EARLY INFANTILE AUTISM
 INTRODUCTION
   Autism is a complex developmental disability that typically occurs during the first three
   years of life and is the result of a neurological disorder that affects the normal functioning
   of the brain, impacting development in the areas of social interaction and communication
   skills.
 DEFINITION
   Autism is a disorder of neural development that is characterized by impaired social
   interaction and communication, and by restricted and repetitive behavior.
 INCIDENCE
   According to World Health Organization (WHO), around 1 in 100 children have autism
   spectrum disorder (ASD). However, the prevalence of ASD in children varies by country
   and age group: A 2021 study in India found that around 1 in 68 children have ASD, with
   a higher prevalence in rural areas than in urban and tribal areas. The study also found that
   boys are more likely to be affected than girls with a ratio of 3:1.
 CAUSES
1. GENETIC FACTORS: Heredity
2. BIOCHEMICAL FACTORS: Alteration in the level of serotonin and growth hormone
   has been associated with autistic disorders.
3. DEVELOPMENTAL FACTORS: Autism appears to result from developmental factors
   that affect many or all functional brain systems and to disturb the timing of brain
   development more than the final product.
4. MIRROR NEURON SYSTEM (MNS) THEORY: The MNS theory of autism
   hypothesizes that distortion in the development of the MNS interferes with imitation and
   leads to autism’s core features of social impairment and communication difficulties.
5. UNDER CONNECTIVITY THEORY: It hypothesizes that autism is marked by under
   functioning high-level neural connections and synchronization along with an excess of
   low-level processes.
6. SYNAPTIC DYSFUNCTION: It may lead to autism by disrupting some synaptic
   pathways, such as those involved with cell adhesion
7. PERINATAL FACTORS: Maternal bleeding during gestation, use of medications during
   pregnancy
8. PARENTAL FACTORS: Parental rejection, faulty communication pattern, broken
   homes, parental stress etc.
9. ENVIRONMENTAL FACTORS:
a) Certain foods
b) Infectious diseases
c) Phenols used in plastic products
d) Pesticides
e) Alcohol
f) Smoking etc.
 CLINICAL MANIFESTATION
 SOCIAL DEVELOPMENT:
-   Social impairment
-   Lack of intuition about others
-   Smile and look at others less often
-   Less eye contact
-   Poor social understanding
-   Aggression and violence
-   Destruction of property
 COMMUNICATION:
-   Lack of natural speech
-   Delayed onset of babbling
-   Unusual gestures
-   Diminished responsiveness
-   Poor words, and word combinations
-   Echolalia
 REPETITIVE BEHAVIOR:
a) Stereotypy is repetitive movement, such as hand flapping, making sounds or head
   rolling
b) Compulsive behavior is intended and appears to follow rules, such as arranging objects
   in stacks or lines.
c) Sameness is resistance to change; for example, insisting that the furniture not be moved
   or refusing to be interrupted.
d) Ritualistic behavior involves an unvarying pattern of daily activities, such as an
   unchanging menu or a dressing ritual.
e) Restricted behavior is limited in focus, interest, or activity, such as preoccupation with a
   single television program, toy, or game.
f) Self-injury includes movements that injure or can injure the person, such as eye poking,
   skin picking, hand biting, and head banging.
 MANAGEMENT
1. Drug therapy such as Lithium, Resperidone etc.
2. Behavior therapy such as contingency management, positive reinforcement, self-care
   skills, role modeling early in life can help children acquire self-care, social, and job skills.
3. Psychotherapy such as supportive psychotherapy, counselling
4. Structured teaching:- Special school education including vocational training and
   residential treatment.
5. Cognitive therapy
6. Social skills therapy
7. Speech & language therapy
8. Applied behavior analysis (ABA):- Intensive ABA treatment has demonstrated
   effectiveness in enhancing global functioning in preschool children and is well-
   established for improving intellectual performance of young children.
9. Teacher training development programme to improve in skills of handling autistic
   children.
 CONCLUSION
  Autism affects millions of people, but the exact cause is still unknown. Autism is believed
  to be a genetic disorder and is caused by environmental factors. Autism affects an
  individual’s developmental learning and behavior and education is key when finding the
  treatment options which works best for each individual. Early diagnosis and treatment are
  the ways in which an individual with autism could receive the help that is needed.
                                     BIBLIOGRAPHY
   Datta Parul, A Textbook of Pediatric Nursing, Jaypee Publication, Fourth
                Edition, Page no: 584
   Gupta Ghai O.P , Ghai Piyush V.K., Essential Pediatrics, 6th Edition
           CBS Publishers and Distributors, Page No: 1001-1002
 Kurian Somya, A Textbook of Pediatric Nursing , EMMESS Publication
                Second Edition, Page no.: 448
   Sharma Rimple, Essentials Of Pediatric Nursing, Jaypee Publication,
           Third Edition, Page no: 530
   Yadav Manoj, A Textbook of Child Health Nursing, S. Vikas &
           Company (Medical Publishers), Revised Edition 2014, Page no.: 774
    ONLINE REFERENCES
    https://www.slideshare.net/slideshow/infantile-autism-seminarfinalpptx/254993648
    https://www.slideshare.net/kavindyamj16/childhood-autism-59459949
    ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)
 INTRODUCTION
    Attention deficit hyperactivity disorder (ADHD) also known as hyperkinetic disorder is
    the most common childhood disorder affecting school- aged children. Affected children
    commonly experience:
    - Academic underachievement
    - Problems with interpersonal relationships with family members and peers
    - Low self- esteem
    ADHD often co-occurs with other emotional, behavioral, language and learning disorders
 DEFINITION
    Attention – deficit hyperactive disorder is a childhood disorder characterized by persistent
    pattern of inattention and hyperactive and impulsive behavior.
 INCIDENCE
   About 5% of children and about 2.5% of adults have ADHD
   Primary school children in India- 11.32%
   More prevalent in boys
 RISK FACTORS
   Genetics: siblings with ADHD, identical twins have greater chances to develop ADHD
   Neurotransmitters: low levels of dopamine (causes hyperactivity and impulsivity) and
    nor epinephrine (causes inattention)
   Perinatal factors:
    a.   Maternal smoking and alcohol use during pregnancy
    b.   Pre-natal or post-natal exposure to lead
    c.   Birth complications
    d.   Premature birth
    •    Psycho-social factors:
    a.   Disorganized family pattern
    b.   Maternal mental disorder
    c.   Alcoholism in parents
    d.   Growing up in institutions ( foster homes)
 TYPES
   Inattentive type: symptoms of inattention
   Hyperactive/ impulsive type: symptoms of hyperactive and impulsive behavior
   Combined type: both inattention and hyperactivity
 CLINICAL FEATURES
   Poor attention span and distractibility:
    a. Inability to complete the task from start to finish
    b. Easily distracted
    c. Can’t sustain attention
    d. Careless mistakes
    e. Lack of details in work
    f. Have trouble organizing tasks
    g. Loses belongings frequently
    h. Difficulty following instructions
 Hyperactivity and impulsivity:
  a. Physical and/ or verbal over activity
  b. Appear to be in constant motion and “ on the go” as if driven by a motor
  c. Difficulty keeping their body still
  d. Restless behavior
  e. Talks excessively, interrupt others, not letting others talk
  f. Can’t remain seated at school or workplace
  g. Has difficulty waiting his or her turn or while waiting in line
 CRITERIA FOR ADD OR ADHD DIAGNOSIS
   Early onset: symptoms must have been present before age 7
   Duration: a combination of symptoms must have been present for atleast 6 months
   Settings: the symptoms must be present in 2 or more settings, such as home , school etc.
   Impact: the symptoms must have a negative impact on the individuals school, family
    and/ or social life
   Developmental level: the symptoms are not due to the child’s normal development level
   Alternative explanation: the symptoms are not caused by another physical, mental or
    emotional disorder
 MANAGEMENT
     Medications
    a. Stimulants to reduce hyperactivity and impulsivity and increase attention
        (methylphenidate and amphetamines)
    b. Non-stimulant medications: atomoxetine and bupropion
     Behavior therapy
      teaching the child time management and
      organization of skills.
      e.g. following structured routine
     Special education
     Social skills training
    Effective parenting
a.   Make clear schedules
b.   Maintain routines
c.   Make sure instructions are understood
d.   Focus on child when talking to him/ her, avoid multitasking
e.   Children with ADHD require more supervision than their peers
f.   Maintain communication with the child’s teacher
g.   Model calm behavior
h.   Focus on effort and reward good behavior
 CONCLUSION
  ADHD is the most common neurobehavioral disorder of childhood, among the most
  prevalent chronic health conditions affecting school- aged children and the most
  extensively studied mental disorder of childhood.
                                     BIBLIOGRAPHY
   Datta Parul, A Textbook of Pediatric Nursing, Jaypee Publication, Fourth
                Edition, Page no: 584
   Gupta Ghai O.P , Ghai Piyush V.K., Essential Pediatrics, 6th Edition
           CBS Publishers and Distributors, Page No: 1001-1002
 Kurian Somya, A Textbook of Pediatric Nursing , EMMESS Publication
                Second Edition, Page no.: 448
   Sharma Rimple, Essentials Of Pediatric Nursing, Jaypee Publication,
           Third Edition, Page no: 530
   Yadav Manoj, A Textbook of Child Health Nursing, S. Vikas &
           Company (Medical Publishers), Revised Edition 2014, Page no.: 774
    ONLINE REFERENCES
    https://www.slideshare.net/mamtabisht10/attention-deficit-hyperactivity-disorder-adhd-
    235266029
    https://www.slideshare.net/slideshow/attention-deficit-hyperactivity-disorder-
    240434312/240434312
                         CHILDHOOD SCHIZOPHRENIA
 DEFINITION
    Childhood schizophrenia is a severe brain disorder in which children interpret reality
    abnormally. Schizophrenia involves a range of problems with thinking (cognitive),
    behavior or emotions.
 ETIOLOGY
   Unknown
   Brain disorders
   Genetics and environment
   Problems with neurotransmitters
   Difference in brain structure
 RISK FACTORS
   Family history of schizophrenia
   Exposure to viruses, toxins or malnutrition while in the womb
   Abnormal activation of the immune system
   Older age of the father
   Taking psychoactive drugs during teen years
   ONSET
   Symptoms start in the late teens to the mid- 30s
   Early- onset schizophrenia occurs in children younger than age 17
   Very early- onset schizophrenia in children younger than age 13
 CLINICAL FEATURES
 Early sign and symptoms:
  - Language delays
  - Late or unusual crawling
  - Late walking
  - Other abnormal motor behaviors
   Symptoms in teenagers:
    - Withdrawal from friends and family
    - A drop in performance at school
    - Trouble sleeping
    - Irritability or depressed mood
    - Lack of motivation
    - Strange behavior
 Later sign and symptoms:
  - Hallucinations
  - Delusions
  - Disorganized thinking (speech)
  - Disorganized or abnormal motor behavior
  - Negative symptoms
 DIAGNOSTIC MEASURES
   Child’s medical and psychiatric history
   Conduct a physical examination
   Medical and psychological screenings
   Review school records
   Blood tests
   Magnetic resonance imaging (MRI) or computed tomography (CT)
   Electroencephalogram (EEG)
 PSYCHOLOGICAL EVALUATION
   Observe appearance and demeanor
   Asking about thoughts, feelings and behavior patterns
   Talking to child about any thoughts of self- harm or harming others
   Evaluate the ability to think and function at an age- appropriate level
   Assessing mood, anxiety and possible psychotic symptoms
 DIAGNOSTIC CRITERIA
   Hallucinations
   Delusions
   Disorganized speech
   Disorganized behavior
   Catatonic behavior which can range from a coma- like daze to bizarre, hyperactive
    behavior
   Negative symptoms which relate to lack of or reduced ability to function normally
 MANAGEMENT
   Medications
   Individual and family therapy
   Social and academic skills training
   Hospitalization
   Lifestyle and home remedies
 CONCLUSION
  Schizophrenia is a very serious illness, often people don’t realize how
  serious this illness is. Schizophrenia is a relatively common chronic mental
  illness which results in substantial disability and has a 10% risk of suicide.
  Schizophrenia affects men and women equally, but it is usually diagnosed
  earlier in men.
                                     BIBLIOGRAPHY
   Datta Parul, A Textbook of Pediatric Nursing, Jaypee Publication, Fourth
                Edition, Page no: 584
   Gupta Ghai O.P , Ghai Piyush V.K., Essential Pediatrics, 6th Edition
           CBS Publishers and Distributors, Page No: 1001-1002
 Kurian Somya, A Textbook of Pediatric Nursing , EMMESS Publication
                Second Edition, Page no.: 448
   Sharma Rimple, Essentials Of Pediatric Nursing, Jaypee Publication,
           Third Edition, Page no: 530
   Yadav Manoj, A Textbook of Child Health Nursing, S. Vikas &
           Company (Medical Publishers), Revised Edition 2014, Page no.: 774
    ONLINE REFRENCES
    https://www.slideshare.net/slideshow/child-schizophrenia-and-
    depression/33353221
    https://www.slideshare.net/slideshoe/pediatric-schizophrenia-childhood-
    onset-schizophrenia/214801588
                            CHILDHOOD DEPRESSION
 DEFINITION
  Being unable to enjoy activities that they once enjoyed, complaining about physical
  ailments or may seem bored and have problems concentrating among other symptoms.
 INCIDENCE
 Each year depression affects 17 million people of all age groups, races, and economic
  backgrounds.
 1 in every 33 children may have depression
 In teens, that number may be as high as 1 in 8
   CAUSES
   Lowered levels of neurotransmitters in the brain
   Genetics
   Significant life events
   Stress
   Chronic illness
   TYPES
   Major depression
   Dysthymia
   Bipolar disorder
   CLINICAL FEATURES
   Changes in appetite
   Changes in sleep
   Continuous feeling of sadness or hopelessness
   Difficulty concentrating
   Fatigue and low energy
   Feelings of worthlessness or guilt
   Impaired thinking or concentration
   Increased sensitivity to rejection
   Irritability or anger
   Social withdrawl
   DIAGNOSTIC MEASURES
   History
   Mental status examination
   Laboratory tests
   X- ray, scan or other imaging study
 MANAGEMENT
   Addressing any medical conditions
   Supportive therapy
   Psychotherapy
   Interpersonal therapy
   Cognitive behavioral therapy
   Complementary therapies
   Medications
 CONCLUSION
  Childhood depression is a chronic and disabling disorder. It needs expertise to diagnose
  childhood depression due to myriad of symptoms. It should be identified and treated
  because it has got a significant adverse affect on a youth’s emotional, social and cognitive
  development.
                                     BIBLIOGRAPHY
   Datta Parul, A Textbook of Pediatric Nursing, Jaypee Publication, Fourth
                Edition, Page no: 584
   Gupta Ghai O.P , Ghai Piyush V.K., Essential Pediatrics, 6th Edition
           CBS Publishers and Distributors, Page No: 1001-1002
 Kurian Somya, A Textbook of Pediatric Nursing , EMMESS Publication
                Second Edition, Page no.: 448
   Sharma Rimple, Essentials Of Pediatric Nursing, Jaypee Publication,
           Third Edition, Page no: 530
   Yadav Manoj, A Textbook of Child Health Nursing, S. Vikas &
           Company (Medical Publishers), Revised Edition 2014, Page no.: 774
    ONLINE REFRENCES
    https://www.slideshare.net/slideshow/child-schizophrenia-and-
    depression/33353221
    https://www.slideshare.net/slideshow/childhood-depression-247200687-247200687