Category L T P Credit
35321A13 BIOMATERIALS
EC-SE 3 0 0 3
PREAMBLE
A biomaterial is any substance that has been engineered to interact with biological systems for a medical purpose. These
materials are synthesized in the laboratory using a variety of chemical approaches utilizing metallic components, polymers,
ceramics or composite materials. It can be used every day in orthopedic application, dental applications, and surgery. The
primary objective of this course is to impart the knowledge on biomaterials needed to solve challenges in the biomedical
engineering.
PRERQUISITE : NIL
COURSE OBJECTIVES
1 To understand the properties of material for medical use.
2 To illustrate the applications of materials used in soft and hard tissue replacements.
3 To categorize classes of materials suitable for implant applications.
4 To outline the host response to the biomaterial and degradation of implant materials.
5 To the testing of material for medical application.
COURSE OUTCOMES
On the successful completion of the course, students will be able to
CO1. Describe the properties of material and different classes of biomaterials. Understand
CO2. Illustrate the various soft tissue replacement and orthopedic implants in hard tissue Apply
replacements.
CO3. Illustrate the types, properties, manufacturing methods and applications of various Analyze
biomaterials.
CO4. Analyze the mechanism of host-tissue interaction and failure of materials. Analyze
CO5. Analyze the protocol for the evaluations of Biomaterials. Analyze
MAPPING WITH PROGRAMME OUTCOMES AND PROGRAMME SPECIFIC OUTCOMES
COS PO1 PO2 PO3 PO4 PO5 PO6 PO7 PO8 PO9 PO10 PO11 PO12 PSO1 PSO2 PSO3
CO1 L -- -- -- -- -- -- -- M -- -- M -- M M
CO2 M M M -- - -- -- -- S -- -- S -- M M
CO3 S S -- -- -- L -- -- S -- -- S S S M
CO4 S S -- -- -- M -- -- S -- -- S S S S
CO5 S S M -- -- M -- -- S -- -- S S S S
S- Strong; M-Medium; L-Low
SYLLABUS
STRUCTURE AND PROPERTIES OF BIOMATERIALS: Biomaterials – Definition, Classification of biomaterials,
Structure of Crystalline and Amorphous solids, Properties of Biomaterials – Mechanical, Thermal, Phase diagrams, Surface,
Electrical, Optical, X-ray absorption, Acoustic, Ultrasonic, Density, Porosity and Diffusion properties. Biopolymers:
Collagen and Elastin. Technologies of biomaterials processing, Surface modification of materials, Surface Coatings Methods.
METALS AND CERAMICS: Metals -Stainless steel, Cobalt-Chromium alloy, Titanium alloys. Dental materials, NiTi
Shape-Memory Alloys, Other Clinically Applied Metallic Materials. Ceramics - Alumina, Zirconia, Hydroxyapatites. Dental
ceramics. Bioactive Glasses, Biodegradable Ceramics.
POLYMERIC BIOMATERIALS AND COMPOSITES: Structure, Classification and Synthesis of polymers,
Polyethylene, Polypropylene, Acrylate Polymer, Fluorocarbon polymers, Silicones, PETE, Polyurethane, Hydrogels,
Biodegradation of Polymers, Polyesters, Polyamides, Elastomeric Polyester, Composites as biomaterials.
SOFT AND HARD TISSUE APPLICATIONS: Sutures, Adhesives, Wound dressings, Maxillofacial and other Soft- tissue
augmentation, Heart valve implant, Cardiovascular Grafts and Stents. Orthopedic fixation devices: Internal fixation devices-
Wires, Pins, Screws, Fracture Plates and Intramedullary Devices. Joint replacement - Hip joint replacements, Knee joint
replacements, Ankle joint replacement, Upper Extremity joint replacements, Dental implants.
BODY RESPONSE, MATERIAL FAILUREANDBIOMATERIALS EVALUATION: Tissue Response to Injuries,
Body Response to Implants.Degradation of Implanted Materials - Deterioration of polymers, Biodegradation of biostable and
biodegradable polymers, Metal corrosion, Ceramic degradation, Device failure mode analysis.Biological Evaluations of
Biomaterials and Medical Products – Standards, Toxicological testing, Cytotoxicity testing, Evaluation in animals.
TEXT BOOKS:
1. Joon park, R.S. Lakes, “Biomaterials and introduction”, 3rd Edition, Springer Science Business Media LLC, 2007.
2. BD Ratner, AS Hoffmann, FJ Schoen, JE Lemmons, “An introduction to Materials in Medicine”, 3rd Edition,
Academic Press,2013.
3. Qizhi Chen, George Thouas, “Biomaterials-A Basic Introduction” CRC Press, Taylor & Francis Group, 2015.
REFERENCES:
1. Sujata V. Bhatt, “Biomaterials”, Second Edition, Narosa Publishing House,2005.
2. Joseph D. Bronzino, “The Biomedical Engineering Hand Book”, Second Edition, CRC Press LLC,2000.
COURSE DESIGNERS
S.No. Name of the Faculty Designation Department Mail ID
1 Mr.K.Natarajan Associate Professor BME natarajank@vmkvec.edu.in
2 Mr.V.Prabhakaran Assistant Professor (Gr-II) BME prabhakaran.bme@avit.ac.in
