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Organic 2 Lab 2

The document outlines the assay test procedure for Chlorpheniramine Maleate tablets, detailing the chemical properties and steps for conducting the test. It includes objectives, introduction to the compound, and specific steps for preparing and titrating the solution. The report section indicates that calculations for molarity and percentage purity are to be completed based on the results of the assay test.

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Noor Farhan
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29 views7 pages

Organic 2 Lab 2

The document outlines the assay test procedure for Chlorpheniramine Maleate tablets, detailing the chemical properties and steps for conducting the test. It includes objectives, introduction to the compound, and specific steps for preparing and titrating the solution. The report section indicates that calculations for molarity and percentage purity are to be completed based on the results of the assay test.

Uploaded by

Noor Farhan
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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ASSAY TEST

OF
CHLORPHENIRAMINE
MALEATE
Shameran J. Salih
shameran.salih@tiu.edu.iq
Organic Chemistry II (PHAR 215)
Spring Semester
Week Two
12/2/2024
Outline
Chlorpheniramine Maleate
Assay Test
Calculation
Objectives
◦ Learn how to conduct an assay test for Chlorpheniramine Maleate tablets.
Introduction
Chlorpheniramine maleate chemically known as 3-(4-chlorophenyl) N, N- Dimethyl-
3-(2-pyridyl) propylamine hydrogen maleate is an anti-histamine H1 receptor
antagonist.

• Chlorpheniramine maleate appears as odorless white crystalline solid or white


powder with a bitter taste.

Boiling point: 142 °C


Melting point: 130-135 °C
Chemical formula: C20H23ClN2O4
Solubility: Soluble in water (250 mg/mL) and ethanol (100 mg/mL).
M. Wt. 274.792 g/mol
Assay Test
1. Twenty tablets were weighed and grind into a fine powder.
2. An amount of powder equivalent to 200mg of chlorpheniramine maleate was
weighed accurately into 100ml standard flask.
3. 70ml of neutral alcohol was added and shaken for about 20 min.
4. Then, the volume was made up to mark with neutral alcohol, mixed well and filtered.
5. The first 10 ml portion of the filtrate was discarded.
6. An aliquot of the drug solution of chlorpheniramine maleate was measured
accurately and transferred into a clean 100 ml conical flask and the total volume was
brought to 10 ml with neutral alcohol.
7. Then 2 drops of 0.5% phenolphthalein indicator was added
8. The solution was titrated with standard 0.01M Sodium hydroxide solution until a
permanent pink color was obtained.
Calculation and Lab Report

Report
• The molarity of 0.01M Sodium hydroxide=
• The percentage purity of given Chlorpheniramine maleate tablet was found to be=

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