO04 T1,T2,T3,R1,R2
drum filter Teaching
44 Meta filter & Classroom CO04 T1,T2,T3,R1,R2
Cartridge filter. Teaching
45 membrane filters Classroom CO04 T1,T2,T3,R1,R2
and Seidtz filter Teaching
46 Centrifugation: Classroom CO04 T1,T2,T3,R1,R2
Objectives, Teaching
principle
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47 applications of Classroom CO04 T1,T2,T3,R1,R2

Centrifugation Teaching
48 principles, Classroom CO04 T1,T2,T3,R1,R2
construction, Teaching
working, uses
49 merits and Classroom CO04 T1,T2,T3,R1,R2
demerits of Teaching
Perforated basket
centrifuge
50 Non-perforated Classroom CO04 T1,T2,T3,R1,R2
basket centrifuge Teaching
51 semi continuous Classroom CO04 T1,T2,T3,R1,R2
centrifuge & Teaching
super centrifuge.

52 5 Materials of Classroom CO05 T1,T2,T3,R1,R2

pharmaceutical Teaching
plant
construction,
Corrosion and its
prevention
53 Factors affecting Classroom CO05 T1,T2,T3,R1,R2
during materials Teaching
54 Pharmaceutical Classroom CO05 T1,T2,T3,R1,R2
plant Teaching
construction
55 Theories of Classroom CO05 T1,T2,T3,R1,R2
corrosion, types Teaching
of corrosion
56 types of Classroom CO05 T1,T2,T3,R1,R2
corrosion and Teaching
there prevention
57 Ferrous and Classroom CO05 T1,T2,T3,R1,R2
nonferrous Teaching
metals
58 inorganic and Classroom CO05 CO05T1,T2,T3,R1,
organic non Teaching R2
metals
59 basic of material Classroom CO05 T1,T2,T3,R1,R2
handling systems Teaching
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Assignment/Quiz:

Assign/Quiz 1 Assign/Quiz 2 Assign/Quiz 3 Assign/Quiz 4

Date of
Assigning
Date of
Submission

Course Schedule (Practical)

Name of Faculty: Ms. Nikita Kale of Staff:

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Course Code: BP308P Course Name: Pharmaceutical Engineering

Teaching scheme: Lab: 4 Hrs/week
Examination scheme:
In-Semester Assessment:15Marks
End-Semester Assessment:35 Marks

Exp Objective of the Experiment Teaching Conduction Submission

.No. Methodology Date Date
1 Determination of radiation constant of brass, Technical
iron, unpainted and painted glass.
2 Steam distillation – To calculate the efficiency Technical
of steam distillation
3 To determine the overall heat transfer Technical
coefficient by heat exchanger.

4 Construction of drying curves (for calcium Technical

carbonate and starch).

5 Determination of moisture content and loss on Technical

drying.
6 Determination of humidity of air – i) From wet Technical
and dry bulb temperatures –use of Dew point
method
7 Description of Construction working and Technical
application of Pharmaceutical Machinery such
as rotary tablet machine, fluidized bed coater,
fluid energy mill, de humidifier.

8 Size analysis by sieving – To evaluate size Technical

distribution of tablet granulations-Construction
of various size frequency curves including
arithmetic andlogarithmic probability plots.

9 Size reduction: To verify the laws of size Technical

reduction using ball mill and determining
Kicks, Rittinger’s, Bond’s coefficients, power
requirement and critical speed of Ball Mill.

10 Demonstration of colloid mill, planetary mixer, Technical

fluidized bed dryer, freeze dryer and such other
major equipment.

11 Factors affecting Rate of Filtration and Technical

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Evaporation (Surface area, Concentration and

Thickness/ viscosity

12 To study the effect of time on the Rate of Technical

Crystallization.

13 To calculate the uniformity Index for given Technical

sample by using Double Cone Blender.

Reference Questions
S.No Q.1 Question

1. 1. What is the use of a pitot tube? Write its advantages and disadvantages
2. 2. Explain the term ‘head’. List the different heads in the Bernoulli’sTheorem.
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What is Reynolds number? Describe its importance .

3. 3.
4. 4. List the advantages and disadvantages of rotameter
How are losses of energy due to enlargement in cross section measured?Give
5. 5. relevant equation and explain the terms.
Give Reynolds number and explain the symbols used therein.
6. 6.
What is pressure head? How it iscalculated?
7. 7.
Why is mercury used as a liquid in manometer?
8. 8.
Differentiate constant pressure and constant area meters. Give Examples Of
9. 9. devices under each category
Describe the types of flow patterns exhibited by liquids in motion.
10. 10.
Mention the equipment used for solid-solid mixing.
11. 11.
List the equipment used for powder mixing in pharmaceutical industry.
12. 12.
13. 13. Explain flow patterns of impellers
Enumerate the mechanisms of solids mixing.
14. 14.
Describe the mechanisms of liquid mixing. .
15. 15.
16. 16. Enumerate the applications of liquid mixing
17. 17. Classify liquids based on their miscibility. Give one example in eachCase. .
Define and differentiate mixing and agitation.
18. 18.
19. 19. Describe the equipment for solid-solid mixing of pharmaceuticalMaterials..

Explain the factors influencing mixing of solids. Write the principle of planteraty
mixer
20. 20.

21. 21. Write the uses of the sigma blade blender.

22. 22. Explain the construction and working of a ribbon blender for mixingSolids.
Explain the working of a mixer used for mixing dry powders beforeGranulation.
23. 23.
24. 24. Explain the term Evaporator capacity
Define evaporation in terms of capacity and economy as applied to Evaporation
practice.
25. 25.
What is calandria? Give its uses.
26. 26.
What is calandria? Write its importance.
27. 27.
 Session: 2022-23
ORIENTAL UNIVERSITY, INDORE July-Dec, 2022

COURSE FILE SEM: odd

What are the different modes of feed in multiple effect evaporator?

28. 28.
What are the criteria in selecting the metals for the construction of steam
Jacketed kettle?
29. 29.
Write the importance of forced circulation in forced circulationEvaporator.
30. 30.
31. 31. How is multiple effect evaporator advantageous over single effectEvaporator?
Describe the types of condensation for saturated vapour free from non
condensable gases.
32. 32.
33. 33. Define Black body and Grey body.
Give characteristics of drop wise and film types condensation.
34. 34.
Distinguish drying and evaporation.
35. 35.
Define critical moisture content and equilibrium moisture constant.
36. 36.
Explain the importance of drying in the pharma industry with examples.
37. 37.
38. 38. Define bound water and free moisture content.
Name the materials commonly used in packing of fractionating columns.
39. 39.
Differentiate between plate towers and packed towers.
40. 40.
Distinguish evaporation and distillation.
41. 41.
Distinguish between plate column and packed towers. Describe thetypes of
42. 42. packing for rectifying columns.
43. 43. List the factors influencing the rate of filtration.
44. 44. Write Kozeny-Carman equation and give its significance.
45. 45. Give the principle of filtration aids.
Distinguish filtration and clarification.
46. 46.
What is the mechanism of filtration in membrane filter? What are its Advantages
and disadvantages of membrane filters?
47. 47.
Give the neat labelled diagram of pressure sand filter. What are itsUses?
48. 48.
What is meant by back washing? How is it achieved in filtration?
49. 49.
Write two pharmaceutical applications of centrifugation.
50. 50.
Write the applications of perforated basket centrifuges.
51. 51.
Differentiate between sedimentation centrifuges and filtration centrifuges.
52. 52.
 Session: 2022-23
ORIENTAL UNIVERSITY, INDORE July-Dec, 2022

COURSE FILE SEM: odd

Classify industrial centrifuges. Write construction and working of a perforated

basket centrifuges.
53. 53.
54. 54. Give five pharmaceutical application of centrifugal separations.
Write the applications of glass as materials of construction in the Pharmaceutical
industry.
55. 55.
Enumerate the types of glass. Mention an example of formulation that isStored in
56. 56. each type of container
Write the advantages and disadvantages of plastic as packagingMaterial.
57. 57.
Write the uses of rubber as a packaging material.
58. 58.
59. 59. Describe various types of iron as materials of construction.
Classify the materials of Construction. Explain the uses of ferrousmetals.
60. 60.

Expert lecture record (if any)

Industrial Visit Organized (if any)
Overall Course Outcome Attainment and Analysis (at the end of the semester after result
declaration)
Annexure to be added
a) Academic calendar
b) Class time table
c) Attendance register
d) Internal assessment (result)
e) Remedial classes record (notice, time table and attendance)
f) Any other information as per the need of course/faculty